Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea)

Moro, Antônio C.; Mauro, Antônio Eduardo; Netto, Adelino V.G.; Ananias, Sandra R.; Quilles, Marcela B.; Carlos, Iracilda Zeppone; Pavan, Fernando Rogério; Leite, Clarice Q. F.; Hörner, Manfredo

doi:10.1016/j.ejmech.2009.06.032

Cited by 65 publications

(24 citation statements)

References 37 publications

(63 reference statements)

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“…Motivated by the aforementioned findings, and as a part of our continuing research program in the field of coordination and biological chemistry of azolyl complexes [13][14][15][16][17][18][19][20][21][22], we present herein the evaluation of the in vitro cytotoxic activity of the compounds [PdCl 2 (tdmPz)] (1), [PdBr 2 (tdmPz)] (2), [PdI 2 (tdmPz)] (3) and [Pd(SCN) 2 (tdmPz)] (4) (tdmPz ¼ 1-thiocarbamoyl-3,5-dimethylpyrazole) against murine mammary adenocarcinoma (LM3 and LMM3) and lung adenocarcinoma (LP07) as well towards normal murine peritoneal exudate cells (PEC). In addition, this paper also describes the synthesis of two new compounds [PdBr 2 (tdmPz)] (2) and [PdI 2 (tdmPz)] (3), which were characterized by means of elemental analysis, IR, UV-Vis, 1 H and 13 C{ 1 H} NMR spectroscopy.…”

Section: Introductionmentioning

confidence: 99%

3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

Rocha

Barra

Netto

et al. 2010

European Journal of Medicinal Chemistry

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Section: Introductionmentioning

confidence: 99%

3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

Rocha

Barra

Netto

et al. 2010

European Journal of Medicinal Chemistry

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“…Despite the fact that antitumor [11], antibacterial [12], antitrypanosomal [13], antifungal [14], antiherpetic [15], anti-inflammatory [16], antiamoebic [17] and anti-tubercular properties [18] of palladium(II) compounds have been the subject of many reports, studies on the biological activity of isonicotinamide-based Pd(II) complexes remain unknown in literature.…”

Section: Introductionmentioning

confidence: 99%

“…The variation of the labile Cl ligand in metal complexes by pseudohalides has been extensively used [18,19]. Such replacement is expected to decrease the substitution rates for pseudohalides compared with chlorido ligands which may contribute to stabilization and biological activity in some of these Pd(II) species [20].…”

Section: Introductionmentioning

confidence: 99%

Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)2]

Souza

Stevanato

Treu-Filho

et al. 2010

European Journal of Medicinal Chemistry

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“…N, N'-Disubstituted thioureas are of great importance due to their ability to concentrate and separate the toxic metals. Therefore metal complexes of aroyl thiourea are excellent candidates to use as lixiviant, chromogenic ionophore towards fluoride ion detection, in opto-electric modulation, for developing polymer membrane ion-selective e-mail: amaramumtaz@ciit.net.pk electrode and also exhibit great anti-bacterial, anti-fungal, anti-tumor, antiviral, anti-mycobacterial and also posses urease inhibition activities (Arslan et al 2006;D'Cruz OJ 2003;Del CR 2002;Dhumane NR 2006;Moro AC 2009;Sun MZ 2008;Tremblay L 1996). Thioureas and their derivative are considered as very effective inhibitory active agents against the urease enzyme (Aslam MA 2011).…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization and Urease Inhibition Studies of Transition Metal Complexes of Thioureas Bearing Ibuprofen Moiety

Mumtaz

Arshad

Saeed

et al. 2018

J. Chil. Chem. Soc.

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Starting from ibuprofen, a non-steroidal anti-inflammatory drug, N,N'-disubstituted thiourea derivatives were synthesized by refluxing the acid chloride of ibuprofen with potassium thiocyanate followed by substituted anilines to get N-2- (4-(2-methylpropyl) phenyl)propionoyl-N´-(2´-bromophenyl) thiourea (1), N-2-(4-(2-methylpropyl)phenyl)propionoyl-N´-(2´-chlorophenyl) thiourea (2) and N-2-(4-(2-methylpropyl)phenyl)propionoyl-N´-(3´,4´-dichlorophenyl) thiourea (3).Metal complexes (4-15) of (1-3) were synthesized by refluxing it with one equivalence salts of Co (ΙΙ), Ni(ΙΙ), Pb(ΙΙ) and Cu(Ι). Structures of all the synthesized thiourea ligands and their metal complexes were determined by FTIR and 1 HNMR spectroscopy. Shift in stretching frequency in FTIR and resonance frequency in 1 HNMR spectroscopic data suggested that the ligands and metal are coordinated to afford respective metal complexes M[L] n . The synthesized compounds were tested against urease enzyme and the results were compared with standard thiourea, as positive control. Most of the investigated compounds showed potential inhibitory activity against Jack bean urease. Compound 5 was found to be the most potent urease inhibitor with IC 50 of 14.6 µM, whereas compounds 8, 11 and 12 possessed potent urease inhibition. The tested compounds can be taken as lead molecules for gastrointestinal ulcer therapy.Key words: Amides, Thioureas, Metal complexes, Ibuprofen, Urease. INTRODUCTIONUrease (urea aminohydrolase E.C. 3.5.1.5) is nickel containing metalloenzyme which belongs to the super family of amidohydrolases and phosphotriestreases, responsible for the hydrolytic decomposition of urea (Holm 1997). It was the first enzyme which crystallized from the plant source Canavalia ensiformis and was also the first protein containing nickel in the active site (Saeed et al. 2014;Saeed et al. 2013). Because of these characteristics urease is considered as a paradigm in the development of inorganic biochemistry. Urease catalyses the hydrolysis of urea in different plants, algae, fungi, and microorganisms to produce ammonia and carbamate (Mobley HL 1989). Enzyme catalysed hydrolysis-process occurred at a rate of approximately 10 14 times the rate of the unanalyzed reaction and considered as the final step of nitrogen metabolism in all living organisms. Different types of urease enzymes can be isolated from bacteria, fungi, algae and plants but enzymatic activity is same due to the occarance of the same order of amino acid (Bacanamwo M 2002;Benini S 1999). Urease activity due to infectious microorganism is the major reason for many deceases in humans such as development of infection stones, pyelonephritis, stomach and peptic ulcer, urinary catheter encrustation, and hepatic com (Gripenberg-Lerche C 2000; Mobley et al. 1995;Mobley HL 1989). To overcome these diverse types of problems, urease inhibitors have received special attention over the past few years. These inhibitors generally divided into two classes, substrate structural analogs like hydroxamic acid (Ko...

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Antitumor and antimycobacterial activities of cyclopalladated complexes: X-ray structure of [Pd(C2,N-dmba)(Br)(tu)] (dmba =N,N-dimethylbenzylamine, tu = thiourea)

Cited by 65 publications

References 37 publications

3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

3,5-Dimethyl-1-thiocarbamoylpyrazole and its Pd(II) complexes: Synthesis, spectral studies and antitumor activity

Antimycobacterial and antitumor activities of Palladium(II) complexes containing isonicotinamide (isn): X-ray structure of trans-[Pd(N3)2(isn)2]

Synthesis, Characterization and Urease Inhibition Studies of Transition Metal Complexes of Thioureas Bearing Ibuprofen Moiety

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