Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Ofusori, Adebimpe Esther; Moodley, Roshila; Jonnalagadda, Sreekantha B.

doi:10.1016/j.jtcme.2019.11.004

Cited by 24 publications

(16 citation statements)

References 24 publications

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“…[3,29,32,37] In the current study, rats pre-nourished with gold nanoparticle enhanced construction of stomach mucosa increase wide improvement protein concentration in gastric secretions. [38,39] Significances of the present exercise were similar with other amendments quantity gastroprotective and antiulcer achievement gold nanoparticle and herbal composites. [4,40,41] Pre-feeding with the gold nanoparticle, challengingly impassable gastric acid likewise takeover stomach injury in rats forced feeding ethanol, characteristic gastro-protective effect gold nanoparticle easy relatively protection of gastric wall.…”

Section: Discussionsupporting

confidence: 67%

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Shareef

Hadi

‎

et al. 2022

Cihan U Erbil SCI J

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Synthesis of gold nanoparticles exhibition wide range of bioactivities and was conventionally used for the remedy of numerous disorders. Our study aims to measure the gastroprotective effect of synthesized gold nanoparticles on absolute ethanol-induced stomach ulceration in rats. The rats were noticeably administered with two doses of gold nanoparticles (175 ppm and 350 ppm) with absolute alcohol and showed a significant improvement in the adverse effect of ethanol-produced stomach damage as confirmed by decreasing ulcer index and raising % of ulcer prevention. Increased mucus pH of stomach content reduced ulcerated portion, condensed or nonappearance of edema, and white blood cells permeation subcutaneous layer. In gastric tissue homogenate, synthesized gold nanoparticles presented a substantial increase in superoxide dismutase (SOD), catalase (CAT) actions, and a substantial lessening of malondialdehyde (MDA) amount. Besides, gold nanoparticle increases the intensity of periodic acid Schiff stained (PAS) of the gastric epithelium of the stomach. Gold nanoparticles confirmed gastro-protective effects which might be qualified to its antioxidant, increase mucus secretion, increase endogenous enzymes (SOD and CAT), and reduce MDA quantity.

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Section: Discussionsupporting

confidence: 67%

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Shareef

Hadi

‎

et al. 2022

Cihan U Erbil SCI J

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“…Similarly, several academics using medicinal plants or their active ingredients reported a flatting of the gastric mucosa and the anti-ulcer effects of stomach mucosa in rats; indeed, a previous study has shown the anti-ulcer effects of Celosia trigyna in 50 mg/kg dosage against ethanol-induced ulcers in rats. Furthermore, another research team have demonstrated Monolluma quadrangula to be an anti-ulcer medicinal plant after showing its efficacy in 150 or 300 mg/kg dosage against ethanol-induced ulcers in rats [7,50].…”

Section: Discussionmentioning

confidence: 99%

“…Ethanol is a necrotizing agent that induces oxidative stress and stomach mucosal ulceration through the generation of highly cytotoxic free radicals [4,5]. Oxygen-derived free radical species induced by ethanol administration are among the mucosal invasive factors responsible for peptic ulcers by causing oxidative damage to gastric mucosal cells [6,7]. The exogenous and endogenous active oxygen and oxidants (superoxide dismutase and single oxygen peroxidase) can easily cause damage to gastric mucosal linings.…”

Section: Introductionmentioning

confidence: 99%

Gastroprophylactic Effects of p-Cymene in Ethanol-Induced Gastric Ulcer in Rats

et al. 2022

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The prevalence of gastric ulcers has increased in recent years, mainly because of non-steroidal anti-inflammatory drug utilization. Therefore, the current study investigates the gastroprotective effect of p-Cymene on absolute ethanol-induced acute gastric mucosal hemorrhagic lesions in rats. Thirty Sprague Dawley rats were randomly separated into five groups: normal control, ulcer control, reference, and two experimental groups. The normal and ulcer control groups were orally fed with 0.5% carboxymethylcellulose (CMC). The reference group was fed orally with 20 mg/kg omeprazole. The experimental groups were fed with 30 mg/kg and 60 mg/kg p-Cymene, respectively. After one hour, the normal group was fed with 0.5% CMC, and groups 2–5 were given absolute alcohol. After another hour all rats were sacrificed. The ulcer control group showed severe superficial hemorrhagic gastric mucosal lesions with decreased gastric mucus secretion and pH of gastric content. p-Cymene significantly reduced ethanol-induced gastric lesions, as evidenced by increased mucus and pH of gastric content, decreased ulcer area, reduced or absence of edema, and leucocyte infiltration of the subcutaneous layer. In gastric mucosal homogenate, p-Cymene displayed a significant increase in superoxide dismutase (SOD), catalase (CAT) activities, prostaglandin E2 (PGE2), and significantly reduced the malondialdehyde (MDA) level. In addition, p-Cymene increased the intensity of periodic acid–Schiff (PAS) stain of the gastric epithelium, and produced up-regulation of the HSP 70 protein and down-regulation of the Bax protein of the stomach epithelium, as well as a reduction in the levels of tumor necrotic factor-alpha and interleukin-6, while the level of interleukin-10 was increased. p-Cymene decreased the level of TNF-a and IL-6, and increased the level of IL-10. Acute toxicity with a higher dose of 500 mg/kg p-Cymene did not manifest any toxicological signs in rats and could enhance defensive mechanisms against gastric mucosal lesions. p-Cymene showed gastroprotective effects that could be attributed to its antioxidant nature, or its ability to increase mucus secretion, increase endogenous enzymes (SOD, CAT, PGE2), reduce MDA level, up-regulate HSP 70 protein, down-regulate Bax protein, and modulate inflammatory cytokines.

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“…Microscopic scores were calculated, based on the following parameters: edema or hemorrhage, loss of mucosal folding, and mucosal discoloration. The number of ulcers were counted, and ulcer severity was determined 22 23 . Below is the ulcer score: 0=Normal colored stomach, 0.5=Red coloration, 1.0=Spot ulcers, 1.5=Hemorrhagic streaks, 2.0=Deep ulcer, and 3.0=Perforations.…”

Section: Methodsmentioning

confidence: 99%

Lupeol: A Triterpenoid Isolated from the Stem Bark of Hymenocardia Acida (tul.) Exhibits a van der Waal Antagonism on the Alpha Subunit of Gastric H+K+Atpase – A Promising Antiulcer Principle

Oluwasegun,

Ogochukwu,

Ugochukwu

et al. 2023

Drug Res (Stuttg)

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Background Hymenocardia acida (HA) is one of the numerous medicinal plants in Nigeria with ethnomedicinal history of usage in the treatment of ulcer. The study aimed at isolating antiulcer principle(s) from the stem bark of HA as well as the mechanism of action determination. Methods Antiulcer screenings of the crude extract, aqueous fraction, and bulked VLC fractions were performed using in vivo and in vitro models. Docking was carried out by using PyRx. Results Crude extract (HA; 1 mg/mL) and the aqueous fraction of H. acida (HAA; 1 mg/mL) showed an acid neutralizing capacity (MEq) of 0.3948 and 0.4035, respectively which is significantly different from 0.431 MEq showed by negative control (distilled water) at p<0.05. BVLC 3 (1 mg/mL) showed a significant value of 0.4049 MEq. However, HA showed a dose-dependent decrease in activity across doses examined, with 100 mg/kg showing an ulcer index of 10.00±2.89 (61.50%) and cimetidine (positive control; 100 mg/kg), also showed the highest ulcer index of 3.67±0.88 (85.9%), which is significantly different from ulcer index of 26.00±6.35 (0.00%) p<0.05 observed in the negative control (5% dimethylsulphoxide). The highest ulcer index of 8.00±1.32 (65.10%) was noted in BVLC 3. Bioactive BVLC 3, resulted in an isolated compound (BF3B2A). The compound was suggested to be lupeol, with a docking score of −7.7. It showed a van der Waal interaction with some key amino acid residues in the vonoprazan binding site. Conclusion The experimental studies justify the ethnomedicinal claim of usage among locals.

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Antiulcerogenic effects of Celosia trigyna plant extracts on ethanol-induced gastric ulcer in adult Wistar rats

Cited by 24 publications

References 24 publications

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Green Synthesis of Gold Nanoparticles Using Zingiber Officinale Rhizomes Aqueous Extract and its Gastroprotective Activity Against Ethanol-Produced Stomach Ulcer in Rodents

Gastroprophylactic Effects of p-Cymene in Ethanol-Induced Gastric Ulcer in Rats

Lupeol: A Triterpenoid Isolated from the Stem Bark of Hymenocardia Acida (tul.) Exhibits a van der Waal Antagonism on the Alpha Subunit of Gastric H+K+Atpase – A Promising Antiulcer Principle

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