Studies on activity of various extracts of Mentha arvensis Linn against drug induced gastric ulcer in mammals

Abstract

AIM:To examine the antiulcerogenic effects of various extracts of Mentha arvensis Linn on acid, ethanol and pylorus ligated ulcer models in rats and mice. METHODS:Various crude extracts of petroleum ether, chloroform, or aqueous at a dose of 2 g/kg po did not produce any signs or symptoms of toxicity in treated animals. In the pyloric ligation model oral administration of different extracts such as petroleum ether, chloroform and aqueous at 375 mg/kg po , standard drug ranitidine 60 mg/kg po and control group 1% Tween 80, 5 mL/kg po to separate groups of Wister rats of either sex (n = 6) was performed. Total acidity, ulcer number, scoring, incidence, area, and ulcer index were assessed. RESULTS:There was a decrease in gastric secretion and ulcer index among the treated groups i.e. petroleum ether (53.4%), chloroform (59.2%), aqueous (67.0%) and in standard drug (68.7%) when compared to the negative control. In the 0.6 mol/L HCl induced ulcer model in rats (n = 6) there was a reduction in ulcerative score in animals receiving petroleum ether (50.5%), chloroform (57.4%), aqueous (67.5%) and standard. drug (71.2%) when compared to the negative control. In the case of the 90% ethanol-induced ulceration model (n = 6) in mice, there was a decrease in ulcer score in test groups of petroleum ether (53.11%), chloroform (62.9%), aqueous (65.4%) and standard drug ranitidine (69.7%) when compared to the negative control. It was found that pre-treatment with various extracts of Mentha arvensis Linn in three rat/mice ulcer models ie ibuprofen plus pyloric ligation, 0.6 mol/L HCl and 90% ethanol produced significant action against acid secretion (49.3 ± 0.49 vs 12.0 ± 0.57, P < 0.001). Pre-treatment with various extracts of Mentha arvensisLinn showed highly -significant activity against gastric ulcers (37.1 ± 0.87 vs 12.0 ± 0.57, P < 0.001). CONCLUSION:

Biophenols of mints: Antioxidant, acetylcholinesterase, butyrylcholinesterase and histone deacetylase inhibition activities targeting Alzheimer’s disease treatment

“…f Previously reported by Oinonen et al (2006), Kapp (2015) and Londonkar and Poddar (2009) in M. arvensis.…”

Antiulcer activity of the chloroform extract ofBauhinia purpurealeaf

“…Other than that, flavonoids have been shown to scavenge free radicals (Londonkar & Poddar, 2009) and could be responsible for the recent report on the antioxidant activity of CEBP (Zakaria et al, 2011). This is further supported by Shetty et al (2008) who discussed that flavonoids could possibly inhibit the gastric mucosal injury by scavenging the ethanol-and indomethacin-generated oxygen metabolites.…”

“…hydroperoxy and superoxide anion free radicals) resulting from the metabolism of ethanol and these ROS will take part in the mechanism of acute and chronic ulceration in the gastric mucosa. Several studies have reported that ROS and lipid peroxidation will initially attack and damage many biological molecules (e.g., prostaglandins) followed by a continuing chain of reactions that will lead to cell injury and ultimately cell death (Londonkar & Poddar, 2009). The ability of CEBP to reduce ethanol-induced gastric ulcer in the present study suggests the involvement of its cytoprotective effect, which could be associated with the antioxidant and free radical scavenging effects of the extract.…”

Medicinal Plants as Remedies for Gastrointestinal Ailments and Diseases

“…Being a hybrid, it is usually sterile, producing no seeds and reproducing only vegetatively, spreading by its rhizomes. Scientific studies have shown that the petroleum ether, chloroform, or aqueous extract (375 mg kg À1 oral) was effective in preventing ibuprofen plus pyloric ligation-, 0.6 mol l À1 HCl-, and 90% ethanol-induced gastric ulcerations in rats (Londonkar and Poddar, 2009). It prevents smooth muscle contractions and can be used for relief from abdominal pain associated with irritable bowel syndrome.…”