Antiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra cauliflora

Wahab, Noor Zarina Abd; Azizul, Aziah; Badya, Norhidayah; Ibrahim, Nazlina

doi:10.5530/pj.2021.13.96

Cited by 8 publications

(16 citation statements)

References 18 publications

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“…For this reason, scientific studies have been conducted on the antimicrobial activities of plant extracts against various types of microorganisms, which have arisen in the evolution of alternative plant-based antimicrobial pharmaceutical medicines. 29,30,31,32 Extracts and some natural phytoconstituents found in the Myrtaceae family have been reported to have anticancer, antimicrobial, antioxidant, and anti-inflammatory properties. 33,34,35,36 Qualitative determination of phytochemicals showed the presence of flavonoids, saponins, and condensed tannins in all parts of this plant.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antibacterial Activity of Essential Oils of Melaleuca cajuputi Powell

Wahab¹,

Ja’afar²,

Ismail³

2022

J. Pure Appl. Microbiol.

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Melaleuca cajuputi Powell is a tree species belonging to the family Myrtaceae and is widely used in traditional medicine. This study was conducted to investigate the antibacterial activities of essential oils of M. cajuputi Powell. Antibacterial activity was tested against Gram positive and Gram negative bacteria using the agar disc diffusion method. The essential oils of M. cajuputi were found to exert antibacterial activity against all of the tested bacteria, including Staphylococcus aureus, Streptococcus pyogenes, methicillin-resistant Staphylococcus aureus (MRSA), Klebsiella pneumoniae, and Escherichia coli. The zones of inhibition for S. aureus, S. pyogenes, MRSA, E. coli, and K. pneumoniae were 12.7 mm, 10.7 mm, 10.0 mm, 8.7 mm and 9.3 mm respectively, against 0.714% (w/w) of the essential oils. These results highlighted that Gram negative bacteria are less susceptible to the essential oils of M. cajuputi. A large zone of inhibition might be a sign of a leaching antimicrobial agent. These findings suggest that M. cajuputi is a potential natural antibacterial agent.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Antibacterial Activity of Essential Oils of Melaleuca cajuputi Powell

Wahab¹,

Ja’afar²,

Ismail³

2022

J. Pure Appl. Microbiol.

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“…A methanol leaf extract showed significant antioxidant [15,60,62,63]; antibacterial (against Staphylococcus aureus, Escherichia coli, Porphyromonas gingivalis, and methicillinresistant Staphylococcus aureus [33,62,67]); anti-viral (against herpes simplex virus type 1) [71]; anti-diabetic; antidiarrheal (in vivo) [63]; and cytotoxic potentiality against brine shrimp (Artemia salina) and Vero cells [71,72]. An ethanol leaf extract showed anti-inflammatory activity by inhibiting the activities of arachidonate-5-lipoxygenase and hyaluronidase [64].…”

Section: Biological Studiesmentioning

confidence: 99%

The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data

Sabiha

Serrano

Hasan

et al. 2022

Plants

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Cynometra L. is a Fabaceae genus that is widely distributed throughout the tropics, consisting of tropical forest trees with ecological and economic importance since they are used as food and herbal medicines by the populations of their natural habitats. Our goal is to provide a review of the research data concerning the potential of this botanical genus as a source of herbal medicines and secondary metabolites that are useful for human health. To that end, scientific databases, including PubMed, Science Direct, ISI Web of Science, Scopus, and Google Scholar, were searched using the following terms: Cynometra, medicine, chemical, biological activity, toxicity, and “AND” as the Boolean connector. Eleven Cynometra species (9.7%) were reported to be used in traditional medicine to treat different ailments. A total of 185 secondary metabolites of various chemical classes, mainly flavonoids and terpenoids, were identified in eight Cynometra species (7.1%). Vitexin was the only flavonoid identified as bioactive in the sequence of bioguided studies on this botanical genus. Ten species (8.8%) were submitted to in vitro and in vivo biological activity assays. The main evaluated activities were in vitro antioxidant, antimicrobial, cytotoxic, and in vivo anti-inflammatory activities, but no human clinical trials or safety data about this genus were found. Cynometra cauliflora and Cynometra ramiflora were the most studied species. The present work confirms the use of Cynometra species as a source of medicinal plants. However, more experimental studies must be conducted to better understand this botanical genus’s usefulness as a source of raw materials for pharmaceutical use.

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“…The assay was conducted as reported by a previously published method [28]. Initially, Vero cells (2.5× 10 6 cells/well) were seeded into 24-well plate and incubated for 24 h. Cells were pre-treated with different concentrations of extract (1-31 µg/mL) for 24 h before being withdrawn and infected with 300 µL of virus at 50 PFU.…”

Section: Pre-treatment Of Plant Extract On Hsv-1-infected Cellsmentioning

confidence: 99%

In vitro virucidal activity of Kyllinga nemoralis aqueous extract against herpes simplex virus

Wahab¹,

Ganasen²,

Rahman³

et al. 2022

J App Biol Biotech

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Kyllinga nemoralis is an ignored plant distributed in tropical, subtropical, and warm temperature regions around the world. K. nemoralis plant is rich with bioactive molecules exhibiting antiherpetic properties. This study determined the antiviral activities of K. nemoralis stem with leaves aqueous extract against herpes simplex virus type 1 (HSV-1). The stem with leaves of K. nemoralis plant was extracted using aqueous extraction method. The cytotoxicity of K. nemoralis extract was evaluated using a cell viability assay. Plaque reduction assays were carried out to estimate the antiviral activity of K. nemoralis extract against HSV-1. Antiviral studies consisted of post-treatment, pre-treatment, and virucidal assay. Cell viability assay revealed K. nemoralis stem with leaves aqueous extract is non-toxic toward Vero cells. K. nemoralis stem with leaves aqueous extract inhibited HSV-1 replication in Vero cells with 50% effective concentration (EC 50 ) = 0.004 mg/mL and selective index (SI) = 14 when given after adsorption to the cells. The EC 50 against HSV-1 was 0.013 mg/mL and SI = 4.31 when cells were treated 24 h before virus infection. K. nemoralis stem with leaves aqueous extract exhibited direct virucidal activity against HSV-1 with EC 50 = 0.0065 mg/mL and SI = 8.62. The results presented the potential of K. nemoralis as an anti-HSV-1 agent by the following modes: direct damage to viral particle, interruption of virus attachment, and suppression of viral replication cycle.

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Antiviral Activity of an Extract from Leaves of the Tropical Plant Cynometra cauliflora

Cited by 8 publications

References 18 publications

Evaluation of Antibacterial Activity of Essential Oils of Melaleuca cajuputi Powell

Evaluation of Antibacterial Activity of Essential Oils of Melaleuca cajuputi Powell

The Genus Cynometra: A Review of Ethnomedicine, Chemical, and Biological Data

In vitro virucidal activity of Kyllinga nemoralis aqueous extract against herpes simplex virus

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