Antitumor and immunomodulatory activity of <i>Inonotus obliquus</i>

Staniszewska, Justyna; Szymański, Marcin; Ignatowicz, Ewa

doi:10.1515/hepo-2017-0013

Cited by 18 publications

(9 citation statements)

References 53 publications

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“…Because of the special conditions required for its growth, indigenous people have variously described these fungi as “black diamonds in the forest”, “fantastic mushrooms”, and other namesakes [2]. I. obliquus has attracted increasing attention worldwide due to its high nutritional and medicinal values, as well as its anti-tumor [3], anti-oxidant [4], immunomodulatory activities [5], anti-asthma [6], and other medicinal properties [7]. Several studies have shown that polysaccharides are one of the major bioactive constituents that are present in fresh I. obliquus [8].…”

Section: Introductionmentioning

confidence: 99%

Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus

Liu

Liang

et al. 2019

Molecules

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Polysaccharides from the immunomodulatory medicinal mushroom Inonotus obliquus (IOPS) were extracted and purified using three-phase partitioning (TPP), which is an efficient, fast, safe, and green purification technique. An optimal extraction procedure that gave a good 2.2% isolated yield was identified, using the following protocol: a solid-liquid ratio of 1 g to 12 mL; mass fraction of (NH4)2SO4 20% (w/v); 11 mL t-butanol; pH 8.0; temperature 30 °C; and extraction time 30 min. The purified IOPS was shown to be a proteoglycan of 40 kDa molecular weight comprising of d-galactose, d-glucose, d-xylose, and d-mannose in a molar ratio of 2.0:3.5:1.0:1.5. The purified IOPS displayed strong free-radical scavenging abilities, antioxidant activities, and immunological activity in vitro. IOPS’ Trolox antioxidant equivalent capacity and ferric-reducing ability of plasma were 251.2 μmol Trolox/g sample and 1040.5 μmol Fe2+/g sample, respectively, with the activity of its immunomodulatory behavior shown to be gradient dependent.

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Section: Introductionmentioning

confidence: 99%

Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus

Liu

Liang

et al. 2019

Molecules

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“…The anticancer, antioxidative, immunomodulating activities of Ganoderma lucidum [70] fruiting bodies, which contain the heteroglycan Glycopeptide, have been reported; and the anticancer and immunomodulating properties of Lentinus edodes [69] fruiting bodies, which contain glucan, are well established. Pleurotus tuber-regium [71] fruiting bodies contain β-D-glucan, which displays anticancer as well as hepatoprotective properties.…”

Section: A Snapshot Of the Application Of Mushroom Polysaccharide-bas...mentioning

confidence: 99%

Mushroom Polysaccharide-Assisted Anticarcinogenic Mycotherapy: Reviewing Its Clinical Trials

et al. 2022

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Of the biologically active components, polysaccharides play a crucial role of high medical and pharmaceutical significance. Mushrooms have existed for a long time, dating back to the time of the Ancient Egypt and continue to be well explored globally and experimented with in research as well as in national and international cuisines. Mushroom polysaccharides have slowly become valuable sources of nutraceuticals which have been able to treat various diseases and disorders in humans. The application of mushroom polysaccharides for anticancer mycotherapy is what is being reviewed herein. The widespread health benefits of mushroom polysaccharides have been highlighted and the significant inputs of mushroom-based polysaccharides in anticancer clinical trials have been presented. The challenges and limitation of mushroom polysaccharides into this application and the gaps in the current application areas that could be the future direction have been discussed.

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“…Other mushrooms exert an anti-inflammatory effect less directly by quenching damaging free radicals and counteracting oxidation. For instance, Chaga mushrooms (Inonotus obliquus) have antioxidant activity, protecting cells against oxidative damage [103,104]. Oyster mushrooms (Pleurotus ostreatus) have an antioxidant effect as well [105].…”

Section: Anti-inflammatory Role Of Mushroomsmentioning

confidence: 99%

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

et al. 2021

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The defining characteristics of the traditional Sub-Saharan Africa (SSA) cuisine have been the richness in indigenous foods and ingredients, herbs and spices, fermented foods and beverages, and healthy and whole ingredients used. It is crucial to safeguard the recognized benefits of mainstream traditional foods and ingredients, which gradually eroded in the last decades. Notwithstanding poverty, chronic hunger, malnutrition, and undernourishment in the region, traditional eating habits have been related to positive health outcomes and sustainability. The research prevailed dealing with food availability and access rather than the health, nutrition, and diet quality dimensions of food security based on what people consume per country and on the missing data related to nutrient composition of indigenous foods. As countries become more economically developed, they shift to “modern” occidental foods rich in saturated fats, salt, sugar, fizzy beverages, and sweeteners. As a result, there are increased incidences of previously unreported ailments due to an unbalanced diet. Protein-rich foods in dietary guidelines enhance only those of animal or plant sources, while rich protein sources such as mushrooms have been absent in these charts, even in developed countries. This article considers the valorization of traditional African foodstuffs and ingredients, enhancing the importance of establishing food-based dietary guidelines per country. The crux of this review highlights the potential of mushrooms, namely some underutilized in the SSA, which is the continent’s little exploited gold mine as one of the greatest untapped resources for feeding and providing income for Africa’s growing population, which could play a role in shielding Sub-Saharan Africans against the side effects of an unhealthy stylish diet.

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Antitumor and immunomodulatory activity of Inonotus obliquus

Cited by 18 publications

References 53 publications

Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus

Three-Phase Partitioning for the Extraction and Purification of Polysaccharides from the Immunomodulatory Medicinal Mushroom Inonotus obliquus

Mushroom Polysaccharide-Assisted Anticarcinogenic Mycotherapy: Reviewing Its Clinical Trials

Mushroom Nutrition as Preventative Healthcare in Sub-Saharan Africa

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