Antityrosinase and antioxidant activities of guanidine compounds and effect of guanylthiourea on melanogenesis

Wang, Yuxia; Su, Wei‐Ming; Wang, Qin; Lin, Yu‐Feng; Zhou, Yuan; Lin, Long-Fang; Ren, Su; Li, Yanting; Chen, Qing‐Xi; Shi, Yan

doi:10.1016/j.procbio.2019.07.003

Cited by 14 publications

(4 citation statements)

References 46 publications

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“…S54 A, S54B , as the concentration of the effector from 0 µM to 60 µM, the maximum emission wavelength of ANS-TYR fluorescence shifted from 533 nm to 500 nm, resulting in a significant blue shift, and the fluorescence intensity continued to increase. The results showed that compound 6f could alter the enzyme's conformation, exposing the hydrophobic region that binds to ANS ( Wang et al, 2019 ).…”

Section: Resultsmentioning

confidence: 99%

Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors

He,

Zhang,

et al. 2024

Food Chemistry: X

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Section: Resultsmentioning

confidence: 99%

Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors

He,

Zhang,

et al. 2024

Food Chemistry: X

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“…Therefore, it is imperative to investigate the mechanism of 6 ′ -O-caffeoylarbutin-induced tyrosinase inhibition by comprehensively examining the conformational characteristics of the tyrosinase-6 ′ -O-caffeoylarbutin complex at the molecular level. Mushroom tyrosinase (mTyr) derived from Agaricus bisporus stands as a prominent and cost-effective source of active tyrosinase, serving as the exclusive commercially accessible variant [14]. Consequently, our study undertakes a comprehensive exploration to elucidate the potential mechanism of 6 ′ -O-caffeoylarbutin-induced mTyr activity inhibition.…”

Section: Introductionmentioning

confidence: 99%

6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor

Xie,

Fu,

Yuan

et al. 2024

IJMS

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Tyrosinase is vital in fruit and vegetable browning and melanin synthesis, crucial for food preservation and pharmaceuticals. We investigated 6′-O-caffeoylarbutin’s inhibition, safety, and preservation on tyrosinase. Using HPLC, we analyzed its effect on mushroom tyrosinase and confirmed reversible competitive inhibition. UV_vis and fluorescence spectroscopy revealed a stable complex formation with specific binding, causing enzyme conformational changes. Molecular docking and simulations highlighted strong binding, enabled by hydrogen bonds and hydrophobic interactions. Cellular tests showed growth reduction of A375 cells with mild HaCaT cell toxicity, indicating favorable safety. Animal experiments demonstrated slight toxicity within safe doses. Preservation trials on apple juice showcased 6′-O-caffeoylarbutin’s potential in reducing browning. In essence, this study reveals intricate mechanisms and applications of 6′-O-caffeoylarbutin as an effective tyrosinase inhibitor, emphasizing its importance in food preservation and pharmaceuticals. Our research enhances understanding in this field, laying a solid foundation for future exploration.

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“…The use of antioxidant compounds for the treatment of hyperpigmentation based on the fact that interruption of the production of malanin occurs through tyrosine oxireduction has been shown to be effective in some studies 29–31 …”

Section: Introductionmentioning

confidence: 99%

“…27,28 The use of antioxidant compounds for the treatment of hyperpigmentation based on the fact that interruption of the production of malanin occurs through tyrosine oxireduction has been shown to be effective in some studies. [29][30][31] In this regard, cysteamine has been proposed as a depigmenting agent under the use of topical formulations in the treatment of skin hyperpigmentations such as melasma. 32,33 Cysteamine is an aminothiol derived from the coenzyme A degradation pathway 34 and synthesized in diverse cell types.…”

Section: Introductionmentioning

confidence: 99%

Is cysteamine use effective in the treatment of melasma? A systematic review and meta‐analysis

Neto

Silva

Melo

et al. 2022

Dermatologic Therapy

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Melasma is a recurrent hypermelanosis disorder characterized by the appearance of brownish and symmetrical spots on the skin. It affects the quality of life and is resistant to available treatment approaches. Cysteamine has been reported as a promising depigmenting agent for melasma treatment and following formulation enhancement, its use is being reported. This review aimed to evaluate the efficacy of the use of depigmenting formulations containing 5% cysteamine in the treatment of patients with melasma. A systematic search was performed in PubMed, Science Direct, and Scielo databases until December 27, 2021, based on criteria selected by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Statistical analysis was performed with Review Manager 5.4 software. The risk of bias was assessed using the Cochrane Risk of Bias Tool for Randomized Trials. A total of six studies containing 120 melasma patients treated with 5% cysteamine were included in this metaanalysis. The meta-analysis demonstrated that 5% cysteamine is effective for the treatment of patients with melasma , p < 0.0001, I 2 = 86%).In this review, through meta-analysis allows concluding that 5% cysteamine is effective in the treatment of melasma and presents a low probability of side or adverse effects.

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Antityrosinase and antioxidant activities of guanidine compounds and effect of guanylthiourea on melanogenesis

Cited by 14 publications

References 46 publications

Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors

Synthesis, anti-browning effect and mechanism research of kojic acid-coumarin derivatives as anti-tyrosinase inhibitors

6′-O-Caffeoylarbutin from Quezui Tea: A Highly Effective and Safe Tyrosinase Inhibitor

Is cysteamine use effective in the treatment of melasma? A systematic review and meta‐analysis

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