Antitumor and antimetastatic activity of fucoidan, a sulfated polysaccharide isolated from the Okhotsk sea Fucus evanescens brown alga

Abstract

Antitumor and antimetastatic activities of fucoidan, a sulfated polysaccharide isolated from Fucus evanescens (brown alga in Okhotsk sea), was studied in C57Bl/6 mice with transplanted Lewis lung adenocarcinoma. Fucoidan after single and repeated administration in a dose of 10 mg/kg produced moderate antitumor and antimetastatic effects and potentiated the antimetastatic, but not antitumor activities of cyclophosphamide. Fucoidan in a dose of 25 mg/kg potentiated the toxic effect of cyclophosphamide.

Evaluation of acute and subchronic toxicity of a non-anticoagulant, but antithrombotic algal heterofucan from the Spatoglossum schröederi in Wistar rats

“…In fact, seaweeds are a great source of sulfated polysaccharides expressing anticoagulant, cytotoxic, antitumor, antimetastic activities (Alekseyenko et al, 2007;Li et al, 2008).…”

Antitumor activity of <i>Chondrococcus hornemanni</i> and <i>Spyridia fusiformis</i> on Dalton’s lymphoma ascites in mice

“…Yamamoto et al (1987) and Sheu et al (1996) reported that oral consumption of several seaweeds significantly decreased the incidence of carcinogenesis in vivo. Alekseyenko et al (2007) suggested that polysaccharide of Fucus evanescens has antitumor and antimetastatic activity in C57BI/6 mice with transplanted Lewis lung adenocarcinoma. Down-regulating tissue factor expression, Grateloupia longifolia polysaccharide inhibits angiogenesis in HMEC-1 endothelial cells (Zhang et al, 2006).…”

Fucoidans from Brown Alga Fucus evanescens: Structure and Biological Activity

“…Fucoidan (10 mg/kg) alone possess moderate antitumor and antimetastatic effects. In addition, this fucoidan potentiates the antimetastatic but not antitumor activities of cyclophosphamide (drug used for chemotherapy) and, at 25 mg/kg, increases the toxic effect of cyclophosphamide (Alekseyenko et al, 2007).…”