Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves of<i>Croton campestris</i>A. St.-Hill in Rodents

Júnior, Francisco E. B.; Oliveira, Dayanne Rakelly de; Bento, Elizângela Beneval; Leite, Laura Hévila Inocêncio; Souza, Daniele Oliveira; Siebra, Ana Luiza A.; Sampaio, Renata Souza; Martins, Anita O. P. B.; Ramos, Andreza Guedes Barbosa; Tintino, Saulo Relison; Lacerda-Neto, Luiz J.; Figueiredo, P.; Oliveira, Larissa Rolim de; Rodrigues, Cristina K. S.; Sales, Valterlúcio S.; Figueiredo, Francisco R. S. D. N.; Nascimento, Emmily Petícia do; Monteiro, Álefe Brito; Amaro, Érika N.; Costa, José G.M.; Coutinho, Henrique Douglas Melo; Menezes, Irwin Rose Alencar de; Kerntopf, Marta Regina

doi:10.1155/2013/579346

Cited by 9 publications

(4 citation statements)

References 35 publications

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“…They are rich in phenolic groups and are chemically classified into hydrolysable and condensed (Paes, Diniz, Marinho, & Lima, 2006). Studies on the pharmacological properties of tannins suggest a significant antibacterial action (Loguercio, Battistin, Vargas, Henzel, & Witt, 2005;Oliveira et al, 2006), as well as anti-inflammatory (Norata et al, 2007), antiparasitic (Morais-Braga et al, 2013) and gastroprotective (Júnior et al, 2013;Pellizzon et al, 2012) activities.…”

Section: Chemical Analysismentioning

confidence: 99%

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

et al. 2015

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The aim of this study was to evaluate the chemical profile and antioxidant, antimicrobial and antiparasitic activities of the hydroalcoholic extract of the leaves of Ziziphus joazeiro Mart. (HELZJ). The antioxidant DPPH and FRAP assays and chemical profile were determined by colorimetric methods and HPLC/DAD. The antiparasitic, antibiotic and antibiotic-modifying activity were evaluated by microdilution assays. The HPLC-DAD assay showed the presence of mostly tannins and flavonoids, such as caffeic acid and quercetin. The levels of polyphenols and flavonoids were 183.136 mg/g extract and 7.37 mg/g extract, respectively. DPPH and FRAP showed low antioxidant activity for the extract. The antibacterial and antifungal activities were not of clinical relevance, showing MIC>1024 μg/mL. However, synergism was observed between HELZJ and the antibiotics amikacin and gentamicin, which resulted in decreased bacterial drug resistance. EHFZJ showed low toxicity in fibroblasts in vitro, while antiparasitic results against Trypnosoma cruzi, Leishmania braziliensis and Leishmania infantum were not clinically relevant. Thus, our results indicate that Z. joazeiro Mart. (HELZJ) could be a source of plant-derived natural products that could lead to the development of promising new antibiotic compounds for infectious diseases.

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Section: Chemical Analysismentioning

confidence: 99%

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

et al. 2015

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“…Substantial evidence from the literature indicates that Croton campestris A. St.-Hill displays antibacterial [14,15], antibiotic [15,17], molluscicidal [18], and antiinflammatory properties [19]. Recently, our research group reported the antiulcerogenic activity of the leaf extracts of Croton campestris A. St.-Hill [16]. However, the possible mechanism by which Croton campestris A. St.-Hill exerts this action was not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

“…The genus Croton is composed of 700 species and is distributed in tropical regions. It is popularly known as "velame do campo" and is used through infusions of leaves and roots of the plant in alcoholic beverages and teas and is used in Brazilian folk medicine for gastric, hematological, and inflammatory disorders, as well as respiratory problems [14][15][16]. Substantial evidence from the literature indicates that Croton campestris A. St.-Hill displays antibacterial [14,15], antibiotic [15,17], molluscicidal [18], and antiinflammatory properties [19].…”

Section: Introductionmentioning

confidence: 99%

Croton campestris A. St.-Hill Methanolic Fraction in a Chlorpyrifos-Induced Toxicity Model in Drosophila melanogaster: Protective Role of Gallic Acid

Gomes

Macedo

Rodrigues

et al. 2020

Oxidative Medicine and Cellular Longevity

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Croton campestris A. St-Hill popularly known as “velame do campo” is a native species of the savannah from northeastern Brazil, being used in folk medicine due to its beneficial effects in the treatment of many diseases, inflammation, detoxification, gastritis, and syphilis; however, its potential use as an antidote against organophosphorus compound poisoning has not yet been shown. Here, the protective effect of the methanolic fraction of C. campestris A. St.-Hill (MFCC) in Drosophila melanogaster exposed to chlorpyrifos (CP) was investigated. Flies were exposed to CP and MFCC during 48 h through the diet. Following the treatments, parameters such as mortality, locomotor behavior, and oxidative stress markers were evaluated. Exposure of flies to CP induced significant impairments in survival and locomotor performance. In parallel, increased reactive oxygen species and lipoperoxidation occurred. In addition, the activity of acetylcholinesterase was inhibited by CP, and superoxide dismutase and glutathione S-transferase activity was induced. Treatment with MFCC resulted in a blockage of all CP-induced effects, with the exception of glutathione S-transferase. Among the major compounds found in MFCC, only gallic acid (GA) showed a protective role against CP while quercetin and caffeic acid alone were ineffective. When in combination, these compounds avoided the toxicity of CP at the same level as GA. As far as we know, this is the first study reporting the protective effect of MFCC against organophosphate toxicity in vivo and highlights the biotechnological potential of this fraction attributing a major role in mediating the observed effects to GA. Therefore, MFCC may be considered a promising source for the development of new therapeutic agents for the treatment of organophosphate intoxications.

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“…(bom-nome; Mota et al, 2008), Croton campestris A. St.-Hill (Júnior et al, 2013), Croton urucurana Baillon bark (urucuana) (Cordeiro et al, 2012), Campomanesia xanthocarpa O. Berg (gabiroba; Markman et al, 2004).…”

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A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

et al. 2017

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ResumoO saber popular sobre plantas medicinais tem auxiliado estratégias de bioprospecção de espécies e direcionado o estudo para a descoberta de novas atividades farmacológicas. O objetivo desta pesquisa foi identificar espécies medicinais utilizadas contra úlcera gástrica pela comunidade do Povoado Vila Capim, Arapiraca, Alagoas e, avaliar a atividade antiulcerogênica gástrica da espécie mais saliente. Para a seleção dos informantes-chave utilizou-se a técnica da bola de neve e aplicadas entrevistas semiestruturadas. A análise das falas foi pela técnica do Discurso do Sujeito Coletivo. Para os testes farmacológicos foram utilizados ratos Wistar machos no modelo de lesão gástrica aguda induzida por etanol absoluto. A toxicidade aguda foi avaliada. Dezessete informantes-chave indicaram os sintomas e plantas medicinais utilizadas contra a úlcera gástrica. A espécie com maior valor de saliência foi a Solanum stipulaceum (sacatinga), escolhida para testes químicos e farmacológicos. O extrato aquoso bruto (SSaq) apresentou atividade significativa na dose de 200 mg kg -1 (p<0,05), sendo capaz de inibir lesões (91,35%). O extrato etanólico (SSet) demonstrou atividade gastroprotetora nas doses de 200 e 400 mg kg -1 (p<0.01), com inibição de 71,12% e 76,38%, respectivamente. É necessário aprofundar os estudos para a elucidação dos compostos químicos das folhas da espécie, toxicologia e identificação dos mecanismos de ação subjacentes à atividade gastroprotetora de S. stipulaceum.Palavras-chave: Plantas medicinais, bioprospecção, análise de saliência, ensaios in vivo. Applied ethnobotany to gastric ulcer and pharmacological evaluation of Solanum stipulaceum AbstractThe popular knowledge about medicinal plants has helped the bioprospecting strategies of species and directed to a discovery of new pharmacological activities. The aim of this study was to identify medicinal species used against gastric ulcer in the Vila Capim village, Arapiraca, Alagoas, and it evaluating a gastric anti -inflammatory activity of the most salient species. For a selection of key informants has used a snowball technique. The TCLE was signed and semi-structured interviews were applied. The analysis of the speeches was done on the Discourse of the Collective Subject technique. For pharmacological experimental tests, plant extract was underwent the Acute Gastric Lesion Model induced by absolute ethanol and using Wistar male rats. Acute toxicity was evaluated. Seventeen key informants indicated the symptoms and the medicinal plants used against gastric ulcer. The species with the highest salience value was Solanum stipulaceum Roem & Schult (sacatinga), chosen for chemical and pharmacological tests. The crude aqueous extract (SSaq) presented significant activity at a dose of 200 mg kg -1 (p<0.05), being able to inhibit lesions (91.35%). Ethanolic extract (SSet) showed gastroprotective activity at doses of 200 and 400 mg kg -1 (p <0.01), with inhibition of (71.12% and 76.38%), respectively. Further studies will be need for analysis of toxicit y and id...

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Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves ofCroton campestrisA. St.-Hill in Rodents

Cited by 9 publications

References 35 publications

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

Croton campestris A. St.-Hill Methanolic Fraction in a Chlorpyrifos-Induced Toxicity Model in Drosophila melanogaster: Protective Role of Gallic Acid

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

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