Antiulcer activity of Amlapitta Mishran suspension in rats: A pilot study

Abstract

Context:Amlapitta Mishran suspension is a poly herbal ayurvedic formulation, which has been traditionally used for acidity and gastric ulcers.Aim:The aim of this study is to evaluate the antiulcer activity of Amlapitta Mishran on non-steroidal anti-inflammatory drugs (NSAID's) -induced ulcers in the rat model.Subjects and Methods:The antiulcer activity of Amlapitta Mishran was investigated on indomethacin (100 mg/kg) NSAID's induced ulcers in rats. Effect of two different doses of Amlapitta Mishran was studied by calculating the total number of ulcers, ulcer index and percentage inhibition.Statistical Analysis Used:Data was analyzed by the Student's t-test (P < 0.05).Results:Amlapitta Mishran treated rats have shown significant (P < 0.0001) decrease in the total number of ulcers and ulcer index and significant increase in % inhibition of ulcers as compared with positive control group.Conclusion:The results indicate that Amlapitta Mishran has showed a dose dependent antiulcer activity in experimental animals and confirms ayurvedic use of Amlapitta Mishran in gastric ulcers.

The Protective Effect of Aged Garlic Extract on Nonsteroidal Anti‐Inflammatory Drug‐Induced Gastric Inflammations in Male Albino Rats

“…It works by inhibiting the production of prostaglandins, which normally protect the gastrointestinal mucosa from damage by maintaining blood flow and increasing mucosal secretion of mucous and bicarbonate [ 14 ]. Indomethacin has been shown to produce sever gastric damage in rats than did others and has become the preferred drug for inducing ulcer models [ 11 , 12 , 15 ]. The increased levels of reactive oxygen species (ROS) reported in the mechanism of both stress and IN-induced gastric damage [ 16 ].…”

A prospective, single centre, open label, single arm pilot study to evaluate the efficacy and safety of Amlapitta Mishran Suspension in participants with endoscopic gastritis

“…Amlapitta Mishran Suspension is documented for its anti-ulcer effect in an experimental model of indomethacin-induced gastric ulcers in rats [ 5 ]. It has multiple ingredients with different actions that act in synergy and these ingredients possess anti-emetic, anti-ulcer, anti-secretory, gastroprotective, and acid-neutralizing properties [ [6] , [7] , [8] , [9] , [10] , [11] , [12] , [13] , [14] , [15] , [16] , [17] , [18] ].…”