The Protective Effect of Aged Garlic Extract on Nonsteroidal Anti‐Inflammatory Drug‐Induced Gastric Inflammations in Male Albino Rats

Abstract

Natural products have long gained wide acceptance among the public and scientific community in the gastrointestinal ulcerative field. The present study explore the potential effects of aged garlic extract (AGE) on indomethacin-(IN-) induced gastric inflammation in male rats. Animals were divided into six groups (n = 8) control group, IN-induced gastric inflammation group via oral single dose (30 mg/kg to fasted rats) two AGE orally administered groups (100 and 200 mg/kg for 30 consecutive days) two AGE orally administered groups to rats pretreated with IN at the same aforementioned doses. The results declared the more potent effect of the higher AGE dose (200 mg/kg) as compared to that of the 100 mg/kg dose in the gastroprotective effects reflected by significant gastric mucosal healing of damage and reduction in the total microbial induced due to indomethacin administration. In addition to the significant effect to normalize the significant increase in malondialdehyde (MDA), myeloperoxidase (MPO), tumor necrosis factor-α (TNF-α) values, and the significant decrease in the total glutathione (tGSH), superoxide dismutase (SOD), and catalase (CAT) values induced by indomethacin. The results support AGE antioxidant, anti-inflammatory, and antimicrobial potency reflected by the healing of the gastric tissue damage induced by indomethacin.

Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

“…SOD plays an important role in preventing gastric ulcer by catalyzing the breakdown of highly reactive radical superoxide (O 2-) into oxygen and hydrogen peroxide [79,80]. In agreement with the report of [81,15] the inhibition of the antioxidant enzymes, SOD and GST following SGU in the present study may be due to the enhancement of the lipid peroxidation which, inhibit protein synthesis and consequently the activities of certain enzymes. In contrary, IND and cold stress induced a significant increase in the CAT activity in the gastric and duodenal tissues.…”

Antiinflammatory Effects of Functionally Active Compounds Isolated from Aged Black Garlic

“…Previous research has shown the immunotherapeutic potential of whole garlic extract, including its antiinflammatory, anticancer, and anti‐angiogenic effects. It has been shown to improve hyperglycemia and dyslipidemia, cardiovascular diseases, infectious diseases, autoimmune diseases, and allergies in various physiological tissues (Badr and Al‐Mulhim, ; Yin et al ., ; G et al ., ; Chandrashekar and Venkatesh, ). It is known that aqueous garlic extract is an antioxidant by scavenging reactive oxygen species and enhancing cellular antioxidant enzymes (superoxide dismutase, catalase, and glutathione peroxidase).…”

Allium sativum

“…DADS effectively suppressed the production of proinfl ammatory mediators induced by ethanol and prevented the formation of gastric malondialdehyde and the depletion of reduced glutathione content and restored antioxidant enzyme activities, such as catalase, glutathione peroxidase and glutathione reductase in the gastric tissues of ethanol-treated rats. Aged garlic extract (AGE) especially at 200 mg/kg protected against indomethacin (IN)-induced gastric infl ammation in male rats as refl ected by signifi cant gastric mucosal healing of damage and reduction in the total microbial induced due to indomethacin administration (Badr and Al-Mulhim 2014 ). Further AGE normalised the signifi cant increase in malondialdehyde (MDA), myeloperoxidase (MPO), tumour necrosis factor-α (TNF-α) values and the signifi cant decrease in the total glutathione (tGSH), superoxide dismutase (SOD) and catalase (CAT) values induced by indomethacin.…”