Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Sayed, Dawlat A; Fahmy, Sohair R.; Soliman, Amel M.; Hussein, Nagat S.

doi:10.22159/ijpps.2016v8i9.12846

Cited by 12 publications

(10 citation statements)

References 72 publications

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“…Natural products were considered as a rich source of compounds for drug discovery [25]. Therefore, by scavenging free radicals, antioxidants from plant sources may play an important role in gastric ulcer therapy [26]. In accordance with this report, methanolic extract showed the highest scavenging capacity for 2,2-diphenyl-1-picrylhydrazyl radical, superoxide radical scavenging activity recorded in our study [14].…”

Section: Resultssupporting

confidence: 88%

Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Rameshwari¹,

Ayshwarya²

2017

Asian J Pharm Clin Res

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Objective: To investigate the antiulcerogenic activity of methanolic extract of Brassica var. capitata rubra in albino rats. Methods:To evaluate the antiulcer activity by pyloric ligation models experimentally induced gastric ulcer by ranitidine (10 mg/kg) subcutaneously. The parameters taken to assess antiulcer activity were free acidity, total acidity, volume of gastric juice, PH, ulcer score, and ulcer index. Results:The methanolic extract of Brassica oleracea var. capitata rubra in the dose of 0.50 mg/kg produced significant antiulcer activity. The control animals had ulcers and hemorrhagic streaks, whereas in animals administered with extracts of B. oleracea there was a significant reduction in ulcer index (p˂0.05). Conclusion:This study concluded that methanol extract of B. oleracea var. capitata has healing property of gastric ulcers in albino rats.

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Section: Resultssupporting

confidence: 88%

Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Rameshwari¹,

Ayshwarya²

2017

Asian J Pharm Clin Res

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“…The results suggested that a high dose of CB (3000 mg/kg) could be better in activating antioxidant factors than omeprazole was. As the terminal product of lipid peroxidation, MDA is introduced to indicate its level [ 42 , 43 ]. The level of MDA increased in indomethacin-induced gastric mucosal lesions.…”

Section: Discussionmentioning

confidence: 99%

Effect of Cuttlebone on Healing of Indomethacin‐Induced Acute Gastric Mucosal Lesions in Rats

Qiu

Yao

Fang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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The continuing use of nonsteroidal anti-inflammatory drugs (NSAIDs) usually increases the side effects such as peptic ulcer and acute gastric lesions in the gastrointestinal tract. Cuttlebone (CB), isolated from Sepiella maindroni de Rochebrune, was reported to have antioxidant activities, but its role in the treatment of indomethacin-induced gastric lesions has not yet been confirmed. In this research, we investigate the protective effect of cuttlebone on indomethacin-related ulcers in rats and possible mechanisms. Here, gastric ulcers were induced by oral administration of indomethacin, and then the rats were treated with omeprazole (4 mg/kg) or different doses (750, 1500, and 3000 mg/kg of body weight) of cuttlebone. We evaluated lesion index, inflammation score, and a series of oxidant/antioxidant parameters. The data demonstrated that cuttlebone could protect against gastric ulcers induced by indomethacin in a dose-dependent manner (positive correlation). Also, these effects were associated with attenuating the expression of malonaldehyde (MDA) and increasing the levels of some protective ingredients like epidermal growth factor (EGF), prostaglandin E2 (PGE2), and superoxide dismutase (SOD). Thus, considering its ability to protect indomethacin-induced acute gastric mucosal lesions and the underlying mechanisms, CB might be a potential candidate for treating gastric damage caused by NSAIDs.

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“…The mucosal damage areas were expressed as a percentage of the total surface area of the glandular stomach estimated in square millimeters. The mean ulceration score for every animal was expressed as an ulceration index, and also the percentage inhibition against ulceration was determined using the expression as follows [7].…”

Section: Evaluation Of Ulcerationmentioning

confidence: 99%

ANTIULCER ACTIVITY OF ELECTROHOMEOPATHIC DRUG (SPAGYRIC ESSENCE) CANCEROUS 15 - 3rd DILUTION AGAINST INDOMETHACIN-INDUCED GASTRIC ULCER IN RATS

Sabat

2019

Asian J Pharm Clin Res

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Objective: To evaluate the curative protects activity of electrohomeopathic drug Cancerous15 (C15) against Indomethacin (IND)-induced gastric ulcer in albino rats. None of the data have been reported on antiulcer activity of C15 drug. Hence, the present study focuses on the scientific investigation of antiulcer activity of C15 against Indomethacin-induced peptic ulceration of rat models. Methods: A total number of 35 albino rats were divided into five groups equally. Pure water was given to Group 1 (normal). IND was given orally to Group 2 (ulcerated control). Cancerous15 third dilution was given to Group 3. IND was given to Group 4 and Group 5 animals, thereafter pretreatment with Esomeprazole (ESM) and C15-third dilution, respectively. The pretreatments were treated in each day’s interval for 21 days before IND administration. There was provision of food and water throughout the experimental period. On the 23rd day, the stomachs of the sacrificed rats were removed, and (1) ulcer index, (2) percentage of ulcer inhibition, (3) gastric volume, (4) pH, (5) pepsin activity, (6) mucin content, (7) malondialdehyde (MDA) concentration, and (8) stearidonic acid activity were studied. Results: The pre-treated animals with ESM and C15 shown as significantly decreases in ulcer index, gastric volume, pepsin activity and MDA concentration, and significant increase in the percentage ulcer inhibition, pH value, mucin content, and superoxide dismutase activity concentration in comparison to ulcer-induced rats. Conclusion: The study shows the significant ulcer protective activity of the C15 drug against IND-induced peptic ulceration in rats.

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Antiulcerogenic Efficacy of Ethanolic Extract of Vitis Vinifera Leaves in Rats

Cited by 12 publications

References 72 publications

Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Effect of Cuttlebone on Healing of Indomethacin‐Induced Acute Gastric Mucosal Lesions in Rats

ANTIULCER ACTIVITY OF ELECTROHOMEOPATHIC DRUG (SPAGYRIC ESSENCE) CANCEROUS 15 - 3rd DILUTION AGAINST INDOMETHACIN-INDUCED GASTRIC ULCER IN RATS

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