Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Rameshwari, K. Sudha; Ayshwarya, M

doi:10.22159/ajpcr.2017.v10i3.16217

Cited by 7 publications

(3 citation statements)

References 21 publications

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“…So, it was almost comparable to that of a standard drug. Our results, similar to the antiulcer activity of methanol extract of B. oleracea in pylorus ligation model was evident from its significant reduction in gastric volume, total acidity, free acidity, ulcer index, and increase in pH of gastric juice 18 . The excess gastric formation of prostaglandin was increased in mucosal resistance as well as a decrease in aggressive factors, mainly acid and pepsin.…”

Section: Anti-bacterial Activity: Various Extracts Ofsupporting

confidence: 89%

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2021

IJPSR

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The present study deals with the phytochemical analysis and evaluation of antibacterial activity of hydroalcohol, acetone, and hexane extracts of the leaves of Psidium guajava. The antimicrobial activity was measured by the agar well diffusion method. Gastric volume, pH, total and free acidity and the ulcerative index was also measured in hydroalcoholic extract of Psidium guajava on gastric ulcer pyloric ligation in rat. Glycosides, terpenoids, and tannins are only present in the hydro alcohol extract. The extracts are tested against gram-negative (Escherichia coli) and gram-positive (Staphylococcus aureus, Bacillus subtilis) bacterial strains. The zone of inhibition against microorganisms is direct proportional to the concentration of extract. Maximum zone of inhibition (24mm) against Staphylococcus aureus except hexane extract was seen. Psidium guajava leaves show maximum phytochemicals compounds and inhibition of microorganisms in hydroalcoholic extract. So the hydroalcoholic extraction was used for anti-ulcer activity. The present study was performed in pylorus ligation induced gastric ulcer model in albino rats in which the ability of hydroalcoholic extracts of Psidium guajava was tested at a dose level of 400 mg/kg body weight orally and compared with Ranitidine (10 mg/kg) as standard. From the results it is concluded hydro alcohol leaf extracts of Psidium guajava 400 mg/kg dose level showed significant anti-ulcer activity when compared to that of standard drug. INTRODUCTION:Ulcer can be developed inside the inner lining of the stomach (gastric ulcer) or the small intestine (duodenal ulcer). Both the ulcers are also cumulatively referred to as peptic ulcers. It affects nearly 10% of the world population 1 .

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Section: Anti-bacterial Activity: Various Extracts Ofsupporting

confidence: 89%

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2021

IJPSR

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“…The indole-3-carbinol, a phytochemical compound found in the cauliflower, possessed anti-ulcer activity alone or combination with omeprazole on aspirin-induced gastric ulcer in male albino rats [58]. The methanolic extract of Brassica oleracea also reduced ulcer index (p<0.05) in the dose 0.50 mg/kg [59].…”

Section: Cauliflowermentioning

confidence: 98%

Anti-Ulcer Agents: A Pharmacological Update of the Past Ten Years

Mandal¹,

Dawn²,

Bose

2019

Asian J Pharm Clin Res

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New anti-ulcer substances are still vitally necessary for the people of countries such as India and South Africa to avoid high cost of the most prescribed marketed anti-ulcer drugs (proton-pump inhibitors). New candidate against gastric ulcer is also necessary to avoid the potential problem (enterochromaffin-like cell hyperplasia may be induced) associated with the long-term use of synthetic proton-pump inhibitors. However, the search for the novel entity against ulceration is challenging because of the complexity of the ulcer process and its role in host defense to infections. Nature is the source of remedies for the humankind. Among the different biological activities of the natural products that have been published till date, anti-ulcer is one of the most reported effects. Some single natural products such as curcumin, 1-hydroxy-3,7,8-trimethoxyxanthone, cinnamic acid, thymol, epoxycarvone, and menthol; single synthetic products such as, 4,6-diaryl-3, 4-dihydropyrimidin-2(1H)-thiones, 1,4-dihydropyrimidine derivatives, and dihydropyrimidinone and piperidine hybrids; plant products such as Aloe vera, Mangifera indica, Zingiber officinale, Azadirachta indica, Psidium guava, Carica papaya, Panax ginseng, Terminalia chebula, Ocimum sanctum, Daucus carota, and Mimosa pudica, Alpinia galangal; nutraceuticals such as garlic, cauliflower, banana, honey, cucumber, and cod liver oil with anti-ulcer effects have been discussed in this review. A complete review of literature was conducted using different databases on ScienceDirect, Scopus, PubMed, and Google Scholar. This review is a genuine attempt to explore the past 10 years’ pharmacological update of some anti-ulcer agents.

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“…Based on earlier reports, secondary metabolites found in plants are phenols and terpenoids, which represent the primary antimicrobial reagent (Jayanthi et al, 2011). Flavonoids show anti-allergic, antiin lammatory, antimicrobial, and anti-cancer activity (Rameshwari and Ayshwarya, 2016;Yamato, 2002).…”

Section: Antimicrobial Activitymentioning

confidence: 99%

Synthesis And Evaluation Of Herbal Formulation Using Natural Extract

Rameshwari¹,

M²,

R³

et al. 2020

ijrps

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Our study is intended to prepare and evaluate the polyherbal formulation (PHF) using Nyctanthes arbor-tristis, Piper nigrum, and lemon juice. Poly Herbal Formulation F1 and F2 were synthesised and subjected to qualitative, quantitative phytochemical analysis and antioxidant activity was measured using a standard protocol. Antimicrobial activity of PHFs was observed by the agar well diffusion method. The anti-inflammatory and anti-diabetic activities (In-vitro) were studied in F1 by using inhibition of albumin denaturation method. TLC and FTIR are done for the structural elucidation in F1. The F1 and F2 exhibited the presence of flavonoids, alkaloids, tannins, phenols, terpenoids, carbohydrates, saponins, Glycosides and proteins. The F1 and F2 show significant activity against the standard in the antimicrobial and antioxidant activity. The presence of flavonoids and alkaloids may contribute to the anti-microbial activity. The Nitric oxide radical scavenging activity and a metal chelating assay of the F1 possess the highest antioxidant activity of 73.1% and 69% respectively. TLC confirms the presence of flavonoids in F1. FTIR spectrum shows the functional group of amines, alcohols, nitrites, aromatic and aliphatic compounds. These FTIR bands denote stretching and vibrational bands responsible for the compounds like flavonoids, terpenoids, phenols and amino acids. This investigation shows the excellent result in antimicrobial, antioxidant and in-vitro anti-diabetic and anti-inflammatory activities. In future, the PHF of F1 can be used as potent therapeutical agents and can be further exploited for their other beneficial effect in the pharmacological studies.

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Evaluation of Antiulcerogenic Activity of Methanol Extracts of Brassica Oleracea Var. Capitata Rubra on Albino Rat Gastric Ulceration

Cited by 7 publications

References 21 publications

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Anti-Ulcer Agents: A Pharmacological Update of the Past Ten Years

Synthesis And Evaluation Of Herbal Formulation Using Natural Extract

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