Antitumor activity of Sarcodon aspratus (BERK.) S. ITO and Ganoderma lucidum (FR.) KARST.

Makino, Hírofumi; Yamazaki, Keiko; Murofushi, Sayuri; Konda, C; Ikekawa, Tetsuro

doi:10.1248/bpb1978.12.118

Cited by 49 publications

(26 citation statements)

References 4 publications

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“…These include hepatoprotective (Lin et al, 1993(Lin et al, , 1995, antitumour (Maruyama et al, 1989;Sone et al, 1985), cytotoxic (Lin et al, 1991), antiinflammatory (Lin et al, 1993), antinociceptive (Koyama et al, 1997), platelet aggregation inhibitory (Shimizu et al, 1985;Tao and Peng, 1990), hypoglycaemic (Hikino et al, 1989;Kimura et al, 1988), cholesterol biosynthesis inhibitory (Komoda et al, 1989), cardiovascular/hypotensive (Kabir et al, 1988;Lee and Rhee, 1990), radioprotective Hsu et al, 1990), immunomodulatory Kim et al, 1997;Murasugi et al, 1991;Van der Hem et al, 1995;Wang et al, 1997) and antioxidant (Lin et al, 1995;Wang et al, 1985) effects. In addition, G. lucidum has been reported to induce differentiation of human leukaemic HL-60 cells (Lieu et al, 1992).…”

Section: Discussionmentioning

confidence: 99%

“…Since the aetiology of some of these diseases is in part attributable to oxidative stress induced by ROS, the aforementioned chemoprotective effects of G. lucidum might be associated with its antioxidant properties. Certain fractions of G. lucidum have been shown to possess remarkable antitumour activities (Maruyama et al, 1989;Miyazaki and Nishijima, 1981;Sone et al, 1985;Wang et al, 1997).…”

Section: Introductionmentioning

confidence: 99%

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Inhibition of lipid peroxidation and oxidative DNA damage byGanoderma lucidum

Lee

Kwon

Jeong

et al. 2001

Phytotherapy Research

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Reactive oxygen species (ROS), such as superoxide anions and hydroxyl radicals, are associated with carcinogenesis and other pathophysiological conditions. Therefore, elimination or inactivation of ROS or inhibition of their excess generation may be beneficial in terms of reducing the risk for cancer and other diseases. Ganoderma lucidum has been used in traditional oriental medicine and has potential antiinflammatory and antioxidant activities. In the present study, we tested the amino-polysaccharide fraction (designated as 'G009') from Ganoderma lucidum for the ability to protect against oxidative damage induced by ROS. G009 significantly inhibited iron-induced lipid peroxidation in rat brain homogenates and showed a dose-dependent inactivation of hydroxyl radicals and superoxide anions. It also reduced strand breakage in phiX174 supercoiled DNA caused by UV-induced photolysis of hydrogen peroxide and attenuated phorbol ester-induced generation of superoxide anions in differentiated human promyelocytic leukaemia (HL-60) cells. These findings suggest that G009 from Ganoderma lucidum possesses chemopreventive potential.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Inhibition of lipid peroxidation and oxidative DNA damage byGanoderma lucidum

Lee

Kwon

Jeong

et al. 2001

Phytotherapy Research

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“…Experiments were carried out in a 15 L Horizontal Stirred Tank Reactor (HSTR) of our own construction and design [20]. The cultivation was carried out at 24°C and 5 L/min airflow.…”

Section: Cultivation In Horizontal Stirred Tank Reactormentioning

confidence: 99%

Solid State Cultivation of Hericium erinaceus Biomass and Erinacine: A Production

Gerbec

Gregori²,

Kreft³

et al. 2015

J Bioprocess Biotech

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Hericium erinaceus is a medicinal mushroom producing biologically active metabolite erinacin A. In this research we compared fungal growth and metabolite production in different reactor types and different substrates with added casein peptone and NaCl. Cultivation of fungal biomass was performed in glass jars and horizontal stirred tank reactor. The cultivation in reactor was carried out at 24°C and airflow 5 L/min. Periodical mixing of N = 80 rpm, was used. Solid state substrate based on mixture of husked millet and paddy millet was used. For simultaneous determination of erinacine A and ergosterol contents in a single sample new analytical method was developed. The amount of biomass obtained in glass jars averaged at 100 mg/g ± 12 mg/g, while in horizontal mixing bioreactor it easily raised up to 350 mg/g. The highest erinacin A concentration was detected in substrate with 0.56% NaCl and 3.4% casein peptone content.

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“…Alkalmazzák az alvászavarok helyreállí-tására, fáradékonyság ellen és a szellemi tevékenység fokozására. Alkalmas a kemoterápiás kezelés mellékhatása-inak csökkentésére is [24,25,26,27]. A páfrányfenyő (Ginkgo biloba L.) hatékony szorongáscsökkentő, emellett vérellátási zavarok, szédülés ellen is hatásos.…”

Section: Eredeti Közleményunclassified

Európai és távol-keleti gyógynövények és kivonatok fémelemtartalom-vizsgálata

et al. 2015

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Bevezetés: A szervezetben lévő fémionegyensúly és a táplálkozás során felvett ásványi elemek szervezetre gyakorolt hatása, illetve a fémionterhelés szerepe alapvetően jelentős. Célkitűzés: Kevés kutatás szól arról, hogy a Távol-Keleten alkalmazott gyógynövények fémiontartalma mennyiben hasonló a hazai gyógynövényekéhez tisztasági szempontból és esszenciális fémtartalmukat tekintve, ezért a szerzők Európában és a távol-keleti gyógyászatban alkalmazott gyógy-növények és kivonataik (alkoholos és szárított) mikro-, makroelem-tartalmának meghatározását tűzték ki célul. Mód-szer: Az európai gyógynövények közül a Calendula offi cinalis szirmának, az Achillea millefolium, Epilobium parvifl orum herbájának, az Urtica dioica levelének és a Crataegus monogyna virágos ágvégének, a távol-keleti gyógynövények közül pedig a Cordyceps sinensis, a Ganoderma lucidum, a Ginkgo biloba levelének, a Panax ginseng gyökerének és a Curcuma longa kivonatainak fémiontartalmát határozták meg. Eredmények: A vizsgált drogok és kivonatok tisztasági szempontból megfelelnek az érvényben lévő előírásoknak, esszenciális elemtartalmuk és Ca:Mg arányuk hasonló. Következtetések: A kivonataik kedvező esszenciális fémionforrások és magnéziumtartalmuk is előnyös a Ca:Mg arány magnézium felé eltolódása miatt. Orv. Hetil., 2015, 156(31), 1261-1269. Kulcsszavak: európai gyógynövény, kínai gyógynövény, kalcium, magnézium Investigation of metal element content of some European and Far Eastern herbsIntroduction: Metal elements and their excess intake have signifi cant infl uence on general health. Aim: There is only little information how Far Eastern herbs resemble European's regarding their purity and essential metal element content. The aim of the authors was to determine metal elements in different Chinese and European herbs and extracts. Method: The studied European herbs included Calendula offi cinalis petals, Achillea millefolium, Epilobium parvifl orum herba, Urtica dioica leaves, Crataegus monogyna fl owers while Far Eastern herbs were Cordyceps sinensis, Ganoderma lucidum, Ginkgo biloba leaves, Panax ginseng and Curcuma longa roots. The analysis was performed using inductively coupled plasma optical emission spectroscopy. Results: There was no considerable difference in essential metal elements and the Ca:Mg concentration ratio between European and Far Eastern drugs and extracts. Conclusions: The extracts are preferential metal element sources and their magnesium content are also advantageous, because of a shift of the Ca:Mg concentration ratio towards magnesium.

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Antitumor activity of Sarcodon aspratus (BERK.) S. ITO and Ganoderma lucidum (FR.) KARST.

Cited by 49 publications

References 4 publications

Inhibition of lipid peroxidation and oxidative DNA damage byGanoderma lucidum

Inhibition of lipid peroxidation and oxidative DNA damage byGanoderma lucidum

Solid State Cultivation of Hericium erinaceus Biomass and Erinacine: A Production

Európai és távol-keleti gyógynövények és kivonatok fémelemtartalom-vizsgálata

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