Antiulcer potential of Rubia cordifolia Linn. in experimental animals

Kalra, Pankaj; Sharma, Sunil; Datusalia, Ashok Kumar

doi:10.4103/0973-8258.85182

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The gastroprotective effect were evaluated by examining free and total acidity and pepsin concentration. 35,36 The gross morphologic changes were recorded by examining photomicrographs of gastric mucosa and the degree of ulceration were graded according to previous reported ulcer scoring method. 37…”

Section: Gastro-protective Activitymentioning

confidence: 99%

Bio-oriented synthesis of ibuprofen derivatives for enhancement efficacy in post-operative and chronic inflammatory pain models

et al. 2023

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Section: Gastro-protective Activitymentioning

confidence: 99%

Bio-oriented synthesis of ibuprofen derivatives for enhancement efficacy in post-operative and chronic inflammatory pain models

et al. 2023

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“…Anti-ulcer activity: alcoholic extracts of roots of R. cordifolia and its antiulcer potential on alcohol, ibuprofen, coldrestraint stress and pyloric ligationinduced gastric lesions was studied along with ranitidine, a standard drug. 29 43,44 Manjishtha is a strong bitter in taste which is one of the major property for Pittahara. Pitta is responsible for the ulcers formation.…”

Section: Wound Healing Activitymentioning

confidence: 99%

Exploration in Pharmacological Screening of Rubia Cordifolia Verses Ayurvedic Documentation: A Comparative Validation

Khemji¹,

Vithal²,

Hiteshbhai³

2015

J Pharm Sci Innov

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Manjishtha is one of the most clinically practiced herbs in Ayurveda System of Medicine. It is also immensely documented in Ayurvedic traditional literature for various diseases. Out of its entire therapeutic spectrum, herb is famous for its activity on various skin diseases/blood disorders. The Latin name of Manjishtha is Rubia cordifolia Linn (Family: Rubiaceae) and is commonly sold under the trade name 'Majith' in Indian Market. In recent period many experiments were carried out in different field like Pharmacognosy, Pharmacology, Chemistry, etc to trace out valuable components from this plant. Being one of the major herbs in Ayurveda, it has attracted many researchers to explore its potential in Pharmacological field. It is observed that most of the screened Pharmacological results were seemed to be already documented in Ayurveda directly or indirectly since centuries. This documentation is mostly in the form of Sanskrit Sutra and carries large concealed information for those who understand the conceptual depth of Ayurveda. Here is a review of screened information verses Ayurvedic literature which is validating the claims made by the ancient sages.

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“…Lastly, volume was adjusted with distilled water up to 10 mL and protein absorbency was measured with ultraviolet visible (UV/VIS) spectrophotometer at 700 nm wavelength. Activity was expressed in terms of micro moles of tyrosine/ml or mg/dl bovine serum albumin (Kalra et al, 2011).…”

Section: Biochemical Gastric Juice Analysismentioning

confidence: 99%

Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates

Ali

Subhan

Islam

et al. 2013

Naunyn-Schmiedeberg's Arch Pharmacol

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The present study was conducted to synthesize nitrogen containing derivatives of salicyl alcohol and to investigate in vivo their ulcerogenic potential in comparison with aspirin in rats. The compounds [4-(2-hydroxybenzyl) morpholin-4-iumchloride (I)] and [1,4-bis(2-hydroxybenzyl) piperazine-1,4-diium chloride (II)] were synthesized and their chemical structures were characterized using spectral data. In our previous study (Ali et al., Afr J Pharm Pharmacol 7:585-596, 2013), both compounds showed anti-inflammatory, antinociceptive, and antipyretic properties in standard animal models and a greater binding affinity for cyclooxygenase-2 versus cyclooxygenase-1 in molecular docking and dynamics analysis. For in vivo studies, animals were randomly divided into four groups. The synthetic compounds (both at 100 or 150 mg/kg), aspirin (150 mg/kg), or saline vehicle was administered orally, once daily for 6 days and then tested for ulcerogenic activity. At the end of the procedure, gastric juice and tissues were collected and subjected to biochemical and histological analyses. The results of the study revealed that in the case of the aspirin-treated group, there was a significant increase in gastric juice volume, free acidity, total acidity, and ulcer score and a decrease in gastric pH. Moreover, histological examination of the gastric mucosa of the aspirin-treated group indicated morphological changes while neither of the synthetic compounds showed any significant ulcerogenic or cytotoxic properties. The results of the present study suggest that both compounds are free from ulcerogenic side effects and may represent a better alternative to aspirin.

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Antiulcer potential of Rubia cordifolia Linn. in experimental animals

Cited by 5 publications

References 16 publications

Bio-oriented synthesis of ibuprofen derivatives for enhancement efficacy in post-operative and chronic inflammatory pain models

Bio-oriented synthesis of ibuprofen derivatives for enhancement efficacy in post-operative and chronic inflammatory pain models

Exploration in Pharmacological Screening of Rubia Cordifolia Verses Ayurvedic Documentation: A Comparative Validation

Synthetically modified bioisosteres of salicyl alcohol and their gastroulcerogenic assessment versus aspirin: biochemical and histological correlates

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