Antitumor action of shiitake(Lentinus edodes) fruit bodies orally administered to mice.

Nanba, Hiroaki; Mori, Kanichi; Toyomasu, Tetsuro; Kuroda, Hisatora

doi:10.1248/cpb.35.2453

Cited by 46 publications

(24 citation statements)

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“…14 Since some of the actions exerted by this isolated polysaccharide have also been found in experiments using L. edodes fruiting bodies, 15,16 we suppose that the aqueous extract used in this study could have acted in a manner similar to that of lentinan, increasing blood stream monocytes and possibly granulocyte progenitors (CFU-GMs). In fact, although we do not know the chemical composition of L. edodes aqueous extract, it had been demonstrated that aqueous extracts of several mushrooms contain a high concentration of polysaccharides, which could be responsible for the bioactive effects.…”

Section: Discussionmentioning

confidence: 78%

Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting

Lima

Sugui

Petrício

et al. 2013

Journal of Medicinal Food

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This study was undertaken to understand how Lentinula edodes modulates in vivo mutagenesis induced by alkylating agents in bone marrow and peripheral blood as described in our previous article. Male Swiss mice were pretreated for 15 consecutive days with aqueous extracts prepared from L. edodes, after which, the number of circulating blood cells, normal erythroid bone marrow cell cycling, and phagocytosis of micronucleated reticulocyte (MNRET) and activation of spleen macrophages were assessed. The results indicate that the antimutagenicity seen in bone marrow and peripheral blood is exerted by distinct compounds with different actions. The antimutagenic effect in bone marrow is exerted by compounds subject to degradation at deep-freeze storage temperature of -20°C. On the other hand, compounds responsible for antimutagenicity in peripheral blood are not subject to degradation at -20°C. The results also indicate that the antimutagenic action in peripheral blood leading to the reduction of circulating MNRET occurs in the spleen primarily through a phagocytic activity due to higher macrophage numbers and probably not due to the enhanced activation state of individual cells.

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Section: Discussionmentioning

confidence: 78%

Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting

Lima

Sugui

Petrício

et al. 2013

Journal of Medicinal Food

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“…␤-1,3-glucan, there were also earlier reports that some mushroom ␤-1,3;1,6-glucans could mediate tumor regression when given orally (18,19). In more recent studies using human tumor xenografts, orally administered soluble barley ␤-1,3;1,4-glucan or i.v.…”

mentioning

confidence: 90%

Mechanism by Which Orally Administered β-1,3-Glucans Enhance the Tumoricidal Activity of Antitumor Monoclonal Antibodies in Murine Tumor Models

Hong

Yan

Baran

et al. 2004

The Journal of Immunology

436

399

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Antitumor mAb bind to tumors and activate complement, coating tumors with iC3b. Intravenously administered yeast β-1,3;1,6-glucan functions as an adjuvant for antitumor mAb by priming the inactivated C3b (iC3b) receptors (CR3; CD11b/CD18) of circulating granulocytes, enabling CR3 to trigger cytotoxicity of iC3b-coated tumors. Recent data indicated that barley β-1,3;1,4-glucan given orally similarly potentiated the activity of antitumor mAb, leading to enhanced tumor regression and survival. This investigation showed that orally administered yeast β-1,3;1,6-glucan functioned similarly to barley β-1,3;1,4-glucan with antitumor mAb. With both oral β-1,3-glucans, a requirement for iC3b on tumors and CR3 on granulocytes was confirmed by demonstrating therapeutic failures in mice deficient in C3 or CR3. Barley and yeast β-1,3-glucan were labeled with fluorescein to track their oral uptake and processing in vivo. Orally administered β-1,3-glucans were taken up by macrophages that transported them to spleen, lymph nodes, and bone marrow. Within the bone marrow, the macrophages degraded the large β-1,3-glucans into smaller soluble β-1,3-glucan fragments that were taken up by the CR3 of marginated granulocytes. These granulocytes with CR3-bound β-1,3-glucan-fluorescein were shown to kill iC3b-opsonized tumor cells following their recruitment to a site of complement activation resembling a tumor coated with mAb.

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“…It has been described as T-cell-oriented adjuvant in vivo [2], but is also potentiates NK cell activity [20,13,6] and several macrophage/monocyte functions (e. g. antibody-dependent cellular cytotoxicity, interleukin-1 and superoxide anion production, spreading, phagocytosis, and cytotoxicity) [1,5,7,8,13,14, 20]. In previous studies lentinan inhibited the lung colony for--marion of Lewis lung tumor [11,12], while it was ineffective against the highly metastatic LLT-HH line [1 t ].…”

Section: Introductionmentioning

confidence: 99%

Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells

Ladányi

Tı́már

Lapis

1993

Cancer Immunol Immunother

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We studied the effect of lentinan, a fungal polysaccharide immunomodulator, on mouse peritoneal macrophages. The i.p. treatment of mice with 10 mg/kg lentinan affected the number, plastic-adherence, and endogen peroxidase activity of peritoneal cells. The cytotoxicity of lentinan-stimulated peritoneal macrophages was determined against several murine and human metastatic tumor targets: Lewis lung carcinoma (LLT) and two human melanomas, and was found to be significantly higher than that of the macrophages from control animals. However, the highly metastatic variant of LLT (LLT-HH) was resistant to the cytolytic effect of resident and lentinan-activated macrophages as well, indicating that the stimulation for cytotoxicity depends not only on the functional activity of the effector but also on the sensitivity of the target.

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Antitumor action of shiitake(Lentinus edodes) fruit bodies orally administered to mice.

Cited by 46 publications

References 0 publications

Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting

Lentinula edodes (Shiitake) Modulates Chemically Induced Mutagenesis by Enhancing Pitting

Mechanism by Which Orally Administered β-1,3-Glucans Enhance the Tumoricidal Activity of Antitumor Monoclonal Antibodies in Murine Tumor Models

Effect of lentinan on macrophage cytotoxicity against metastatic tumor cells

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