Antitubercular Drug induced Hepatitis: An Adverse Drug Reaction

Abstract

Antitubercular drugs are the first line agents for the management of tuberculosis. Drug induced hepatotoxicity is an unexceptional adverse effect mostly caused by antitubercular drugs leading to cessation of therapy. The keystone for the treatment of tuberculosis is a 6-month regimen consisting of drugs such as Isoniazid, rifampicin, pyrazinamide and ethambutol. Although Antitubercular drugs are only option for the treatment for pulmonary TB, Hepatotoxicity is one of the most detrimental adverse events leading to interruption of treatment thereby causing drug resistance. In this case the patient was recently diagnosed with pulmonary tuberculosis one month ago, consequently developed hepatotoxicity due to use of anti-tuberculosis drugs. Naranjo Adverse Drug Reaction Probability Scale was used to assess the adverse Drug effect and the score was found to be probable thereby indicating that Anti TB drugs cause hepatitis.

Isoniazid-induced hepatic injury: a case report and its mechanism of liver injury

“…Although CYP2E1 c1/c1 was present in both the DILI and non-DILI groups, the genotypes C/D or C/C were three times more likely to result in anti-TB DILI. The same study showed that the risk of DILI went up when the NAT2 gene polymorphism was combined with the CYP2E1 C/D or C/C genotype [33,38,39].…”

investigation of the physiology effects of amikacin and the protective role of L- carnittine and vitamin C in adult male rats

“…In rare cases, amikacin can also cause hepatitis or hepatitis. Blood tests that monitor levels of liver enzymes and bilirubin the red stains that form when red blood cells are removed diagnose liver disease [24].…”

Hepatoprotective effect of Hydro-alcohol extract of Mimusops elengi root against antitubercular drug-induced hepatotoxicity in rats

“…According to World Health Organization (WHO), tuberculosis has been declared a global health emergency, with almost onethird of the world's population estimated to be infected. Directly observed treatment, short-course (DOTS) is the mainstay of tuberculosis treatment, according to the RNTCP (Begum, Parveen, Sultana, Fatima, & Fareedullah, 2020). The liver is the largest solid organ in the body as well as the largest gland.…”