Antitumor activity of some azine and hydrazone derivatives of 1,4-dimethoxy-2-butanone

Synthesis and Solvatochromic Studies on the Uv-Absorption Spectra of Symmetrical Azine Derived from 2,4-Dichlorobenzaldehyde

“…Azines may also possess biological features as antifungal, antibacterial, antihypertensive and anticancer activities [4][5][6][7][8][9]. It has been demonstrated that a variety of heterocyclic compounds exhibit pharmacological properties [10][11]. They make good drug development candidates for the pharmacology sector.…”

Fabrication of acid‐labile poly(2‐hydroxyethyl methacrylate) nanoparticles using aldazine‐based crosslinker as pH‐sensitive drug nanocarriers

“…Azines, R 1 R 2 CNNCR 1 R 2 , which can also be considered as NN‐linked diimines, are extremely useful organic compounds derived by condensation of hydrazine with an aldehyde or a ketone and they can be considered as 2,3‐diaza analogues of butadiene 1 . Enormous research has been done on various types of azines, both symmetrical and asymmetrical, because of their application in different fields such as nonlinear optical materials, 2,3 biological application, pharmaceutical activities, 2‐7 and their potential applications in bond formation, 8,9 polymerizations, 10‐14 and in the design of liquid crystals 15‐22 . It is noteworthy that the NN bond conformation in azines might be s‐cis , s‐trans , which are both planar, or gauche , while for asymmetric azines, four possible configurations could be considered.…”

Spectral and conformational studies on 3-pyridinealdazine by DFT approach

“…The chemistry of carbon nitrogen double bond of hydrazone is becoming the backbone of condensation reaction in benzo-fused Nheterocycles [3] also it constitutes an important class of compounds for new drug development [4]. A number of heterocyclic compounds have been shown to possess pharmacological activities [5][6][7]. Azines, R1R2C=N-N=CR1R2, have achieved great significance in organic synthesis [8][9][10][11][12].…”