1978
DOI: 10.1128/aac.14.1.24
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Antiviral Activity of Extracts from Marine Algae

Abstract: Extracts of two species of marine algae, Constantinea simplex and Farlowia mollis , were tested for antiviral activity in tissue culture and in experimental infections of mice. Treatment of confluent mouse embryo fibroblast cell monolayers with either compound before viral inoculation was effective in inhibiting the replication of herpes simplex virus type 1 and type 2, vaccinia virus, and vesicular stomatitis virus, but not encephalomyocarditis virus, Semliki Fo… Show more

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Cited by 65 publications
(32 citation statements)
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“…In 1958, Gerber et aI., reported that algal polysaccharides exhibited antiviral activity towards mumps and influenza B viruses. Ehresmann et al (1977) linked the inhibition of herpes simplex and other viruses with polysaccharide fractions from extracts of ten red algae; similar observations were made by Richards et al (1978). More recently, Nakashima et al (1987aNakashima et al ( , 1987b, have characterized the HIV reverse transcriptase inhibitory sulphated polysaccharide from the red alga Schizymenia pacifica.…”
Section: Introductionmentioning
confidence: 60%
“…In 1958, Gerber et aI., reported that algal polysaccharides exhibited antiviral activity towards mumps and influenza B viruses. Ehresmann et al (1977) linked the inhibition of herpes simplex and other viruses with polysaccharide fractions from extracts of ten red algae; similar observations were made by Richards et al (1978). More recently, Nakashima et al (1987aNakashima et al ( , 1987b, have characterized the HIV reverse transcriptase inhibitory sulphated polysaccharide from the red alga Schizymenia pacifica.…”
Section: Introductionmentioning
confidence: 60%
“…Here we demonstrated the antiviral activities of two sulphur-containing anionic exopolysaccharides from cyanobacterium A. platensis (TK V3) and from rhodophyt P. purpureum (EPS) against the OPV VACV and ECTV.So far, there have been few reports of anti-OPV polyanionic activities derived from phototrophic microorganisms [8,35]. Production of the compounds in monoseptic cultures of microalgae and cyanobacteria occurred in photo-bioreactors and can be scaled up successfully [36].…”
Section: Discussionmentioning
confidence: 99%
“…Secondary or primary metabolites from these organisms may be potential bioactive compounds of interest for the pharmacological industry (1). Special attention has been reported for antiviral, antibacterial and/or antifungal activities related to marine algae against several pathogens (3,5,6,7,8,13,14,17,20). As an efficient strategy of investigation, organic solvents have been used to extract the possible lipidsoluble active principles from macroalgae (11).…”
mentioning
confidence: 99%