Antiulcerogenic and Antibacterial Effects of Chitosan Derivatives on Experimental Gastric Ulcers in Rats

Abstract

Gastric ulcer is an injury that develops on the lining of the stomach due to an imbalance between aggressive and defensive agents. Chitosan derivatives demonstrate promising biological activities in accelerating the healing activity of gastric lesions. Thus, this study aimed at investigating the healing activity of gastric lesion, induced by acetic acid (80%), of the chitosan derivative with acetylacetone (Cac) modified with ethylenediamine (Cacen) or diethylenetriamine (Cacdien). The biological activity was determined based on cytotoxicity, antibacterial activity, and gastroprotective activities. The results showed no significant difference in the cytotoxicity, a better antibacterial activity against S. aureus and E. coli, and a positive result on the healing of gastric lesions of the materials (Cac 18.4%, Cacen 55.2%, and Cacdien 68.1%) compared to pure chitosan (50.7%). Therefore, the results indicate that derivatives of chitosan are promising biomaterials for application in the control of lesions on the gastric mucosa.

Protective Effect of the Phycobiliproteins from Arthrospira maxima on Indomethacin-Induced Gastric Ulcer in a Rat Model

“…Within our experimental design, IND was used as a positive control to study gastric damage produced by a COX-2 non-selective NSAID, while CTD was employed as a protective drug for IND-induced gastric damage against which to compare the gastroprotective effect of PBPs. The doses of the substances used in this experiment were taken from those reported in the literature to produce gastric ulcers with IND [61], to protect against gastric damage with CTD [62], and from previous studies in our laboratory in which PBPs showed good antioxidant and anti-inflammatory effects between doses 100 to 400 mg/kg [32].…”