Antitumoral effects of [6]-gingerol [(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone] in sarcoma 180 cells through cytogenetic mechanisms

Lima, Róbson Borges de; Reis, Antonielly Campinho dos; Santos, José Victor de Oliveira; Ferreira, José Roberto de Oliveira; Filho, José Williams Gomes de Oliveira; Dias, Ana Carolina Soares; Menezes, Ag-Anne Pereira Melo de; Mata, Ana M.; Alencar, Marcus Viní­cius Oliveira Barros de; Andrade, Teresinha de Jesus Aguiar dos Santos; Paz, Márcia Fernanda Correia Jardim; Rodrigues, Débora Caroline do Nascimento; Ferreira, Paulo Michel Pinheiro; Sousa, João Marcelo de Castro e; Mishra, Siddhartha; Islam, Muhammad Torequl; Melo‐Cavalcante, Ana Amélia de Carvalho

doi:10.1016/j.biopha.2020.110004

Cited by 16 publications

(6 citation statements)

References 84 publications

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“…Besides, 6-gingerol in low concentration is able to repair oxidative damage in normal cells. 177 Taken together, gingerol can reduce the progression of tumor cells and metastatic burden by DOXinduced apoptosis and ROS generation, which shows the ameliorative activity of gingerol against DOX toxicity (Figure 3). 177,178 Bleomycin Neoplastic diseases, such as testicular carcinoma, ovarian cancer, and malignant pleural effusions, are treated with various chemotherapeutic medicines.…”

Section: Drug-induced Toxicitymentioning

confidence: 91%

“…177 Taken together, gingerol can reduce the progression of tumor cells and metastatic burden by DOXinduced apoptosis and ROS generation, which shows the ameliorative activity of gingerol against DOX toxicity (Figure 3). 177,178 Bleomycin Neoplastic diseases, such as testicular carcinoma, ovarian cancer, and malignant pleural effusions, are treated with various chemotherapeutic medicines. Bleomycin, a member of chemotherapeutic agents, belongs to the glycopeptide group, which derives from the bacterium Streptomyces verticillus.…”

Section: Drug-induced Toxicitymentioning

confidence: 91%

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Promising effects of gingerol against toxins: A review article

et al. 2021

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Ginger is a medicinal and valuable culinary plant. Gingerols, as an active constituent in the fresh ginger rhizomes of Zingiber officinale, exhibit several promising pharmacological properties. This comprehensive literature review was performed to assess gingerol's protective and therapeutic efficacy against the various chemical, natural, and radiational stimuli. Another objective of this study was to investigate the mechanism of anti-inflammatory, antioxidant, and antiapoptotic properties of gingerol. It should be noted that the data were gathered from in vivo and in vitro experimental studies. Gingerols can exert their protective activity through different mechanisms and cell signaling pathways.For example, these are mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kB), Wnt/β-catenin, nuclear factor erythroid 2-related factor 2/antioxidant response element (Nrf2/ARE), transforming growth factor beta1/Smad3 (TGF-β1/Smad3

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Section: Drug-induced Toxicitymentioning

confidence: 91%

Section: Drug-induced Toxicitymentioning

confidence: 91%

Promising effects of gingerol against toxins: A review article

et al. 2021

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“…The anti-cancer potency of 6-Gingerol has been proven for many types of cancer cells including colorectal cancer, ovarian cancer, cervical cancer and retinoblastoma. In the experiments described in the literature, the most frequently used concentrations were in the range of 1-100 µM [23][24][25][26][27]. In our study, the minimum concentration of 6-Gingerol at which a statistically significant decrease in mitochondrial activity was observed was 25 µM.…”

Section: Discussionmentioning

confidence: 46%

Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma

et al. 2022

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Breast cancer is one of the most common malignant neoplasms, and despite the dynamic development of anticancer therapies, 5-year survival in the metastatic stage is still less than 30%. 6-Gingerol (1-[4′-hydroxy-3′-methoxyphenyl]-5-hydroxy-3-decanone) is a substance contained in ginger, which exhibits anti-cancer properties. Paclitaxel is a cytostatic substance used to treat breast cancer, but its therapeutically effective dose has many adverse effects. The aim of the presented study was to assess the anticancer effect of 6-gingerol and the possibility of increasing the effectiveness of Paclitaxel in the death induction of wild type human breast cancer cells. MCF-7/WT cells were treated with drugs—6-gingerol and paclitaxel at selected concentrations. The mitochondrial activity assay, caspase 7 activity assay, ATP assay, microscopy studies, and RT-PCR assays were performed to evaluate the antitumor activity and mechanism of action of both compounds, alone and in combination. After 72 h of incubation, the mitochondrial activity showed that the combination of 5 nM Paclitaxel with 10 µM 6-Gingerol led to the same decrease in viability as the use of 20 nM Paclitaxel alone; 10 µM 6-Gingerol led to an enhancement of caspase 7 activity, with the highest activity observed after 24 h of incubation. A real-time PCR study showed that 6-Gingerol induces the simultaneous transcription of Bax with TP53 genes in large excess to BCL-2. In contrast, 5 nM Paclitaxel induces TP53 transcription in excess of BCL-2 and Bax. Our results suggest that 6-Gingerol may act as a cell death-inducing agent in cancer cells and, in combination with paclitaxel, and increase the effectiveness of conventional chemotherapy.

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“…The action mechanisms attributed to gingerol include reduction of inflammation (decrease of NFκB and COX-2), induction of phase II detoxification enzymes (Nrf2), genomic instability (tubulin interactions), and altered gene expression (increased expression of pro-apoptotic molecules and decreased expression of anti-apoptotic factors), among others [140]. These effects have been corroborated in different in vitro cultures, such as neuroblastoma, sarcoma, human myeloid leukemia, breast Caco-2 cancer cells, and also in breast cancer-animal models [141][142][143][144][145]. Recently, studies have demonstrated that gingerol may be used in combination with cisplatin [146] or doxorubicin [145], to improve their efficacy.…”

Section: Gingerolmentioning

confidence: 87%

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

et al. 2021

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Nowadays, cancer is one of the deadliest diseases in the world, which has been estimated to cause 9.9 million deaths in 2020. Conventional treatments for cancer commonly involve mono-chemotherapy or a combination of radiotherapy and mono-chemotherapy. However, the negative side effects of these approaches have been extensively reported and have prompted the search of new therapeutic drugs. In this context, scientific community started to look for innovative sources of anticancer compounds in natural sources, including traditional plants. Currently, numerous studies have evaluated the anticancer properties of natural compounds derived from plants, both in vitro and in vivo. In pre-clinical stages, some promising compounds could be mentioned, such as the sulforaphane or different phenolic compounds. On the other hand, some phytochemicals obtained positive results in clinical stages and were further approved for cancer treatment, such as vinca alkaloids or the paclitaxel. Nevertheless, these compounds are not exempt of limitations, such as low solubility, restricted effect on their own, negative side-effects, etc. This review aims to compile the information about the current phytochemicals used for cancer treatment and also promising candidates, main action mechanisms and also reported limitations. In this sense, some strategies to face the limitations have been considered, such as nano-based formulations to improve solubility or chemical modification to reduce toxicity. In conclusion, although more research is still necessary to develop more efficient and safe phytochemical drugs, more of these compounds might be used in future cancer therapies.

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Antitumoral effects of [6]-gingerol [(S)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-decanone] in sarcoma 180 cells through cytogenetic mechanisms

Cited by 16 publications

References 84 publications

Promising effects of gingerol against toxins: A review article

Promising effects of gingerol against toxins: A review article

Anticancer Efficacy of 6-Gingerol with Paclitaxel against Wild Type of Human Breast Adenocarcinoma

Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment

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