Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180

Facchini, Jean Mary; Alves, Endi Pricila; Aguilera, Charlise; Gern, Regina Maria Miranda; Silveira, Marcia Luciane Lange; Wisbeck, Elisabeth; Furlan, Sandra Aparecida

doi:10.1016/j.ijbiomac.2014.04.033

Cited by 66 publications

(36 citation statements)

References 20 publications

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“…The protein-polysaccharide from P. ostreatus and P. sajor-caju inhibited the growth of a solid Sarcoma 180 tumor implanted in mice [71]. In addition, the hot water extracts of P. sajor-caju and P. pulmonarius inhibited HIV-1 reverse transcriptase activity [72]. Similar activity was also observed by Choi et al [73] with hot water and ethanol extracts from fruiting body of oyster mushroom that exerted positive effect on three human solid carcinomas, (A549) and two cervical carcinomas (SiHa and HeLa).…”

Section: Immunotherapy Of Mushroom Polysaccharides From Pleurotus Spementioning

confidence: 99%

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Oloke¹

2015

IJI

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Abstract:In the recent years, mushrooms are distinguished as important natural resources of immunotherapy which can be used as immunomodulating and immunostimulating in the management of some immunodeficiency diseases such as cancer, tumour, HIV, tuberculosis etc. Mushroom of the genus Pleurotus are good sources of several bioactive compounds which are able to augment or complement a desired immune response. Such bioactive compounds are polysaccharopeptides, polysaccharide-proteins, functional proteins (ubiquinone-9, nebrodeolysin, ubiquitin-like peptide and glycoprotein), glucans, proteoglycans and many others. Most of these bioactive compounds follow the immunomodulatory pathway mechanism of polysaccharide (β-glucan) from mushrooms by stimulating activities for both innate and adaptive immune systems. They proliferate and activate innate immune system components such as natural killer (NK) cells, neutrophils, and macrophages, and stimulate cytokines expression and secretion. These cytokines in turn activate adaptive immunity through the promotion of Bcells for antibodies production and stimulation of T-cell differentiation to T helper (Th1 and Th2) cells, which mediate cell and humoral immunities, respectively. In this review, the immunotherapeutic potential of oyster mushroom in relation to bioactive compounds produced is shown and this suggests that the oyster mushrooms are one of the most important natural products and functional foods.

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Section: Immunotherapy Of Mushroom Polysaccharides From Pleurotus Spementioning

confidence: 99%

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Oloke¹

2015

IJI

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“…So, oyster mushroom is beneficial to boost the immune system of body. Fraction of β-glucan in this mushroom has potent antitumor activity in Ehrlich tumor and sarcoma 180 (Mowsumi & Choudhary 2010, Facchini et al 2014.…”

Section: Pleurotaceaementioning

confidence: 99%

Healing mushrooms of Uttarakhand Himalaya, India

Bhatt¹

2018

CREAM

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The Himalayan forests of Uttarakhand represent a natural repository for the rich biodiversity of the Indian subcontinent. Forest resources in this region form an integral part of socio-economy and cultural practices. Mushrooms are forest products which have been used as food for a long time but very few for therapeutic purposes, which is associated to the lack of awareness and knowledge. If properly identified, these mystic organisms can be very promising in prevention and cure of various ailments. The present study is a part of macrofungal exploration carried out from 2015-2016. As a result, 15 mushroom species are identified which possess a spectrum of bioactive compounds and therapeutic potential. All of these species are morphologically described along with the habit, habitat and notes on their healing capacities.

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“…Five volumes of ethanol was added to the filtrate and the mixture was maintained at 4ºC for about 24 h and centrifuged (3.400 g). The supernatant was discarded, and the solid residue containing mainly polysaccharides (Precipitate II) was lyophilized and named FII (Facchini et al 2014).…”

Section: Determination Of Glucose Concentration Wasmentioning

confidence: 99%

A polysaccharide fraction extracted from Pleurotus ostreatus mycelial biomass inhibit Sarcoma 180 tumor

Wisbeck

Facchini

Alves

et al. 2017

An. Acad. Bras. Ciênc.

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Fungi of Pleurotus genus have attracted a great interest due to their medicinal properties such as antiinflammatory, antimicrobial and antitumor. These properties are attributed mainly to polysaccharides synthesized by Pleurotus. This work aimed to study the mycelial growth of P. ostreatus in submerged culture, evaluating the influence of the initial concentration of substrate (20 and 40 g/L of glucose) and the pH (4 and 6) on kinetic parameters of production of biomass. The effectiveness of different doses (10, 30 and 50 mg/kg) of a mycelium polysaccharide fraction extracted from P. ostreatus in reducing Sarcoma 180 development in mice was also verified. In the range of this study, maximum concentration of mycelial biomass (about 12.8 g/L) was obtained using 40.0 g/L of glucose, at pH 4.0. The total biomass productivity (Px) was not significantly affected by substrate concentration and pH, reaching values of 0.034 g/L.h. Sarcoma 180 tumor weight was reduced in 74.1, 75.5 and 53.7% when 10, 30 and 50 mg/kg were administered, respectively. These results show the high antitumor potential of intracellular polysaccharide fraction of mycelial biomass of P. ostreatus, particularly at lower doses of 10 and 30 mg/kg.

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Antitumor activity of Pleurotus ostreatus polysaccharide fractions on Ehrlich tumor and Sarcoma 180

Cited by 66 publications

References 20 publications

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Effectiveness of Immunotherapies from Oyster Mushroom (Pleurotus species) in the Management of Immunocompromised Patients

Healing mushrooms of Uttarakhand Himalaya, India

A polysaccharide fraction extracted from Pleurotus ostreatus mycelial biomass inhibit Sarcoma 180 tumor

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