Antithrombotic and anticomplementary properties of a very low molecular mass dermatan sulfate

Alberto, María Fabiana; Romero, Diego Giaquinta; Lazzari, M.A.; Calabrese, Graciela Cristina

doi:10.1016/j.thromres.2007.09.001

Cited by 10 publications

(2 citation statements)

References 38 publications

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“…The early studies of heparin structure and function concentrated on the interactions responsible for its inhibition of blood coagulation, but the observation that heparin-containing tissues are in direct contact with the external environment suggests it may also play a role in host defense. Heparin binds a number of growth factors [67], as well as extracellular matrix proteins [68,69,70,71], proteins involved in lipid metabolism (such as apolipoprotein) [72,73,74], and acute phase [75,76,77,78,79,80,81] and complement factors [82,83,84,85,86,87]. There is also accumulating evidence that it interferes with the adhesion of leukocytes to the endothelium, a mechanism that plays a central role in the inflammatory response.…”

Section: Multiple Functions Of Heparinmentioning

confidence: 99%

Alzheimer's Disease: Another Target for Heparin Therapy

Bergamaschini

Rossi

Vergani

et al. 2009

The Scientific World JOURNAL

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Alzheimer's disease (AD) is the leading cause of dementia and cognitive decline in the elderly. Brain tissue changes indicate that the two main proteins involved in AD are amyloid-β(A-β), which is associated with the formation of senile amyloid plaques, and tau, which is associated with the formation of neurofibrillary tangles. Although a central role for A-β in the pathogenesis of AD is indisputable, considerable evidence indicates that A-β production is not the sole culprit in AD pathology. AD is also accompanied by an inflammatory response that contributes to irreversible changes in neuronal viability and brain function, and accumulating evidence supports the pivotal role of complement and contact systems in its pathogenesis and progression. The complexity of AD pathology provides numerous potential targets for therapeutic interventions. Compounds that interact directly with A-β protein or interfere with its production and/or aggregation can reduce the inflammatory and neurotoxic effects of A-β, and heparin, a glycosaminoglycan mixture currently used in the prophylaxis and treatment of thrombosis, might be a candidate, as recent research has been extended to consider its nonanticoagulant properties, including its modulation of various proteases and anti-inflammatory activity.

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Section: Multiple Functions Of Heparinmentioning

confidence: 99%

Alzheimer's Disease: Another Target for Heparin Therapy

Bergamaschini

Rossi

Vergani

et al. 2009

The Scientific World JOURNAL

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“…Sulphated glycosaminoglycans [41] are well known to inhibit the complement system in vitro . We investigated the role of the sulphate groups on the EPS glycan structure in regard to their capacity to inhibit the complement system, particularly via the classical pathway.…”

Section: Resultsmentioning

confidence: 99%

Exopolysaccharides Isolated from Hydrothermal Vent Bacteria Can Modulate the Complement System

et al. 2014

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The complement system is involved in the defence against bacterial infection, or in the elimination of tumour cells. However, disturbances in this system contributes to the pathogenesis of various inflammatory diseases. The efficiency of therapeutic anti-tumour antibodies is enhanced when the complement system is stimulated. In contrast, cancer cells are able to inhibit the complement system and thus proliferate. Some marine molecules are currently being developed as new drugs for use in humans. Among them, known exopolyssacharides (EPSs) generally originate from fungi, but few studies have been performed on bacterial EPSs and even fewer on EPSs extracted from deep-sea hydrothermal vent microbes. For use in humans, these high molecular weight EPSs must be depolymerised. Furthermore, the over-sulphation of EPSs can modify their biological activity. The aim of this study was to investigate the immunodulation of the complement system by either native or over-sulphated low molecular weight EPSs isolated from vent bacteria in order to find pro or anti-activators of complement.

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Chondroitin sulfate: extraction, purification, microbial and chemical synthesis

Shi

Meng

Lǐ

et al. 2014

J of Chemical Tech & Biotech

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Chondroitin sulfate, a type of acid mucopolysaccharide possessing a variety of bioactivities, has attracted tremendous interest due to its use in the relief of joint diseases. It has been widely applied in different fields, such as medicine, biotechnology, pharmacy, textiles, food and cosmetics. This mini‐review focuses on the main methods of its extraction and purification, and recent advances in bio‐syntheses and chemical synthesis of such molecules. In addition, further studies in these aspects are proposed based on current research. © 2014 Society of Chemical Industry

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Antithrombotic and anticomplementary properties of a very low molecular mass dermatan sulfate

Cited by 10 publications

References 38 publications

Alzheimer's Disease: Another Target for Heparin Therapy

Alzheimer's Disease: Another Target for Heparin Therapy

Exopolysaccharides Isolated from Hydrothermal Vent Bacteria Can Modulate the Complement System

Chondroitin sulfate: extraction, purification, microbial and chemical synthesis

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