Antiulcerogenic Compounds Isolated from Chinese Cinnamon

Tanaka, Shigeo; Yoon, Young Hwa; Fukui, Hiroshi; Tabata, Minoru; Taneno, Akira; Okano, Kanemichi; Iwai, Masakazu; Iga, Yoshiro; Yokoyama, Kazumasa

doi:10.1055/s-2006-961994

Cited by 48 publications

(29 citation statements)

References 10 publications

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“…To regain the balance, different therapeutic agents including herbs and spices have been used to inhibit the gastric acid secretion and/or to boost the mucosal defense mechanism by enhancing mucus production (Baggio et al, 2003). The current data clearly demonstrated that cinnamon suspension significantly decreased basal gastric acid secretion and completely inhibited the ulceration in pylorus ligated Shay rats, which concurs with earlier reports of antisecretory and antiulcerogenic actions of two phytoconstituents isolated from Chinese cinnamon (Cinnamon cassia) (Tanaka et al, 1989). In a recent study, Unlu et al (2010) of C. zeylanicum bark.…”

Section: Discussionsupporting

confidence: 90%

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Anti-secretagogue and antiulcer effects of Cinnamon Cinnamomum zeylanicum in rats

Alqasoumi¹

2012

J. Pharmacognosy Phytother.

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The present study was carried out to evaluate the gastric antisecretory and antiulcer activities of 'Cinnamon' Cinnamomum zeylanicum in rats. The aqueous suspension of cinnamon (250 and 500 mg/kg) has been screened using pylorus ligation (Shay) rat model, necrotizing agents and indomethacin-induced ulceration in rats. Histopathological assessment was done on gastric tissue of rats. Gastric wall mucus and nonprotein-sulfhydryl contents were also estimated. Cinnamon suspension pretreatment decreased the basal gastric acid secretion volume and rumenal ulceration in pylorus ligated rats. The suspension effectively inhibited gastric hemorrhagic lesions induced by 80% ethanol, 0.2 M sodium hydroxide, and 25% sodium chloride. The cinnamon suspension also showed antiulcer activity against indomethacin. Pretreatment with cinnamon suspension offered a dosedependent protection against various histological indices. Treatment of rats with cinnamon replenished the ethanol-induced decreased levels of gastric wall mucus and nonprotein-sulfhydryl concentrations. The gastroprotection of cinnamon observed in the present study is attributed to its effect through inhibition of basal gastric secretion (attenuation of aggressive factors) and stimulation mucus secretion (potentiation of defensive factors); and increase in nonprotein-sulfhydryl concentration probably due to prostaglandin-inducing abilities mediated through its antioxidant property.

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Section: Discussionsupporting

confidence: 90%

“…However, the volatile oil of cinnamon and its constituents are known to offer protection against gastric damage caused by aggressors in animal models that might be through antioxidant properties (Tanaka et al, 1989). The principal constituents of cinnamon bark are volatile oil, tannins, mucilage, gum, resins, and coumarins.…”

Section: Discussionmentioning

confidence: 99%

Anti-secretagogue and antiulcer effects of Cinnamon Cinnamomum zeylanicum in rats

Alqasoumi¹

2012

J. Pharmacognosy Phytother.

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“…Chinese cinnamon (Tanaka et al, 1989) have antiulcer activity; licorice (Revers, 1956), Saussuria lappa Clark (Bose et al, 1961;Gupta and Ghatak, 1967), clove (Debelmas and Rochat, 1967) and Asarum sieboldii Miq. (Itokawa et al, 1983) have spasmolytic activity; and licorice possesses gastric secretion inhibitory effect (Hakanson et al, 1973;Takagi and Harada, 1969;Yu, 1976).…”

Section: Introductionmentioning

confidence: 99%

Effects of Ya-hom on the gastric secretion in rats

Suvitayavat

Kodchawongs

Thirawarapan

et al. 2004

Journal of Ethnopharmacology

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“…PS, 15,16) CB, 17,18) BR, 19,20) MB, 21,22) and JV 23) are reported scientifically proven to have an effect on those clinical condition. Here, these drugs significantly improved BF in stress-enhanced mice (Figs.…”

Section: Modification Of Stress Schedulementioning

confidence: 98%

Development of an Assay Method to Search for Compounds Inhibiting Stress-Enhanced Allergy

Oku

Kanaya

Ishiguro

2016

Biological & Pharmaceutical Bulletin

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Stress exacerbates allergic disorders such as atopic dermatitis and asthma. It is also an important factor affecting blood flow (BF). Allergic reactions also affect blood flow. For example, we observed that mice sensitized with hen egg-white lysozyme (HEL) have decreased BF during the allergy induction phase. Based on this finding, we established a model for evaluating chronic restraint stress-enhanced allergies. Mice were sensitized with 12.5 µg/head of HEL on day 0, then restrained for 90 min daily on days 1-3, 5, and 6 in a modified 50 mL polystyrene conical centrifuge tube with multiple air holes for ventilation. We used the decrease in BF during that time as a guide for developing an in vivo assay for substances that can inhibit stress-enhanced allergies. Finally, we demonstrated the utility of the new method by testing crude drugs that are used solely or in combination with other crude drugs to treat stress-related illness and neuropsychiatric symptoms. Our model should be useful for identifying potential anti-stress-enhanced allergy drugs.Key words allergy; chronic restraint stress; blood flow; crude drug; egg-white lysozyme Allergic diseases, such as atopic dermatitis and asthma, become severe or relapse due to stress. However, there have been no systems that can evaluate allergy enforced by stress.As stress is an important factor affecting blood flow (BF), we have developed a new assay system based upon our findings 1-3) on BF decrease in the induction phase of allergy in the tail vein of mice sensitized by use of hen egg-white lysozyme (HEL). We previously developed an in vivo assay to search natural resources for allergy-preventive substances. We used it to assess BF during the allergy induction phase in the tail veins of mice that have been sensitized to HEL. 1-3) Blood flow in the model appears to be regulated by various factors such as nitric oxide, thromboxane A 2 (TXA 2 ), prostacyclin (PGI 2 ), and endothelin-1 (ET-1) together with cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), inducible nitric oxide synthase (iNOS), and constitutive nitric oxide synthase (cNOS). 1) A reduction of BF occurs via two pathways. One is an iNOS-independent response involving TXA 2 and ET-1; and the other is an iNOS-dependent response involving cyclooxygenase COX-1, COX-2, and PGI 2 . 2) Its clinical condition is also similar to the "oketsu" (the state of blood stagnation) of the Kampo medicine (a traditional medicine practiced in Japan, based on ancient Chinese medicine). 3) In our continuing search for allergy-preventive substances from natural sources using this assay method. [4][5][6][7] On the other hand, allergic disorders become severe or relapse due to stress. 8,9) It also affects the production of substances such as interleukin and tumor necrosis factor, which cause allergies and inflammation. 10) Additionally, stress is an important factor affecting BF. 11-13) However, assay for compounds that inhibit stress-enhanced allergy have been unavailable. Therefore, we developed a novel assay system based upon ...

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Antiulcerogenic Compounds Isolated from Chinese Cinnamon

Cited by 48 publications

References 10 publications

Anti-secretagogue and antiulcer effects of Cinnamon Cinnamomum zeylanicum in rats

Anti-secretagogue and antiulcer effects of Cinnamon Cinnamomum zeylanicum in rats

Effects of Ya-hom on the gastric secretion in rats

Development of an Assay Method to Search for Compounds Inhibiting Stress-Enhanced Allergy

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