Antitproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro

Kandaswami, Chithan; Perkins, Eddie; Soloniuk, Donald S.; Drzewiecki, G.; Middleton, Elliott

doi:10.1016/0304-3835(91)90089-z

Cited by 193 publications

(111 citation statements)

References 20 publications

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“…Unfortunately, the precise cause of cancer is still largely unknown. In the past decades, an increasing evidences have demonstrated that diet rich in vegetables and fruit is associated with a decrease in the incidence of various human chronic diseases such as cancers, obesity and diabetes, cardiovascular diseases, dementia and neurodegenerative disorders [2,82], and the studies concerning Citrus flavonoids and their roles in the prevention and treatment of human cancers have attracted more and more attentions in scientific world [83,84]. A summary of the possible mechanism of action by which Citrus flavonoids play their roles is given in Figure. 3.…”

Section: Citrus Flavonoids and Human Cancer Prevention And Treatmentmentioning

confidence: 99%

<i>Citrus</i> Flavonoids and Human Cancers

Ke¹,

Pan²,

Xu³

et al. 2015

JFNR

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Nowadays cancers pose a great threat to the health of human beings. Based on studies on the flavonoids and other bioactive compounds of Citrus fruits in current literature, it was widely suggested that the consumption of Citrus fruits is beneficial to the prevention and treatment of human chronic diseases including cancers. In the past decades, the study concerning Citrus flavonoids has covered various areas including the type, content and distribution of flavonoids in fruits; their variation between wild and cultivated genotypes; their antioxidant, antiinflammation, anti-aging, antimicrobial and anticarcinogenic activities. To enlighten future Citrus germplasm study, this review introduces briefly the functions of main types of Citrus flavonoids, including antioxidant, antiinflammation and anti-aging activities, and their relationships to human cancers. Most importantly, the mechanisms of action by which Citrus flavonoids play their roles in human cancer prevention and treatment were summarized.

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Section: Citrus Flavonoids and Human Cancer Prevention And Treatmentmentioning

confidence: 99%

<i>Citrus</i> Flavonoids and Human Cancers

Ke¹,

Pan²,

Xu³

et al. 2015

JFNR

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“…[7][8][9][10][11] Polymethoxylated flavones are also of interest for their various pharmacological potentials, the most important of which are antitumor, anti-inflammatory, antimutagenic, and antiallergic properties. [12][13][14][15][16][17] Rutin, a flavonol glycoside commonly found in citrus fruit peels, has been shown to have significant anti-inflammatory properties. 18) In general, the contents and distributions of flavonoids in different Citrus species are highly variable and depend on genetic and environmental factors.…”

mentioning

confidence: 99%

Correlation between Flavonoid Content and the NO Production Inhibitory Activity of Peel Extracts from Various Citrus Fruits

Choi

et al. 2007

Biological & Pharmaceutical Bulletin

168

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“…Research with tangeretin and nobiletin has shown that these chemicals can inhibit, in vitro, the proliferation of cancer cells (42)(43)(44) including a human squamous cell carcinoma (HTB43), a gliosarcoma (9L) and two melanoma cell lines (B16F10 and SK-MEL-1). Tangeretin was also found to inhibit the microsome-catalyzed binding of benzo [a]pyrene to DNA (45) and the binding of aflatoxin Bl to DNA (46).…”

Section: Beneficial Roles Of Citrus Flavonoids: From Cell Assays To Amentioning

confidence: 99%

Potential Health Benefits of Citrus: An Overview

Patil

Brodbelt

Miller

et al. 2006

ACS Symposium Series

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Recent studies have documented a number of health benefits associated with the consumption of citrus, largely due to the natural phytochemicals found in these fruits, such as flavonoids, limonoids, furocoumarins, and pectins. Interest in the chemopreventive properties of phytochemicals has led to more detailed studies to determine the mechanisms of action of these compounds in animal models and humans, to optimize the levels of the phytochemicals in citrus based on agricultural and processing factors, and to develop better analytical methods for identifying and quantifying phytochemicals in complex mixtures. This chapter provides an overview of the many aspects of citrus and its health benefits that will be described in more detail in chapters throughout this book.

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Antitproliferative effects of citrus flavonoids on a human squamous cell carcinoma in vitro

Cited by 193 publications

References 20 publications

<i>Citrus</i> Flavonoids and Human Cancers

<i>Citrus</i> Flavonoids and Human Cancers

Correlation between Flavonoid Content and the NO Production Inhibitory Activity of Peel Extracts from Various Citrus Fruits

Potential Health Benefits of Citrus: An Overview

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