Antitumor and immunomodulatory activity of polysaccharides from the root of Limonium sinense Kuntze

Tang, Xin; Ling, Yan; Gao, Jing; Yang, Xiaolan; Xu, Yongxin; Ge, Haiyan; Yang, Haidong

doi:10.1016/j.ijbiomac.2012.08.037

Cited by 45 publications

(29 citation statements)

References 8 publications

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“…These results indicated that the anti-tumor activity of SOP may be achieved through immune potentiation. (108) These results were confirmed by other researchers using different CMM, such as polysaccharide from Limonium sinense Kuntez, (109) Lilium sp., (110) G. lucidum (111) and Weikangfu Granule ( ), a drug preparation used to treate gastric cancer and consisting of Curcuma wenyujin, Astralagus membranaceous, Glycyrrhiza in ate, Poria coco, (112) Decoction ( ), a CMM prescription consisting of nine herbs including Astragalus membranaeus, Panax ginseng and Sculellaria baicalensis, has been classically used for treating fever and pulmonary disorders. Tumor burden and losses of muscle mass were found to be significantly decreased when 5-FU was combined with this Chinese prescription, suggesting that the combination of S. baicalensis and QYD is able to ameliorate cachectic symptoms and positively stimulate anti-tumor immunity in mice undergoing chemotherapy.…”

Section: Angiogenesis and Lymphangiogenesissupporting

confidence: 71%

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Sun

Gao

et al. 2017

Chin. J. Integr. Med.

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Infiltration of the tumor microenvironment (TME) by immune and inflammatory cells is involved in promoting tumorigenesis, tumor progression, local invasion and metastasis.(1) Tumor-associated macrophages (TAMs), a prominent and abundant inflammatory component of solid and hematological malignancies, express a pro-and anti-tumor effect in all stages of carcinogenesis. Asian region. According to the theory of Chinese medicine (CM) and its practice, some Asian region. According to the theory of Chinese medicine (CM) and its practice, some prescriptions of CM regulate the body's internal environment possibly including the prescriptions of CM regulate the body's internal environment possibly including the remodeling the tumor microenvironment (TME). Here we brie y summarize the pivotal remodeling the tumor microenvironment (TME). Here we brie y summarize the pivotal effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis effects of TAMs in shaping the TME and promoting tumorigenesis, invasion, metastasis and immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antiand immunosuppression. Furthermore, we illustrate the effects and mechanisms of CMM targeting TAMs in antitumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, tumor therapy. Finally, we reveal the CMM's dual-regulatory and multi-targeting functions on regulating TAMs, and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy. and hopefully, provide the theoretical basis for CMM clinical practice related to cancer therapy.

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Section: Angiogenesis and Lymphangiogenesissupporting

confidence: 71%

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Sun

Gao

et al. 2017

Chin. J. Integr. Med.

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“…Assay for splenocyte proliferation was carried out according to the previous method [18]. Spleens collected from tumor-bearing mice and normal control mice under aseptic conditions were chopped into small pieces and passed through a fine steel mesh to obtain a homogeneous cell suspension.…”

Section: Assay For Splenocyte Proliferationmentioning

confidence: 99%

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Chen

Huang

Cui

et al. 2015

International Journal of Biological Macromolecules

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“…Numerous researches demonstrated that plenty of natural polysaccharides were good at protecting human bodies from oxidative damage in the growth and development of living organism [7–9]. Therefore, natural polysaccharides are considered as a potential resource of novel antioxidants, and the mechanism of polysaccharide are in need of further research [6, 10]. …”

Section: Introductionmentioning

confidence: 99%

Extraction, purification, characterization and antioxidant activities of polysaccharides from Ramaria botrytis (Pers.) Ricken

2017

Chemistry Central Journal

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Background Ramaria botrytis (Pers.) Ricken, a member of the family Clavariaceae, has been widely prescribed for anti-aging and improving immunity. To extract and purify the polysaccharides, the main constituent of the fruiting-body, from R. botrytis and explore antioxidant activities was great significant.Results Ramaria botrytis polysaccharides (RBP) was extracted with water at 88.47 °C for 1.42 h with a solution to sample ratio of 10.94 mL g−1 employing response surface methodology. Four purified fractions, RBP-1, RBP-2, RBP-3, and RBP-4, were obtained from column chromatography of DEAE-52 and Sephadex G-100. Among these four purified fractions, RBP-1, RBP-2, RBP-4 were mainly composed of glucose, while RBP-3 contained 41.36% mannose and 28.96% glucose. The molecular weights of RBP-1, RBP-2, RBP-3 and RBP-4 were 6.48, 36.12, 96.72 and 8.34 kDa, respectively. These four fractions are also tested for antioxidant activities in vitro, RBP-4 exhibited strong assay of reducing power and high scavenging activity on DPPH radical, while RBP-3 showed the stronger ability of hydroxyl radical scavenging activity.ConclusionsResponse surface methodology was successfully applied to optimize the ultrasonic extraction of polysaccharides from R. botrytis. RBP is an efficient natural antioxidant.

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Antitumor and immunomodulatory activity of polysaccharides from the root of Limonium sinense Kuntze

Cited by 45 publications

References 8 publications

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Targeting tumor-associated macrophages by anti-tumor Chinese materia medica

Purification, characterization and biological activity of a novel polysaccharide from Inonotus obliquus

Extraction, purification, characterization and antioxidant activities of polysaccharides from Ramaria botrytis (Pers.) Ricken

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