2010
DOI: 10.1590/s1984-82502010000200005
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Antitumor activity of leaves of Himatanthus drasticus (Mart.) Plumel-Apocynaceae (janaguba) in the treatment of Sarcoma 180 tumor

Abstract: Himatanthus drasticus, also known as janaguba, is used popularly in Brazil's Northeastern region in the treatment of cancer. However, no scientific reports are available. The present study is the first investigation on the antitumor activity of crude methanolic extract from Himatanthus drasticus leaves against Sarcoma 180 tumor and on its side effects including acute oral toxicity. The OECD 423 methodology was used to study acute oral toxicity, and the STOCK methodology to assess antitumor activity. The crude … Show more

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Cited by 23 publications
(14 citation statements)
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“…There are studies of H. drasticus latex evaluating its antiulcerogenic, antitumor, analgesic, and antiinflammatory activities, which somehow justify their popular uses in the treatment of cancer, gastric disorders, rheumatism, and bruises. [ 1 11 12 13 14 15 16 17 18 ]…”
Section: Resultsmentioning
confidence: 99%
“…There are studies of H. drasticus latex evaluating its antiulcerogenic, antitumor, analgesic, and antiinflammatory activities, which somehow justify their popular uses in the treatment of cancer, gastric disorders, rheumatism, and bruises. [ 1 11 12 13 14 15 16 17 18 ]…”
Section: Resultsmentioning
confidence: 99%
“…Another study evaluated the acute toxicity of the extract from leaves of H. drasticus, with the animals showing signs of excitability, agitation and increased respiratory rate (dose = 2,000 mg/kg) [ 50 ]. Nevertheless, neither histopathological changes, nor other signs of toxicity were observed, suggesting that species of the genus Himatanthus have low acute toxicity.…”
Section: Resultsmentioning
confidence: 99%
“…, Sousa et al . ). The preliminary results of pharmacological studies of the leaves, bark, and latex of this species have validated its popular use as an analgesic and it's antitumor and immunostimulant properties (Colares et al .…”
Section: Methodsmentioning
confidence: 97%