Medicinal Plants as Remedies for Gastrointestinal Ailments and Diseases

Arora, Rajesh; Malhotra, Poonam; Sundriyal, S.; Yashavanth, Holalu Shivashankaregowda; Pai, Ramakrishna J.; Baliga, Manjeshwar Shrinath

doi:10.1016/b978-0-12-397154-8.00033-6

Cited by 5 publications

(3 citation statements)

References 34 publications

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“…As anti-oxidant, it is proved that both the in vitro and in vivo antioxidant potentials of Aloe vera polysaccharide could be further utilized in relevant industrial applications (Kang et al 2014). As gastrointestinal, some commonly used medicinal plants such as Aloe vera or Aloe arborescens in the treatment of gastrointestinal ailments (Arora et al 2013). As hepatoprotective, Aloe vera had induced acute liver damage (Kanat et al 2006).…”

Section: Alternative Uses Of Aloe Veramentioning

confidence: 99%

Potential of Aloe Vera L. For Enhancing the Value Added of Agriculture Sector in the New Reclaimed Lands

Hawary

Abdu

Salah

2017

Fayoum Journal of Agricultural Research and Development

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Aloe vera is well known as good potential source for maintaining health conditions for both human and animal life as well. Nevertheless, the adoption of Aloe vera by Egyptian farmers is considered very low. This is attributed to the lack of information farmers possess about the cultivation, agricultural practices and economic benefits of Aloe vera at both individual and national levels as well. The major contribution of Aloe vera is derived from its industrial utilization. One of the important pharmaceutical properties that have recently been discovered for both the Aloe vera gel and whole leaf extract is the ability to improve the bioavailability of co-administrated vitamins in human subjects. Furthermore, the dried powder obtained from Aloe vera gel was successfully used to manufacture directly compressible matrix type tablets. The major theme of this paper is to raise the awareness of Aloe vera plant to both growers and policy makers in Egypt about the importance of Aloe vera and its huge uses in different cosmetic and pharmaceutical products. In addition to raise Egypt's national income and provide employment opportunities through an increase the value added of the agriculture sector. Finally using the new reclaimed lands as the GOE, is moving towards reclamation of 1.5 million feddans which requires innovation of new paradigm in development the agricultural sector. Adoption of Aloe vera in the new lands can be good example for development of agriculture in a new fashion and enhancing added value of the sector and hence the national income will be increased. This paper is conducted to demonstrate associations or relationships among different variables that affect the farmer's adoption of Aloe vera in the new reclaimed lands and the consumers attitudes towards demand for such products that contain Aloe vera and in particular cosmetics and pharmaceutical products. At the farm level, cross data is collected in a one time interview with the available Aloe vera farmer in El-Fayoum Governerate in 2014. Another survey was conducted to collect data about consumer's habits and preferences regarding demand for Aloe vera products between three consumer classes at different hours and different types of retail stores. The questionnaire was designed and protested. Data for 1146 consumers were collected, coded and analyzed. Results Emad Zaky El Hawary et al.

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Section: Alternative Uses Of Aloe Veramentioning

confidence: 99%

Potential of Aloe Vera L. For Enhancing the Value Added of Agriculture Sector in the New Reclaimed Lands

Hawary

Abdu

Salah

2017

Fayoum Journal of Agricultural Research and Development

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“…There are a variety of factors that hinder absorption of drugs into the gastrointestinal tract (GIT), with low water solubility and/or low permeability of the substance as major factors. GIT is a long tubular tract representing the set of organs that extends from mouth to anus, but usually refers to the stomach and intestine [3]. For absorption through the oral route, drugs must first dissolve in GIT fluid before permeating through GIT membranes to reach the blood.…”

Section: Introductionmentioning

confidence: 99%

How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions: Optimization and In-Vitro Characterization

et al. 2022

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The purpose of this study is to improve the solubility and dissolution of a poorly soluble drug, Irbesartan, using solid dispersion techniques. For that purpose, different polymers such as Soluplus®, Kollidon®VA 64, Kolliphor®P 407, and Polyinylpyrrolidone (PVP-K30) were used as carriers at different concentrations to prepare solid dispersion formulations through the solvent evaporation method. In order to prepare binary dispersion formulations, Soluplus® and Kollidon®VA 64 were used at drug:polymer ratios of 1:1, 1:2, 1:3, and 1:4 (w/w). Saturation solubility of the drug in the presence of used carriers was performed to investigate the quantitative increase in solubility. Dissolution studies were performed to explore the drug release behavior from the prepared dispersions. Additionally, the characterization of the prepared formulations was carried out by performing DSC, SEM, XRD, and FTIR studies. The results revealed that among binary systems, K4 formulation (Drug:Kollidon®VA 64 at ratio of 1:4 w/w) exhibited optimal performance in terms of increased solubility, drug release, and other investigated parameters. Furthermore, ternary dispersion formulations of the optimized binary formulation were prepared with two more polymers, Kolliphor®P 407 and Polyvinylpyrrolidone (PVP-K30), at (Drug:Kollidon®VA 64:ternary polymer) ratios of 1:4:1, 1:4:2, and 1:4:3 (w/w). The results showed that KPVP (TD3) exhibited the highest increase in solubility, as well as dissolution rate, among ternary solid dispersion formulations. Results of solubility enhancement by ternary solid dispersion formulations were also supported by FTIR, DSC, XRD, and SEM analysis. Conclusively, it was found that the ternary solid dispersion-based systems were more effective compared to the binary combinations in improving solubility as well as dissolution of a poorly soluble drug (Irbesartan).

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“…A wide range of active ingredients such as alkaloids, steroids, diterpenoids, lactones, glycosides, sesquiterpenoids, phenolics, polysaccharides, and aliphatic compounds have been isolated from the different parts of the plant, including, stem, root, and whole plant [ 2 , 3 ]. T. cordifolia is known for its antispasmodic, anti-inflammatory, antidiabetic, antiallergic, antipyretic, and analgesic properties and is being used in the treatment of gout, jaundice, rheumatism, urinary disorder, diabetes, anemia, skin diseases and infections [ 4 , 5 , 6 , 7 ]. According to the Ayurveda (Indian medicine) literature, the phytoactive ingredients of T. cordifolia are to a constituent of several formulations which is used for the treatment of dyspepsia, urinary, and general debility diseases [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

TinoTranscriptDB: A Database of Transcripts and Microsatellite Markers of Tinospora cordifolia, an Important Medicinal Plant

Singh

Mahato

Singh

et al. 2022

Genes

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Tinospora cordifolia, commonly known as “Giloe” in India, is a shrub belonging to the family Menispermaceae. It is an important medicinal plant known for its antipyretic, anti-inflammatory, antispasmodic, and antidiabetic properties and is used in the treatment of jaundice, gout, and rheumatism. Despite its economic importance, the limited information related to its genomic resources prohibits its judicious exploitation through molecular breeding or biotechnological approaches. In this study, we generated a meta-transcriptome assembly of 43,090 non-redundant transcripts by merging the RNASeq data obtained from Roche 454 GS-FLX, and Illumina platforms, and report the first transcriptome-based database for simple sequence repeats and transcription factors (“TinoTranscriptDB” (Tinospora cordifolia Transcriptome Database)). We annotated 26,716 (62%) of the total transcripts successfully from National Center for Biotechnology Information non-redundant protein (NCBI-NR), gene ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Swiss-Prot, and Pfam databases. This database contains information of 2620 perfect simple sequence repeats (P-SSRs) with a relative abundance of 340.12 (loci/Mb), and relative density of 6309.29 (bp/Mb). Excluding mono-nucleotides, the most abundant SSR motifs were tri-nucleotides (54.31%), followed by di-nucleotides (37.51%), tetra-nucleotides (4.54%), penta-nucleotides (3.16%) and hexa-nucleotides (0.45%). Additionally, we also identified 4,311 transcription factors (TFs) and categorized them into 55 sub-families. This database is expected to fill the gap in genomic resource availability in T. cordifolia and thus accelerate molecular breeding and related functional and other applied studies aimed towards genetic improvements of T. cordifolia and related species.

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Medicinal Plants as Remedies for Gastrointestinal Ailments and Diseases

Cited by 5 publications

References 34 publications

Potential of Aloe Vera L. For Enhancing the Value Added of Agriculture Sector in the New Reclaimed Lands

Potential of Aloe Vera L. For Enhancing the Value Added of Agriculture Sector in the New Reclaimed Lands

How to Improve Solubility and Dissolution of Irbesartan by Fabricating Ternary Solid Dispersions: Optimization and In-Vitro Characterization

TinoTranscriptDB: A Database of Transcripts and Microsatellite Markers of Tinospora cordifolia, an Important Medicinal Plant

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