Antiviral Activity of Copper(ii)chloride Dihydrate Against Dengue Virus Type-2 in Vero Cell

Abstract

Infection of dengue virus (DENV) was number of globally significant emerging pathogen. Antiviral dengue therapies are importantly needed to control emerging dengue. Dengue virus (DENV) is mosquito-borne arboviruses responsible for causing acute systemic diseases and grievous health conditions in humans. To date, there is no clinically approved dengue vaccine or antiviral for humans, even though there have been great efforts towards this end. Copper and copper compounds have more effective in inactivation viruses, likes an influenza virus and human immunodeficiency virus (HIV). Purpose in this project was investigated of Infeksi virus dengue (DENV) adalah patogen yang muncul secara global. Terapi antivirus dengue penting diperlukan untuk mengontrol muncul dengue. Dengue virus (DENV) disebabkan oleh mosquito-borne arboviruses yang menyebabkan penyakit sistemik akut dan kondisi kesehatan pada manusia. Sampai saat ini, tidak ada vaksin dengue klinis disetujui atau antivirus bagi manusia, meskipun telah ada upaya besar menjelang akhir ini. Tembaga dan senyawa tembaga memiliki efektivitas dalam inaktivasi virus, seperti virus influenza dan human immunodeficiency virus (HIV). Tujuan dalam proyek ini adalah menyelidiki senyawa antiviral

Anti-Dengue Type 2 Virus Activities of Zinc (Ii) Complex Compounds With 2-(2,4 -Dihydroxyphenyl)-3,5,7-Trihydroxycromen-4-One Ligands in Vero Cells

“…17 The effects of other compounds against cellular RNA polymerases and formation of the complex with RNA have reported suggesting that compound could also affect the similar replication enzymes. 18 Previous research was reported anti-dengue type 2 activity, especially Cu(II) with 2,4,5-triphenylimidazole exhibited adsorption inhibitory activity at IC 50 = 2.3 μg/ml. 11 A significant inhibitory activity to that of the complex Co(II) with 2-(2,4-dihydroxyphenyl)-3,5,7trihydroxycromen -4-one ligand was reported against the tested pathogenic dengue virus type 2 in Vero cells 3.08 μg/ ml.…”

Inhibitory Activity of Cobalt(ii)–morin Complex Against the Replication of Dengue Virus Type 2

“…13 When compared with a previous study, it has been revealed that Co(II) is more toxic than Cu(II) with a CC 50 value of 5.03 µg/ml. 18 Copper(II) was found to be nontoxic to human erythrocyte cells even at a concentration of 500 µg/ml. 20 …”

“…The sI of the antiviral compound appeared to be moderately influenced by the strain of DENV tested. 18 The emergence of arboviruses worldwide raises the necessity of developing a new strategy for the treatment of the diseases they cause. several approaches have been demonstrated for the treatment of DENV-2 in which Cobalt(II)-Morin at concentrations of micrograms per milliliter promote inactivation.…”

Can Nanotechnology and Materials Science Help the Fight against SARS-CoV-2?

“…Specifically, the use of copper salt nanoparticles and/or solutions (chloride, iodide, sulfide, etc. ), which are known for having an antiviral effect [54][55][56][57][58], could be helpful in the development of PPE with improved shielding properties. As an example, the treatment of non-woven overshoes, surgical gowns, hair cups, respirators, etc.…”