Antiulcer effects of amylin: a review

Samonina, G. E.; Kopylova, G. N.; Lukjanzeva, G.V; Zhuykova, S.E; Смирнова, Е. А.; German, S. V.; Гусева, А. А.

doi:10.1016/j.pathophys.2003.10.008

Cited by 34 publications

(16 citation statements)

References 53 publications

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“…It is known that intragastric instillation of ethanol results in gastric mucosa injury characterized by disturbances in microcirculation, mast cell secretory products, inhibition of prostaglandin synthesis, reduction in mucus production and reactive oxygen species (Samonina et al, 2004).…”

Section: Absolute Ethanol-induced Gastric Lesionsmentioning

confidence: 99%

Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models

Freitas

Fernandes

Piauilino

et al. 2011

Journal of Ethnopharmacology

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Our results indicate that the ethanolic extract of Zanthoxylum rhoifolium exhibits a significant gastroprotection, because it inhibits the formation of gastric lesions using different models. The release of the nitric oxide, the opening of the K(ATP) channels, the participation of the non-protein sulfhydril groups (NP-SH), catalase and the increase of mucous secretion seem to be involved in the gastroprotection activity of the EEZR. Nevertheless, this activity does not seem to be related to antisecretory mechanisms.

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Section: Absolute Ethanol-induced Gastric Lesionsmentioning

confidence: 99%

Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models

Freitas

Fernandes

Piauilino

et al. 2011

Journal of Ethnopharmacology

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“…Ethanol-induced damages are induced by disturbance of mucosal microcirculation, ischaemia and appearance of free radicals, endotelin release, degranulation of mast cells, inhibition of prostaglandins and decrease of mucus production (Samonina et al, 2004). The best inhibitory effect on the ulcerative index was observed with oral treatment of HAE showing a decrease of 81% (1000 mg/kg), 88% (500 mg/kg) and 84% (250 mg/kg), respectively, when compared to the ulcerative index of 141 ± 12.52 of the control group ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: Role of endogenous sulphydryls and nitric oxide

Kushima

Hiruma-Lima

Santos

et al. 2005

Journal of Ethnopharmacology

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“…We thus evaluated the action of EOHM on oxidative stress caused by ethanol-induced gastric damage in rats, to show possible antioxidant activity. Ethanol destroys cells by causing mucosal disturbances in the microcirculation of free radicals in the mucosa, increased lipid peroxidation, a decrease of non-protein sulfhydryl groups (GSH) and mucus production and inhibition of gastric prostaglandins [30]. Furthermore, ethanol also destroys epithelial cells in the stomach, causing infiltration of inflammatory cells such as neutrophils and macrophages, which eventually produce vasoconstriction, submucosal edema and hemorrhagic lesions [31].…”

Section: Discussionmentioning

confidence: 99%

Gastroprotective and Ulcer Healing Effects of Essential Oil of Hyptis martiusii Benth. (Lamiaceae)

et al. 2014

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Hyptis martiusii Benth. is an aromatic plant found in abundance in northeastern Brazil that is used in ethnomedicine to treat gastric disorders. The aim of this study was to elucidate the mechanisms of action involved in the gastroprotection of the essential oil of Hyptis martiusii (EOHM) and to evaluate its healing capacity. Wistar rats were exposed to different protocols and subsequently were treated with 1% Tween-80 aqueous solution (negative control), pantoprazole, carbenoxolone, N-acetylcysteine (depending on the specificity of each model) or EOHM. The antisecretory activity (basal or stimulated) was determined using the pyloric ligature method. The gastroprotective action of nitric oxide and sulphydryl groups (–SH groups), as well as the quantification of adherent mucus and the levels of malondialdehyde and –SH groups in gastric mucosa, were evaluated using ethanol-induced gastric ulcer model. The healing ability was evaluated using the acetic acid-induced gastric ulcer model and histological and immunohistochemical analysis (HE, PAS and PCNA). EOHM (400 mg/kg) reduced the volume and acidity of gastric secretion stimulated by histamine and pentagastrin. The gastroprotective effect of EOHM involves the participation of endogenous sulfhydryl groups. EOHM increased mucus production (54.8%), reduced levels of MDA (72.5%) and prevented the depletion of –SH groups (73.8%) in the gastric mucosa. The treatment with EOHM reduced in 70.3% the gastric lesion area, promoting significant regeneration of the gastric mucosa, as confirmed by histological analysis and analysis of proliferating cell nuclear antigen. The results show that gastroprotective effect of EOHM is mediated by cytoprotective and antioxidant mechanisms and by their antisecretory activity, and suggest that the essential oil of Hyptis martiusii is a promising candidate for the treatment of gastric ulcers.

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Antiulcer effects of amylin: a review

Cited by 34 publications

References 53 publications

Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models

Gastroprotective activity of Zanthoxylum rhoifolium Lam. in animal models

Gastroprotective activity of Pradosia huberi on experimentally induced gastric lesions in rodents: Role of endogenous sulphydryls and nitric oxide

Gastroprotective and Ulcer Healing Effects of Essential Oil of Hyptis martiusii Benth. (Lamiaceae)

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