Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice

Bento, Elizângela Beneval; Júnior, Francisco Elizaudo de Brito; Oliveira, Dayanne Rakelly de; Fernandes, Cícera Norma; Delmondes, Gyllyandeson de Araújo; Cesário, Francisco Rafael Alves Santana; Rodrigues, Cristina Kelly de Sousa; Sales, Valterlúcio dos Santos; Figuêiredo, Francisco Rodolpho Sobreira Dantas Nóbrega de; Lemos, Izabel Cristina Santiago; Monteiro, Álefe Brito; Menezes, Irwin Rose Alencar de; Costa, José Galberto Martins da; Kerntopf, Marta Regina

doi:10.1016/j.sjbs.2016.01.024

Cited by 23 publications

(14 citation statements)

References 37 publications

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“…One animal study utilised ethanolic leaf extract at a dose of 25–100 mg/kg demonstrated sedative, anxiolytic and anticonvulsant‐like effect . Antiulcerative ( n = 3) effects of A. muricata hydroalcoholic, ethanolic and ethyl acetate leaf extracts were identified when administered orally over the dose range of 10–400 mg/kg. Of the three studies which investigated A. muricata leaf extract in renal effect, two studies demonstrated a nephroprotective effect, while one demonstrated a nephrotoxic effect with no substantial differences in the dose, formulation or route of administration.…”

Section: Resultsmentioning

confidence: 99%

The safety and tolerability of Annona muricata leaf extract: a systematic review

Chan

McLachlan

Hanrahan

et al. 2020

Journal of Pharmacy and Pharmacology

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Objectives Annona muricata, also known as graviola, soursop and guanabana, has been widely utilised for the treatment of a range of cancers. The mechanism of action and the efficacy of A. muricata and its constituents in the treatment of cancer have been comprehensively reviewed. The aim of this systematic review was to summarise the available literature that reports on factors related to the safety and tolerability of A. muricata leaf extract and its acetogenins. Methods In‐vitro, preclinical animal studies and human studies of any design written in any language were included. Studies that evaluated A. muricata leaf extract and its constituents were searched through the databases Pubmed, Medline and Embase from inception to April 2019. The elaborated item 4 of Consolidated Standards of Reporting Trials statement and Animals in Research: Reporting In vivo Experiments guidelines were used to evaluate the quality of the studies. Key findings The results suggest that A. muricata and its constituents have hepatoprotective, neurotoxic, antinociceptive, anti‐ulcerative and chemopreventive effects. The dose and duration used in animal studies demonstrating toxicity may not directly translate into the effects in humans. Studies included in this review were judged to be of medium to high quality. Conclusions The overall outcome of the current review suggests that A. muricata has a favourable safety and tolerability profile. Future studies investigating its use in people diagnosed with a range of cancers are warranted.

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Section: Resultsmentioning

confidence: 99%

The safety and tolerability of Annona muricata leaf extract: a systematic review

Chan

McLachlan

Hanrahan

et al. 2020

Journal of Pharmacy and Pharmacology

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“…Besides the anti-inflammatory and anticancer properties, the leaves of A. muricata have also been thoroughly investigated for other pharmacological and biological properties. Bento et al revealed that the A. muricata leaves showed significant antiulcer activity against lesions (Bento et al, 2016 ). Besides that, a remarkable wound healing properties by the ethyl acetate leaf extract of A. muricata has been discovered by Moghadamtousi et al ( 2015b ).…”

Section: Other Biological Activities Of Annona Muricata mentioning

confidence: 99%

Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents

et al. 2018

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The use of anti-inflammatory natural products to treat inflammatory disorders for cancer prevention and therapy is an appealing area of interest in the last decades. Annona muricata L. is one of the many plant extracts that have been explored owing to their anti-inflammatory and anticancer effects. Different parts of A. muricata especially the leaves have been used for various ethnomedicinal purposes by traditional healers to treat several diseases including cancer, inflammation, diabetes, liver diseases, and abscesses. Some of these experience-based claims on the use of the plant have been transformed into evidence-based information by scientific investigations. The leaves of the plant have been extensively investigated for its diverse pharmacological aspects and found eminent for anti-inflammatory and anticancer properties. However, most studies were not on the bioactive isolates which were responsible for the activities but were based on crude extracts of the plant. In this comprehensive review, all significant findings from previous investigations till date on the leaves of A. muricata, specifically on their anti-inflammatory and anticancer activities have been compiled. The toxicology of the plant which has been shown to be due to the presence of neurotoxic annaceous acetogenins and benzyltetrahydro-isoquinoline alkaloids has also been updated to provide recent information on its safety aspects. The present knowledge of the plant has been critically assessed, aimed at providing direction toward improving its prospect as a source of potential anti-inflammatory and anticancer agents. The analysis will provide a new path for ensuring research on this plant to discover new agents to treat inflammatory diseases and cancer. Further in vitro and in vivo studies should be carried out to explore the molecular mechanisms underlying their anti-inflammatory responses in relation to anticancer activity and more detail toxicity study to ensure they are safe for human consumption. Sufficient preclinical data and safety data generated will allow clinical trials to be pursued on this plant and its bioactive compounds.

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“…Studies about plants from the Brazilian Cerrado has increased considerably. These plants include graviola ( Annona muricata Linnaeus), which has displayed anti-ulcerogenic effects [ 24 ], bocaiuva ( Acrocomia aculeata ) which has presented anti-diabetic properties [ 25 ] and anti-inflammatory and diuretic actions [ 26 ], and baru ( Dipteryxalata Vog. ), which was observed to cause improvement in lipid profiles and atherogenic indexes [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions

et al. 2018

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Obesity, in conjunction with other metabolic disorders such as insulin resistance and dyslipidemia, is a feature of metabolic syndrome which is characterized by a pro-inflammatory state and increased oxidative stress. Therefore, antioxidant foods are proposed to prevent and treat these disorders. Medicinal plants are one of the main strategies in this regard. Guavira, a Brazilian Cerrado plant, contains different bioactive compounds with a high antioxidant capacity and without clinical or reproductive toxicity effects. Though there are different varieties of guavira, the principal Brazilian Cerrado guaviras demonstrated hypoglycemic, anti-inflammatory, and hypocholesterolemic actions. There is also a potential antiplatelet agent in C. xanthocarpa, while C. adamantium displayed hypocholesterolemic actions in animal models and human clinical trials. On the other hand, even with a lack of studies related to C. pubescens, it demonstrated anti-inflammatory effects and an antioxidant capacity in in vitro studies. Despite the fact that most of the studies were not performed to evaluate pathological conditions specific to obese animal models or obese subjects, guavira demonstrated effects in metabolic disorders that are commonly related to the obesity context, such as cardiovascular disturbances and hyperglycemia status. This suggests that guavira is a potential therapeutic approach to obesity-induced metabolic syndrome.

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Antiulcerogenic activity of the hydroalcoholic extract of leaves of Annona muricata Linnaeus in mice

Cited by 23 publications

References 37 publications

The safety and tolerability of Annona muricata leaf extract: a systematic review

The safety and tolerability of Annona muricata leaf extract: a systematic review

Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents

Therapeutic Potential of Brazilian Cerrado Campomanesia Species on Metabolic Dysfunctions

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