Antitumor effect of soybean lectin mediated through reactive oxygen species-dependent pathway

Panda, Prashanta Kumar; Mukhopadhyay, Subhadip; Behera, Birendra; Bhol, Chandra Sekhar; Dey, Sandeep Kumar; Das, Durgesh Nandini; Sinha, Niharika; Bissoyi, Akalabya; Pramanik, Krishna; Maiti, Tapas K.; Bhutia, Sujit K.

doi:10.1016/j.lfs.2014.07.004

Cited by 63 publications

(44 citation statements)

References 29 publications

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“…The Eutirucallin treatments reduced colony numbers to 169 ± 11 ( P < 0.05), 109 ± 4 ( P < 0.05) and 76 ± 4 ( P < 0.05) at concentrations of 25, 50, and 100 μg/ml respectively (Figure 5B). Similar results have demonstrated that plant compounds are able to inhibit the growth of different tumor cell lines and that Peanut agglutinin and Soybean lectins significantly decrease HeLa cell colony formation (Mukhopadhyay et al, 2014; Panda et al, 2014). …”

Section: Resultssupporting

confidence: 58%

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

Palharini

Richter

Silva

et al. 2017

Front. Cell. Infect. Microbiol.

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Eutirucallin is a lectin isolated from the latex of Euphorbia tirucalli, a plant known for its medical properties. The present study explores various characteristics of Eutirucallin including stability, cytotoxicity against tumor cells, antimicrobial and antiparasitic activities. Eutirucallin was stable from 2 to 40 days at 4°C, maintained hemagglutinating activity within a restricted range, and showed optimal activity at pH 7.0–8.0. Eutirucallin presented antiproliferative activity for HeLa, PC3, MDA-MB-231, and MCF-7 tumor cells but was not cytotoxic for non-tumorigenic cells such as macrophages and fibroblasts. Eutirucallin inhibited the Ehrlich ascites carcinoma in vivo and it was also observed that Eutirucallin inhibited 62.5% of Escherichia coli growth. Also, Eutirucallin showed to be effective when tested directly against Toxoplasma gondii infection in vitro. Therefore, this study sheds perspectives for pharmacological applications of Eutirucallin.

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Section: Resultssupporting

confidence: 58%

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

Palharini

Richter

Silva

et al. 2017

Front. Cell. Infect. Microbiol.

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“…Additionally, the Chinese herbal remedy diterpenoid oridonin, which is purified from Rabdosia rubescens, was found to induce autophagic death in MCF-7 cells [91]. Interestingly, we recently showed that plant lectins, including those found in peanuts [92] and soybeans [93], are no longer humble culinary items, instead they act as therapeutic agents by inducing both autophagic death and apoptosis. Moreover, we determined that concanavalin A downregulated the PI3K/Akt/mTOR pathway while upregulating the MEK/ERK pathway to induce autophagic cell death in HeLa cells [94].…”

Section: Potent Natural Molecules Inducing Autophagic Cell Deathmentioning

confidence: 99%

Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics

Panda

Mukhopadhyay

Das

et al. 2015

Seminars in Cell & Developmental Biology

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127

115

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“…The ability of lectins to inhibit the growth of cancer cells in vitro is well documented in the literature and some examples are listed in Table 1 [13–21, 23–25, 27–29, 89, 111, 178–181]. In addition, to reduce cell proliferation, lectins may interact with receptors and other molecules present in cell surface and/or cytosol, activating cell death pathways.…”

Section: Lectins As Anticancer Agentsmentioning

confidence: 99%

“…The proapoptotic gene Bax was expressed intensively in cells treated with P. sativum lectin [28, 180]. The seed lectin from Glycine max caused 82.95% inhibition of Dalton's lymphoma in mice that received it through intraperitoneal injection; induction of autophagy and apoptosis, with activation of ROS production, was detected [25]. …”

Section: Lectins As Anticancer Agentsmentioning

confidence: 99%

Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

Coelho

Silva

Lima

et al. 2017

Evidence-Based Complementary and Alternative Medicine

161

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Lectins are proteins extensively used in biomedical applications with property to recognize carbohydrates through carbohydrate-binding sites, which identify glycans attached to cell surfaces, glycoconjugates, or free sugars, detecting abnormal cells and biomarkers related to diseases. These lectin abilities promoted interesting results in experimental treatments of immunological diseases, wounds, and cancer. Lectins obtained from virus, microorganisms, algae, animals, and plants were reported as modulators and tool markers in vivo and in vitro; these molecules also play a role in the induction of mitosis and immune responses, contributing for resolution of infections and inflammations. Lectins revealed healing effect through induction of reepithelialization and cicatrization of wounds. Some lectins have been efficient agents against virus, fungi, bacteria, and helminths at low concentrations. Lectin-mediated bioadhesion has been an interesting characteristic for development of drug delivery systems. Lectin histochemistry and lectin-based biosensors are useful to detect transformed tissues and biomarkers related to disease occurrence; antitumor lectins reported are promising for cancer therapy. Here, we address lectins from distinct sources with some biological effect and biotechnological potential in the diagnosis and therapeutic of diseases, highlighting many advances in this growing field.

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Antitumor effect of soybean lectin mediated through reactive oxygen species-dependent pathway

Cited by 63 publications

References 29 publications

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

Eutirucallin: A Lectin with Antitumor and Antimicrobial Properties

Mechanism of autophagic regulation in carcinogenesis and cancer therapeutics

Lectins, Interconnecting Proteins with Biotechnological/Pharmacological and Therapeutic Applications

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