Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice

Mahmoud, Hayam; Said, Mohamed M.; Morcos, Nadia Y.S.; Gawish, Mona A El; Ismail, Amel F.M.

doi:10.1177/15347354211021920

Cited by 19 publications

(6 citation statements)

References 110 publications

(146 reference statements)

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“…While biosynthesized ZnO NPs were effective on the proliferation of the breast cancer (MCF7) cells with IC 50 61.92µM compared with 248.72µM for chemically synthesized ZnO NPs, (Fig. 7B and D) which in agreement with Sayed et al [41] who discovered that dose-dependent effects were observed MCF7 and HepG2 cancer cells treated with varied dosages of ZnO NPs had a decrease in viability and a steady increase in toxicity. Because of this, "green" or biosynthesized nanoparticles (NPs) exhibit greater stability and activity than NPs made using more traditional methods [42].…”

Section: Cytotoxicity Assay Of Zno Nps Using (Mtt) Assay Protocolsupporting

confidence: 88%

WITHDRAWN: Cytotoxicity and wound healing efficacy of biosynthesis ZnO Nanoparticles Using Aspergillus niger against Multidrug Resistant Pseudomonas aeruginosa

Moustafa,

Hewedy,

Abdelbary

et al. 2023

Preprint

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Background Critically ill patients, particularly burn patients, are at substantial risk from Pseudomonas aeruginosa infection, which is a common source of healthcare-acquired infections. The rise of multidrug resistant pathogens is increasing, making control difficult. Infectious infections continue to be a public health concern worldwide, owing to growing resistance to antimicrobial agents. The current study was designed to assess the effectiveness of biologically produced zinc oxide nanoparticles (ZnO-NPs) in both vitro and vivo against MDR P. aeruginosa. Results Four soil samples were gathered from various sites. Fifteen fungus isolates were identified and tested for their ability to produce green ZnO NPs. The antibacterial activity of the biosynthesized ZnO NPs was evaluated against P. aeruginosa. Using morphological and molecular methods, a powerful fungal isolate in producing ZnO NPs was identified. The isolate of the fungus was recognized as A. niger. ZnO-NPs were produced biologically and UV-vis spectroscopy, Fourier-transform infrared (FT-IR), Transmission Electron Microscopy (TEM), X-ray diffraction (XRD), and Zeta potential and particle size analysis were then used to characterize the samples. The biosynthesized ZnO NPs had no impact on normal melanocyte mammalian cell line (Hfb4) with IC50 365.64µM, had an antitumor effect on breast cancer cell lines (Mcf7) with IC50 61.92µM and displayed antiviral effects against the herpes simplex virus type 1 (Hvs1) (91.4%) at 250 µg/ml. Using female albino rats infected with P. aeruginosa, the antibacterial efficacy and wound healing effectiveness of synthesized ZnO NPs were assessed and their activity was compared with different agents including saline solution alone, fusidic acid (20 ml/g), and chemically synthesized ZnO NP. In comparison to other agents employed, the findings demonstrated that biosynthesized ZnO NPs have a significant impact on the process of wound healing. An estimation of the oxidative stress and immune response in rats given biosynthesized ZnO NP treatments revealed that oxidative stress and inflammation were reduced because of the presence of infection. Three weeks later, histopathological examination was performed to assess the wound healing development. Conclusions The outcomes showed after 14 days, ZnO NPs are highly effective against MDR P. aeruginosa and accelerate the healing of wounds.

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Section: Cytotoxicity Assay Of Zno Nps Using (Mtt) Assay Protocolsupporting

confidence: 88%

WITHDRAWN: Cytotoxicity and wound healing efficacy of biosynthesis ZnO Nanoparticles Using Aspergillus niger against Multidrug Resistant Pseudomonas aeruginosa

Moustafa,

Hewedy,

Abdelbary

et al. 2023

Preprint

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“…Plant-derived natural products have incredible potential to control cancer cell growth . Previous studies confirmed that the ASLE contained flavonoids, alkaloids, saponins, tannins, glycosides, steroids, phenols, and various acetogenin compounds and demonstrated a various array of pharmacological activities involving antioxidant, anti-cancer, and anti-inflammatory properties. , Nowadays, plants are performing a remarkable role in nanoparticle synthesis . To ameliorate cancer therapeutic protocols, the current study was implemented to determine the antitumor efficacy and hepato-renal protective effect of ASLELN against Erhlich Ascites Carcinoma (EAC) in mice.…”

Section: Discussionmentioning

confidence: 99%

“… 17 , 18 Nowadays, plants are performing a remarkable role in nanoparticle synthesis. 19 To ameliorate cancer therapeutic protocols, the current study was implemented to determine the antitumor efficacy and hepato-renal protective effect of ASLELN against Erhlich Ascites Carcinoma (EAC) in mice.…”

Section: Discussionmentioning

confidence: 99%

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

et al. 2022

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Current research is focused on cancer treatments other than chemotherapy medications, particularly those derived from natural sources. The goal of this work was to look at the anticancer and biomarker properties of a methanolic extract of Annona squamosa leaves and their extract-loaded noisome. A. squamosa leaves extract and their leaves extract-loaded noisome were prepared. Transmission electron microscopy was used to screen the size of the niosomes loaded with the A. squamosa L. leaves extract. The tumor size, blood picture (hemoglobin, red blood cells, white blood cells), liver functions, kidney function, oxidative stress, and inflammatory markers were evaluated to assess the potential anticancer activity of the A. squamosa leaves extract and A. squamosa leaves extract-loaded noisome in Ehrlich ascites carcinoma. A. squamosa L. leaves extract was found to be an effective anticancer treatment. The protective effect of the loaded extract showed more significant results. All treated groups showed a lower tumor volume compared to the positive control. Liver and kidney functions were improved, and inflammatory markers were decreased. Oxidative stress was improved in tumor, liver, and kidney tissues. A. squamosa leaves contain major anticancer compounds that in general help most enzymes of the liver and kidney and other injured organs to return to their normal levels.

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“…The ZnO NPs’ antioxidant potential was also confirmed through the continual reduction of zinc ions. The ZnO NPs were proven to be effective in the treatment of UTIs and fungi infections and, even further, showed great antitumor action [ 167 , 168 ]. Due to these particular advantages, it would be worthwhile to pursue further research of its properties and applications in industries such as food processing, pharmaceuticals, and cosmetics, in which the ZnO NPs could have a positive impact [ 160 , 169 , 170 ].…”

Section: Nanotechnology Used As a Diagnostic Methods And In Antimicro...mentioning

confidence: 99%

Nanotechnology Involved in Treating Urinary Tract Infections: An Overview

et al. 2023

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Considered as the most frequent contaminations that do not require hospitalization, urinary tract infections (UTIs) are largely known to cause significant personal burdens on patients. Although UTIs overall are highly preventable health issues, the recourse to antibiotics as drug treatments for these infections is a worryingly spread approach that should be addressed and gradually overcome in a contemporary, modernized healthcare system. With a virtually alarming global rise of antibiotic resistance overall, nanotechnologies may prove to be the much-needed ‘lifebuoy’ that will eventually suppress this prejudicial phenomenon. This review aims to present the most promising, currently known nano-solutions, with glimpses on clinical and epidemiological aspects of the UTIs, prospective diagnostic instruments, and non-antibiotic treatments, all of these engulfed in a comprehensive overview.

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Antitumor and Radiosensitizing Effects of Zinc Oxide-Caffeic Acid Nanoparticles against Solid Ehrlich Carcinoma in Female Mice

Cited by 19 publications

References 110 publications

WITHDRAWN: Cytotoxicity and wound healing efficacy of biosynthesis ZnO Nanoparticles Using Aspergillus niger against Multidrug Resistant Pseudomonas aeruginosa

WITHDRAWN: Cytotoxicity and wound healing efficacy of biosynthesis ZnO Nanoparticles Using Aspergillus niger against Multidrug Resistant Pseudomonas aeruginosa

Annona squamosa L. Extract-Loaded Niosome and Its Anti-Ehrlich Ascites’ Carcinoma Activity

Nanotechnology Involved in Treating Urinary Tract Infections: An Overview

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