Association Between Food and Drugs: Antimicrobial and Synergistic Activity of <i>Annona muricata</i> L.

Bento, Elizângela Beneval; Matias, Edinardo Fágner Ferreira; Brito, Francisco Elizaudo de; Oliveira, Dayanne Rakelly de; Coutinho, Henrique Douglas Melo; Costa, José G.M.; Kerntopf, Marta Regina; Menezes, Irwin Rose Alencar de

doi:10.1080/10942912.2011.565905

Cited by 28 publications

(33 citation statements)

References 22 publications

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“…The primary mechanism of fluconazole's action occurs by the inhibition of the fungal enzyme lanosterol 14 α -demethylase (CYP51), which is a cytochrome enzyme P-450, involved in the synthesis of the ergosterol, the most important sterol in the fungal cell membrane [ 36 ]. It is known that many medicinal plants may modulate the activity of several antimicrobial agents [ 37 , 38 ]. In a previous study, the aqueous extract of the leaves and fractions of D. furfuracea when combined with aminoglycosides presented synergic activity against Escherichia coli and Staphylococcus aureus [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, the isolation and the activity of alkaloids and acetogenines have stood out in studies with plants of the Annonaceae family. The biological activity as antimicrobial capacity and antioxidant activity present in A. muricata can be attributed to the presence of acetogenines [ 37 , 45 ]. Alkaloids as aphorphinoids present the bark of Annona salzmannii D. C. was responsible for the antioxidant and antimicrobial capacity [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

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Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.‐Hill

Pinho

Cruz

Rodrigues

et al. 2016

Oxidative Medicine and Cellular Longevity

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Background. Duguetia furfuracea is popular plant used in popular medicine. Hypothesis/Purpose. This claim evaluated the phytochemical composition of the hydroethanolic extract (HEDF), fractions of Duguetia furfuracea, and antioxidant and antifungal activity. Methods. The chemical profile was carried out by HPLC-DAD. The total phenolic contents and flavonoid components were determined by Folin-Ciocalteu and aluminium chloride reaction. The antioxidant activity was measured by scavenging of 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and ferric reducing ability of plasma (FRAP) methods. The antifungal activity was determined by microdilution assay. Results. HPLC analysis revealed caffeic acid and rutin as major compounds (HEDF), caffeic acid and quercitrin (Mt-OH fraction), and quercitrin and isoquercitrin (Ac-OEt fraction). The highest levels of phenols and total flavonoids were found for Ac-OEt fraction, and the crude extract showed higher in vitro antioxidant potential. The antifungal activity showed synergic effect with fluconazole and EHDF against C. krusei, fluconazole and Mt-OH against C. krusei and C. tropicalis, and Ac-OE and fluconazole against C. albicans. Conclusion. The highest levels of phenols and total flavonoids were marked with antioxidant effect. This is the first report of bioactivity of the synergic effect of HEDF and fractions. More studies would be required to better clarify its mechanism of synergic action.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.‐Hill

Pinho

Cruz

Rodrigues

et al. 2016

Oxidative Medicine and Cellular Longevity

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“…Its presence in both fruits and leaves of Annona muricata is an indication of how useful these parts can be in the management of such conditions. Some bioactivities previously shown for extracts from leaves and fruits of Annona muricata include antioxidant, 33,49 anti-bacterial, [50][51][52][53] anti-inflammatory, 54 anti-viral, 55 anti-diabetic, 28 antineoplastic and anticancer, 13,23,[30][31][32][33][34][35][36][37] among others. We therefore further propose that these compounds play important roles in relation to some of the above-named bioactivities.…”

Section: General Discussion Of the Lc/sq Ms Resultsmentioning

confidence: 99%

Liquid Chromatography Single Quadrupole Mass Spectrometry (LC/SQ MS) Analysis Reveals Presence of Novel Antineoplastic Metabolites in Ethanolic Extracts of Fruits and Leaves of Annona muricata

Gavamukulya¹,

Maina²,

Meroka³

et al. 2019

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Annona muricata L. 6 The Annona muricata tree is about 5-10 m tall and 15-83 cm in diameter with low branches. 7-9 It is widely distributed in the tropical regions of Central and South America, Western Africa, Central and Eastern Africa and Southeast Asia 3,6 at altitudes below 1200 m above sea level, with temperatures between 25 and 28°C, relative humidity between 60 and 80% and annual rainfall above 1500 mm. The fruit is an edible collective ovoid berry, dark green in color. Various medicinal uses have been reported across the globe ranging from the use of leaves, bark, roots, fruits and seeds of Annona muricata. 10 The most widely used preparation in traditional medicine is the decoction of bark, root, seed or leaf but applications are varied. Ethnobotanical studies have indicated that Annona muricata has been used as insecticide 11 and parasiticide. 12 Fruit juice and infusions of leaves ABSTRACT Background: Annona muricata, a tropical plant species belonging to family Annonaceae is one of the most used plants in folk medicine because of its many medicinal uses. Despite its wide usage, there is still need to continue scientifically evaluating its medicinal properties in order to avoid any adverse effects. Elucidating the detailed chemical composition of this plant is a significant step towards this evaluation. Objective: The aim of this study was to conduct LC MS analysis on the ethanolic extracts of fruits and leaves of Annona muricata for detection of novel metabolites. Materials and Methods: Leaves and fruits of Annona muricata were collected from Eastern Uganda during the month January 2018. Extraction was conducted using the tissue homogenization method and the extracts were analyzed on an LC/SQ MS detection system. The results were obtained by analyzing the MS spectra using the retentions time and fragmentation patterns on the NIST Library. Results: The study revealed that the fruits extracts contain 1,3-Dimethylthiourea and (4-chlorophenyl)-[4-(3-chlorophenyl)-2-[(Z)-3-(dimethylamino) prop-1-enyl]quinolin-6-yl]-(3-methylimidazol-4-yl)methanol, which are reported antioxidant and antineoplastic agents. The leaves contained 2,4,6-Tribromoaniline another antioxidant and antineoplastic agent, while compound (dichlorozirconium(2+);dimethyl-bis(2-methyl-4phenylinden-1-id-1-yl)silane was found in both extracts of fruits and leaves. Conclusion: The current study suggests that ethanolic extracts of fruits and leaves of Annona muricata contain compounds which are potent antioxidant, antineoplastic and therapeutic agents for various conditions and paves the way for the development of several treatment regimens from these plant parts. Finally, the compounds reported in this study have been identified for the first time as being found in Annona muricata.

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“…Annona muricata , belonging to the family of Annonaceae, is distributed in tropical and subtropical areas such as Brazil, India, Philippines, and Central America. It is commonly knowns as ‘graviola’ and its leaves have been used for a variety of health problems by local communities because of its healing effects on headache, infections, diabetes, insomnia, and inflammation ( 1 , 2 ).…”

Section: Introductionmentioning

confidence: 99%

Structural Characterization of Cellulose Obtained from Extraction Wastes of Graviola (Annona muricata) Leaf

Choi

Kang

Lim³

et al. 2018

pnf

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Cellulose is one of the most common functional ingredients in food products and has been widely used as fat replacers and stabilizers. In the present study, the structural properties of cellulose obtained from extraction wastes of graviola (Annona muricata.) leaf (CWG) were characterized via scanning electron microscope (SEM), X-ray diffraction (XRD), fourier transform-infrared (FTIR), and 13C nuclear magnetic resonance (NMR) analyses. Extraction and purification of CWG were accomplished by alkali treatment and bleaching processes. An elongated, fibrous structure of CWG was observed in SEM analysis. The XRD, FTIR, and 13C NMR spectra of CWG were compared with microcrystalline cellulose (control cellulose) and it was found that CWG exhibited similar structural characteristics to the control. XRD diffractogram of CWG showed typical peaks (2θ=15° and 22.6°) of cellulose I. According to the specific peaks (898, 1,057, and 1,430 cm−1) and chemical shifts (104.5, 88.5, 72~75, and 64.6 ppm) obtained by FTIR and NMR analyses, respectively, it was cofirmed that cellulose was successfully extracted from CWG.

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Association Between Food and Drugs: Antimicrobial and Synergistic Activity of Annona muricata L.

Cited by 28 publications

References 22 publications

Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.‐Hill

Phytochemical Composition, Antifungal and Antioxidant Activity of Duguetia furfuracea A. St.‐Hill

Liquid Chromatography Single Quadrupole Mass Spectrometry (LC/SQ MS) Analysis Reveals Presence of Novel Antineoplastic Metabolites in Ethanolic Extracts of Fruits and Leaves of Annona muricata

Structural Characterization of Cellulose Obtained from Extraction Wastes of Graviola (Annona muricata) Leaf

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