Linnaeus, popularly known as "graviola" and also called soursop, is a species typical of countries with a tropical climate, and it is used in folk medicine as an anticancer, analgesic and antispasmodic agent. The aim of the present study was to validate the gastroprotective activity of the hydroalcoholic extract of the leaves of (HEAM) and to investigate the underlying mechanisms of action for this effect. Gastric lesions were induced in mice by absolute ethanol, acidified ethanol or indomethacin. Before, the animals were pretreated with saline, omeprazole or HEAM orally at doses of 50-400 mg/kg. To determine the mechanism of action of the extract, we investigated, using specific inhibitors, the involvement of nitric oxide (NO), prostaglandins (PGEs), ATP-dependent K channels and α2-noradrenergic receptors. HEAM showed significant antiulcer activity against lesions induced by absolute ethanol, acidified ethanol or indomethacin, which was mediated by endogenous gastric prostaglandins.
O leite materno é o alimento básico para o recém-nascido. Ele oferece inúmeros benefícios fisiológicos, com adequadas quantidades de nutrientes, elementos imunogênicos que representam a primeira imunização passiva da criança. Contribui com benefícios a mãe, a criança, a família, e deve ser incentivado principalmente através de orientações e estratégias educativas durante os períodos pré e pós natais mediadas por equipe multidisciplinar de saúde. Uma combinação única de proteínas, lipídios, carboidratos, minerais, vitaminas, enzimas e células vivas, assim como benefícios nutricionais imunológicos, desenvolvimento, especialmente para o prematuro, devido a sua maior vulnerabilidade. Este trabalho teve como objetivo avaliar a prática de profissionais de saúde na promoção e no apoio à amamentação. O estudo trata-se de uma revisão integrativa da literatura, identificando as contribuições dos estudos referentes à aleitamento materno na literatura brasileira. A amamentação é influenciada pelo o ambiente, considera-se importante trabalhar nas instituições de saúde que atendem puérperas e RNs, nas unidades de alojamento conjunto e neonatal, e humanização em saúde. A pesquisa revelou que amamentação é um desafio para o profissional de saúde, e que estes precisam ser sempre capacitados para trabalhar a promoção do aleitamento materno.
Croton campestris A. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract of C. campestris leaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found that C. campestris represents a promising natural source with important biological potential, justifying some of its uses in folk medicine.
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