Antiulcerogenic activity of Indigofera truxillensis Kunth

Cola-Miranda, Maira; Barbastefano, Víctor; Hiruma-Lima, Clélia Akiko; Calvo, Tamara Regina; Vilegas, Wagner; Brito, Alba Regina Monteiro Souza

doi:10.1590/s1676-06032006000300004

Cited by 15 publications

(14 citation statements)

References 31 publications

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“…Ethanol and aspirin-induced gastric ulcer models have been widely used for the evaluation of gastroprotective activity. Acute treatment with ethanol increases oxidative stress, DNA damage, xanthine oxidase activity and malondialdehyde levels, and decreases the total glutathione content in gastric mucosal cells 18 . Aspirin-induced ulcer is mediated through tissue damaging free radicals which are produced from the conversion of hydroperoxyl to hydroxy fatty acids, which leads to cell destruction 19 .…”

Section: Discussionmentioning

confidence: 96%

Evaluation of Antiulcer Activity of Wedelia Calendulacea Aqueous Extract in Rodents

Gindi¹,

Nagiat²,

Rao³

et al. 2013

J Pharm Sci Innov

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The present study was focused to evaluate the protective activity of the Wedelia calendulacea (WC) whole plant aqueous extract against aspirin-pylorus ligation, HCl-ethanol and water immersion stress induced ulcers. In the present study aspirin-pylorus ligation induced gastric ulcer was adopted to screen the antisecretory activity of plant extract. WC extract produced 61.76% ulcer inhibition at 400mg/kg body weight, when compared to that of standard (ranitidine, 50mg/kg) which produced 62.6% ulcer inhibition. In HCl-ethanol induced ulcer model 400mg/kg body weight of WC produced 88.87% ulcer inhibition when compared that of standard (sucralfate, 100mg/kg) which produced 90.80% ulcer inhibition. In water immersion-stress induced ulcer model 400mg/kg body weight of WC, produced 96.34% ulcer inhibition when compared to that of standard (omeprazole, 20mg/kg) which produced 99.30% ulcer inhibition. WC showed significant percentage of ulcer inhibition in the three models tested. The glycosides which are present in the aqueous extract could be responsible for their antiulcer properties.

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Section: Discussionmentioning

confidence: 96%

Evaluation of Antiulcer Activity of Wedelia Calendulacea Aqueous Extract in Rodents

Gindi¹,

Nagiat²,

Rao³

et al. 2013

J Pharm Sci Innov

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“…Peptic ulcer disease is a chronic inflammatory disease characterized by ulceration in the upper gastro-intestinal tract [23] . The pathophysiology of ulcers is due to an imbalance between aggressive factors (acid, pepsin, H. pylori and NSAIDs) and local mucosal defensive factors (mucus bicarbonate, blood flow and prostaglandins).…”

Section: Discussionmentioning

confidence: 99%

Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

Londonkar

Poddar²

2009

WJGO

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AIM:To examine the antiulcerogenic effects of various extracts of Mentha arvensis Linn on acid, ethanol and pylorus ligated ulcer models in rats and mice. METHODS:Various crude extracts of petroleum ether, chloroform, or aqueous at a dose of 2 g/kg po did not produce any signs or symptoms of toxicity in treated animals. In the pyloric ligation model oral administration of different extracts such as petroleum ether, chloroform and aqueous at 375 mg/kg po , standard drug ranitidine 60 mg/kg po and control group 1% Tween 80, 5 mL/kg po to separate groups of Wister rats of either sex (n = 6) was performed. Total acidity, ulcer number, scoring, incidence, area, and ulcer index were assessed. RESULTS:There was a decrease in gastric secretion and ulcer index among the treated groups i.e. petroleum ether (53.4%), chloroform (59.2%), aqueous (67.0%) and in standard drug (68.7%) when compared to the negative control. In the 0.6 mol/L HCl induced ulcer model in rats (n = 6) there was a reduction in ulcerative score in animals receiving petroleum ether (50.5%), chloroform (57.4%), aqueous (67.5%) and standard. drug (71.2%) when compared to the negative control. In the case of the 90% ethanol-induced ulceration model (n = 6) in mice, there was a decrease in ulcer score in test groups of petroleum ether (53.11%), chloroform (62.9%), aqueous (65.4%) and standard drug ranitidine (69.7%) when compared to the negative control. It was found that pre-treatment with various extracts of Mentha arvensis Linn in three rat/mice ulcer models ie ibuprofen plus pyloric ligation, 0.6 mol/L HCl and 90% ethanol produced significant action against acid secretion (49.3 ± 0.49 vs 12.0 ± 0.57, P < 0.001). Pre-treatment with various extracts of Mentha arvensisLinn showed highly -significant activity against gastric ulcers (37.1 ± 0.87 vs 12.0 ± 0.57, P < 0.001). CONCLUSION:

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“…Other compounds like saponins, quinines, tannins, garlic acid, caffeic acid, myricetin, quercetin myricetin and galangin were also reported [7]. The chemical constituents like kaempferitrin [8], louisfieserone, indigotin [9], (S) indispicine [10], benzofuran, dibenzofuran [11], arabinofuranoside [12], 12-oleanen-3, 11-dione, afromosin, genistein, isoliquiritigenin [13], rutin [14] endecaphyllin A1 and hiptagin [15], have been isolated and reported from various species of genus Indigofera. Keeping in view the above medicinal importance of this genus the medicinal plant I. heterantha was selected for phytochemical and pharmacological investigation.…”

Section: Introductionmentioning

confidence: 99%

Isolation and Biological Activity of β-Sitosterol and Stigmasterol from the Roots of Indigofera heterantha

Zeb¹,

Khan²,

Rahman³

et al. 2017

PPIJ

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In the ongoing phytochemical studies the roots of Medicinal plant known as Indigofera heterantha were investigated phytochemicaly in order to explore its medicinal potential. The ethyl acetate fraction was subjected to column chromatography which resulted in the isolation and purification of two new source compounds known as β-sitosterol (1) and Stigmasterol (2). The structures of these compounds were established by using Mass Spectrometry. The structures of these compounds were further authenticated by comparison with the literature data. The isolated pure compounds were screened for antidiabetic and membrane stabilizing activities. The antidiabetic activity of β-sitosterol (1) was measured on the basis of the glucose uptake in yeast cells. The results obtained revealed that β-sitosterol (1) exhibited significantly antidiabetic activity at all glucose concentrations with minimum increase 66.48% at 10µg/ml and maximum increase 74.46% at 80μg/ml glucose concentration. The Stigmasterol (2) showed good membrane stabilizing activity in HRBC, the minimum stabilization 62.74% at 10μg/ml and maximum stabilization 65.19% at 40μg/ml. These results showed that this plant is very important from medical point of view and it needs further phytochemical investigation to explore its hidden medicinal potential.

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Antiulcerogenic activity of Indigofera truxillensis Kunth

Cited by 15 publications

References 31 publications

Evaluation of Antiulcer Activity of Wedelia Calendulacea Aqueous Extract in Rodents

Evaluation of Antiulcer Activity of Wedelia Calendulacea Aqueous Extract in Rodents

Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

Isolation and Biological Activity of β-Sitosterol and Stigmasterol from the Roots of Indigofera heterantha

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