Antitumor and Cytotoxic Effects ofPhyllanthus polyphylluson Ehrlich Ascites Carcinoma and Human Cancer Cell Lines

Effect of Balanites aegyptiaca on Ehrlich Ascitic carcinoma growth and metastasis in Swiss mice

“…The tumor line was maintained by serial intraperitoneal transplantation of 2.5 × 10 6 cells in 0.2 ml of 0.9% NaCl/mouse. Tumor growth was observed within 4-6 days following transplantation (Rajkapoor et al, 2007). • Tumor cells counts were done in a Neubauer hemocytometer using the trypan blue dye.…”

“…• Group IV (tumor bearing) inoculated intraperitoneally with a single dose of Ehrlich tumor cell line at (10) 6 cells in 0.2 ml of 0.9% NaCl/mouse for induction of tumor. The tumor growth was observed within 4-6 days following transplantation (Rajkapoor et al, 2007). After the last dose, the animals were fasting for 18-h. Six mice from each group were sacrificed by over dose of diethyl ether anesthesia for the study of antitumor activity, hematological and liver biochemical parameters.…”

Evaluation ofPhyllanthus polyphyllusL. Extract and its Active Constituent as a Source of Antifungal, Anti-Aflatoxigenic, and Antioxidant Activities

“…article, the potential antifungal activity of P. polyphyllus and inhibitory activity towards aflatoxin biosynthesis is discussed, with special reference to its bioactive component. Several prior studies have highlighted the P. polyphyllus for its various bioactivities such as anti-inflammatory, [18] antitumour, [21] cytotoxic, [21,22] and hepatoprotective activities. [23,24] The 4-o-MGA has been well reported as active constituent for such bioactivities.…”

“…The antioxidant capacity of 4-o-MGA was greater than the standard BHT, however, the activity of ME was close to the BHT with regardless of the concentration conditions. Rajkapoor et al [21] reported the hepatoprotective and antioxidant activity of P. polyphyllus in acetaminophen-induced hepatotoxicity in rat model. Srirama et al [22] demonstrated the antioxidant activity of crude extract of P. polyphyllus, but the active constituent responsible for such activities are not reported.…”

“…[19] The genus Phyllanthus contains highly valued medicinal plants which produce a variety of secondary metabolites including flavonoids, phenolic acids, alkaloids, lignans, and tannins, have long been extensively used in folk medicine all over the world. [20] P. polyphyllus has been investigated for their various bioactive properties such as anti-inflammatory, [18] anti-tumour, [21] cytotoxic, [21,22] and hepatoprotective activities. [23,24] Species of these plant genera are used in folk medicine and consumed as healthy ingredients, they could also be useful in preventing mould growth and mycotoxin contamination due to their antifungal properties.…”