Antibacterial and modulatory effect of<i>Stryphnodendron rotundifolium</i>

Oliveira, Dayanne Rakelly de; Brito-Junior, Francisco E.; Bento, Elizângela Beneval; Matias, Edinardo Fágner Ferreira; Sousa, Ana Carla A.; Costa, José G.M.; Coutinho, Henrique Douglas Melo; Kerntopf, Marta Regina; Menezes, Irwin Rose Alencar de

doi:10.3109/13880209.2011.589857

Cited by 20 publications

(12 citation statements)

References 42 publications

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“…Due to this fact, there is currently a growing search for new natural or synthetic compounds capable of inhibiting at low concentrations the metabolism of various species of multiresistant microorganisms (Silveira, Nome, Gesser, & Terenzi, 2006). Interest in combining natural products and synthetic antibiotics has gained prominence, because natural products mat potentiate the activity of clinically used drugs Oliveira et al, 2011). HELZJ has shown a significant modulatory effect, when amikacin and gentamicin were combined with it, resulting in greater toxicity to E. aerogenes (Fig.…”

Section: Antibiotic and Antibiotic-modifying Activitymentioning

confidence: 99%

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

et al. 2015

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The aim of this study was to evaluate the chemical profile and antioxidant, antimicrobial and antiparasitic activities of the hydroalcoholic extract of the leaves of Ziziphus joazeiro Mart. (HELZJ). The antioxidant DPPH and FRAP assays and chemical profile were determined by colorimetric methods and HPLC/DAD. The antiparasitic, antibiotic and antibiotic-modifying activity were evaluated by microdilution assays. The HPLC-DAD assay showed the presence of mostly tannins and flavonoids, such as caffeic acid and quercetin. The levels of polyphenols and flavonoids were 183.136 mg/g extract and 7.37 mg/g extract, respectively. DPPH and FRAP showed low antioxidant activity for the extract. The antibacterial and antifungal activities were not of clinical relevance, showing MIC>1024 μg/mL. However, synergism was observed between HELZJ and the antibiotics amikacin and gentamicin, which resulted in decreased bacterial drug resistance. EHFZJ showed low toxicity in fibroblasts in vitro, while antiparasitic results against Trypnosoma cruzi, Leishmania braziliensis and Leishmania infantum were not clinically relevant. Thus, our results indicate that Z. joazeiro Mart. (HELZJ) could be a source of plant-derived natural products that could lead to the development of promising new antibiotic compounds for infectious diseases.

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Section: Antibiotic and Antibiotic-modifying Activitymentioning

confidence: 99%

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

et al. 2015

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“…It is traditionally used by northeastern Brazilian populations for various types of inflammation, such as uterine, general, skin, and throat inflammation, as well as being potentially indicated as a cicatrizant and for the treatment of cancer [72]. It is considered a promising species for bioprospecting, since it has already demonstrated activity as an antioxidant [73], leishmanicidal and trypanocidal activity [74], and antimicrobial activity [75, 76]. …”

Section: Resultsmentioning

confidence: 99%

Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study

Macedo

Menezes

Ribeiro

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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Ethnopharmacological Relevance This study aims to evaluate the versatility of these species and their agreement of use and/or the informants' knowledge and verify the variability of the information on the indicated medicinal species in comparison to other species from northeastern Brazilian areas. Materials and Methods Ethnobotanical information was acquired through interviews with 23 residents of the Quincuncá community, northeastern Brazil. From the obtained data, a comparative analysis of the therapeutic indications with other 40 areas in different biomes was conducted. For that, the relative importance index and informant consensus factor were calculated and compared to other indices evaluated in the literature. Results A total of 39 medicinal species were cited and twenty-six species showed similarities among their therapeutic indications; however, species as Geoffroea spinosa, Lantana camara, and others can be highlighted, present in community disease indications that were not verified for other areas. Myracrodruon urundeuva, Mimosa tenuiflora, Stryphnodendron rotundifolium, and Amburana cearensis had the greatest versatility. In the Quincuncá community, medicinal species were indicated for 49 diseases, which were grouped into 15 categories of body systems. Conclusion This study shows the presented divergence in relation to their therapeutic use; in this point, these divergences reinforce the importance of pharmacological research.

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“…Some of these plants have been previously studied, with different solvents, parts and sometimes using different strains and different methodological approachs. [23][24][25][26][27][28][29][30][31][32][33][34][35][36] Although, there are some reports concerning antimicrobial activities of some of the plants tested (Table 9), the main difficulties in comparing previous studies, lies in the fact that the criteria, method and end-points used for reporting the activity are very diverse. As can be seen in the table in the case of Gossypium barbadense, the minimum concentration used in the study by Ikobi et al 32 and regarded to represent antibacterial activity, is considered in our study to be too high (10 folds increase compared to the maximum dose we utilized), and regarded as not having activity.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial Screening of Medicinal Plants Popularly used in Mato Grosso for Treating Infections: Advances on the Evaluation of Conyza bonariensis (L.) Cronquist in vitro and in vivo Antibacterial Activities

Paula¹,

Martins²,

Arunachalam³

et al. 2018

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infections and resistance to antifungal agents have increased significantly in immunocompromised patients and these infections are responsible for a high rate of morbidity/mortality in severe cases. 1,4 The growing need for more effective and safe antimicrobial agents has led to the renewal of multidisciplinary investigation on natural products, where new approaches combined with traditional techniques, are accelerating tracking of substances, which present antimicrobial activities. In addition, it has also allowed identification of the molecular targets responsible for their effects, moreover, many of these substances present new mechanisms of action. 4 Medicinal plants constitute an arsenal of chemicals

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Antibacterial and modulatory effect ofStryphnodendron rotundifolium

Cited by 20 publications

References 42 publications

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

Analysis of bioactivities and chemical composition of Ziziphus joazeiro Mart. using HPLC–DAD

Analysis of the Variability of Therapeutic Indications of Medicinal Species in the Northeast of Brazil: Comparative Study

Antimicrobial Screening of Medicinal Plants Popularly used in Mato Grosso for Treating Infections: Advances on the Evaluation of Conyza bonariensis (L.) Cronquist in vitro and in vivo Antibacterial Activities

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