Antitumor action of glycopeptides from the cell wall of Lactobacillus bulgaricus

Bogdanov, I.G.; Velichkov, V. T.; Gurevich, A. I.; Далев, П.; Kolosov, M. N.; Mal'kova, V. P.; Sorokina, I. B.; Khristova, L. N.

doi:10.1007/bf00804826

Cited by 38 publications

(30 citation statements)

References 3 publications

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“…Figure 2 depicts the mapping of leu-lys-pro onto Hypo 1. Table 1 Chemical structures of the 20 training set molecules [7][8][9][10][11][12][13][14][15] leu-lys-pro (IC 50: 0.32 μmol·L −1 ) val-trp (IC 50: 1.7 μmol·L −1 ) ile-arg-pro (IC 50: 1.8 μmol·L −1 ) leu-ala-pro (IC 50: 2.3 μmol·L −1 )…”

Section: Pharmacophore Generation Using Ds Catalystmentioning

confidence: 99%

“…Based on the published literature, we collected 20 compounds as the training set (Table 1) to generate pharmacophore models for ACE inhibitory peptides [7][8][9][10][11][12][13][14][15] . The peptides were built using the DS 2.0 biopolymer and were minimized to the closest local minimum using the CHARMm force field implemented in the DS 2.0 program.…”

Section: Generation Of Pharmacophore Modelsmentioning

confidence: 99%

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Pharmacophore-based structure optimization of angiotensin converting enzyme inhibitory peptide

Wang

Shen

Feng

et al. 2008

Sci. China Ser. B-Chem.

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Chemical feature based pharmacophore models were generated for an angiotensin converting enzyme (ACE) inhibitory peptide using the Discovery Studio 2.0 pharmacophore modeling approach. The pharmacophore hypothesis selected has five features (one negative ionizable region, one hydrogen bond donor, one hydrogen bond acceptor and two hydrophobic functional groups). Additionally, ACE inhibitory hexapeptide previously obtained from silkworm pupae protein was optimized to target the ACE based on the selected pharmacophore. The results suggest that tri-peptide (thr-val-phe) may be structural determinant of ACE activity. Docking studies further provided confidence for the validity of the selected pharmacophore model to perform structure optimization of the ACE inhibitory peptide.angiotensin converting enzyme, inhibitory peptide, pharmacophore model, docking

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Section: Pharmacophore Generation Using Ds Catalystmentioning

confidence: 99%

Section: Generation Of Pharmacophore Modelsmentioning

confidence: 99%

Pharmacophore-based structure optimization of angiotensin converting enzyme inhibitory peptide

Wang

Shen

Feng

et al. 2008

Sci. China Ser. B-Chem.

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“…The number of cells was reduced by about 23-35% as measured by total cell count and total DNA content [55,56]. In another study, L. bulgaricus has been shown to possess po tent antitumor activity, which is mediated by three glycopeptides with in vitro activity against sarcoma-180 and solid Ehrlich ascites tumor cells [57], Further support for the antitumor effect of lactic acid bacteria comes from studies con ducted by Goldin and Gorbach [58. 59], Oral supplementation of the diet of humans and rats with viable L. acidophilus of human ori gin caused a significant decline in the fecal levels of bacterial P-glucuronidase, azoreduc tase and nitroreductase.…”

Section: Lactic Acid Bacteria and Carcinogensmentioning

confidence: 98%

Lactic Acid Bacteria in the Gut in Normal and Disordered States

Salminen¹,

Deighton

1992

Dig Dis

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The human gut flora is a complex and finely balanced ecosystem which plays an important protective role in humans. Although relatively stable, its composition may be altered in various disease states and by the administration of antimicrobial agents. Preparations containing viable lactic acid bacteria of human origin appear to have value in restoring normal microbial function and alleviating symptoms in some patients with gastrointestinal infection and other conditions.

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“…Therefore, the antimutagenic glycoproteins purified in this study were thought to have different features from the antitumor glycopeptide purified from L. delbrueckii subsp. bulgaricus cells (3).…”

Section: Figmentioning

confidence: 99%

“…A variety of lactic acid bacteria isolated from fermented milk products have been previously reported as displaying antitumor and anticarcinogenic activities in experimental mice (1,11,12) as well as antimutagenic activity on Salmonella enterica serovar Typhimurium (11,18). Three molecules possessing antitumor effects, glycopeptide, polysaccharide, and phosphopolysaccharide, were purified and characterized from lactic bacteria, but none of the antimutagenic substances has been purified thus far (3,16,17).…”

mentioning

confidence: 99%

Three Glycoproteins with Antimutagenic Activity Identified in Lactobacillus plantarum KLAB21

Rhee

Park

2001

Appl Environ Microbiol

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Antimutagenic substances were purified from a culture supernatant of Lactobacillus plantarum KLAB21 cells isolated from kimchi, a Korean traditional fermented vegetable, and their characteristics were investigated. The antimutagenic substances were separated into two fractions by DEAE-cellulose ion-exchange column chromatography, which were designated the R1 and R2 fractions. The R1 fraction was then divided into two fractions again by Sephadex G200 gel filtration chromatography, and the fractions were designated R1-1 and R1-2. All three fractions were further purified using a Sepharose CL-6B gel filtration column. All the purified fractions were successfully stained with fuchsin as well as Coomassie brilliant blue, suggesting that they are glycoproteins. The purified fractions were confirmed to possess antimutagenic activity against N-methyl-Nnitro-N-nitrosoguanidine on Salmonella enterica serovar Typhimurium TA100 cells. Their molecular masses were determined to be 16 (R1-1), 11 (R1-2), and 14 (R2) kDa on the Sepharose CL-6B column. Total sugar contents were 8.4% (R1-1), 7.3% (R1-2), and 9.4% (R2). The amino acid compositions of the fractions were different from each other; the major amino acids were glutamic acid (21.5%) and phenylalanine (17.1%) in the R1-1 fraction and glycine (41.3%) in the R1-2 fraction, but valine (31%) and phenylalanine (22.6%) were the major amino acids in the R2 fraction.

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Antitumor action of glycopeptides from the cell wall of Lactobacillus bulgaricus

Cited by 38 publications

References 3 publications

Pharmacophore-based structure optimization of angiotensin converting enzyme inhibitory peptide

Pharmacophore-based structure optimization of angiotensin converting enzyme inhibitory peptide

Lactic Acid Bacteria in the Gut in Normal and Disordered States

Three Glycoproteins with Antimutagenic Activity Identified in Lactobacillus plantarum KLAB21

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