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Antitubercular drugs are the first line agents for the management of tuberculosis. Drug induced hepatotoxicity is an unexceptional adverse effect mostly caused by antitubercular drugs leading to cessation of therapy. The keystone for the treatment of tuberculosis is a 6-month regimen consisting of drugs such as Isoniazid, rifampicin, pyrazinamide and ethambutol. Although Antitubercular drugs are only option for the treatment for pulmonary TB, Hepatotoxicity is one of the most detrimental adverse events leading to interruption of treatment thereby causing drug resistance. In this case the patient was recently diagnosed with pulmonary tuberculosis one month ago, consequently developed hepatotoxicity due to use of anti-tuberculosis drugs. Naranjo Adverse Drug Reaction Probability Scale was used to assess the adverse Drug effect and the score was found to be probable thereby indicating that Anti TB drugs cause hepatitis.

Objective: The objective of the study was to compare the effects of nebulized 3% hypertonic saline and nebulized levosalbutamol in the management of bronchiolitis. Methods: Seventy children of age 1–24 months admitted into the hospital with the diagnosis of bronchiolitis. Participants were divided into two groups of 35 each. Group A was given nebulized 3% hypertonic saline and Group B was given nebulized levosalbutamol. Modified respiratory distress assessment instrument (RDAI) is used at admission, at 48 h after admission, and at the time of discharge to identify the reduction in scores between two groups. Results: The mean age of patients in the study population was 10.1±6.4 months. The mean birth weight of patients in Group A and Group B was 3.00±0.61 and 3.12±0.75. The percentage of male patients was 57.1% and the percentage of female patients was 42.8%. The modified RDAI score in Group A and Group B at admission, 48 h of admission, and at the time of discharge was 4.34±0.87, 2.4±1.03, and 0.67±0.05 (p=0.04) and 4.11±0.58, 3.60±1.00, and 2.51±0.96 (p=0.12). The hospital stay was observed to be lowered in Group A (3.77±0.88) compared to Group B (5.43±0.92; p=0.04). Conclusion: From the findings of our study, we conclude that nebulized 3% hypertonic saline, as it acts by hindering the pathophysiologic mechanism of bronchiolitis, is more effective in reducing the clinical severity score and length of hospital stay. Further 3% hypertonic saline also have the additional benefit of decreasing the economic burden of disease as it is safe, inexpensive, reduces the inpatient hospital charges by reducing the length of stay.