Antiviral Activity of Homobasidiomycetes: Evaluation of 121 Basidiomycetes Extracts on Four Viruses

Amoros, M.; Boustie, J.; Py, M-L; Hervé, Vincent; Robin, Valérie

doi:10.1076/phbi.35.4.255.13308

Cited by 9 publications

(6 citation statements)

References 9 publications

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“…The anti-inflammatory effect of a mushroom methanolic extract can be linked to the in vitro inhibition of acetylcholinesterase and butyrylcholinesterase enzymes [ 18 ]. MP extracts with organic solvents have shown other in vitro actions related to inflammatory and infectious processes, such as antibacterial, antifungal, antitumoricidal, antiviral, antiplatelet, and antineutrophil aggregation activities [ 8 , 14 , 18 , 19 , 20 , 21 , 22 ]. The anti-inflammatory activity has partly been attributed to some lanostane-type triterpenoids and cinnamic acid, isolated from the mushroom, inhibiting in vitro NO production in phagocytes [ 20 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Georgiev

Vašíček

Dzhambazov

et al. 2022

JoF

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Macrolepiota procera (MP) is an edible mushroom used in the treatment of diabetes, hypertension and inflammation. However, the structure and biological effects of its polysaccharides (PSs) are unclear. This study investigates the structural features of a PS complex from MP (MP-PSC), its immunomodulatory activities and effects on probiotic and pathogenic bacteria. MP-PSC was obtained by boiling water, and PSs were characterized by 2D NMR spectroscopy. The immunomodulatory effects on blood and derived neutrophils, other leukocytes, and murine macrophages were studied by flow cytometry, chemiluminescence, spectrophotometry, and ELISA. The total carbohydrate content of MP-PSC was 74.2%, with glycogen occupying 36.7%, followed by β-D-glucan, α-L-fuco-2-(1,6)-D-galactan, and β-D-glucomannan. MP-PSC (200 μg/mL) increased the number of CD14+ monocyte cells in the blood, after ex vivo incubation for 24 h. It dose-dependently (50–200 μg/mL) activated the spontaneous oxidative burst of whole blood phagocytes, NO, and interleukin 6 productions in RAW264.7 cells. MP-PSC exhibited a low antioxidant activity and failed to suppress the oxidative burst and NO generation, induced by inflammatory agents. It (2.0%, w/v) stimulated probiotic co-cultures and hindered the growth and biofilm development of Escherichia coli, Streptococcus mutans and Salmonella enterica. MP PSs can be included in synbiotics to test their immunostimulating effects on compromised immune systems and gut health.

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Section: Introductionmentioning

confidence: 99%

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Georgiev

Vašíček

Dzhambazov

et al. 2022

JoF

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“…As a result of the study, it was determined that Trametes gibbosa, Tricholoma virgatum, Tricholoma portentosum, Cortinarius orellanoides, Cortinarius sanguineus and Lactarius torminosus species exhibited the best values against HSV-1 at 0.5-4.5 mg/mL concentrations. It was also reported that Trametes gibbosa, Tricholoma virgatum, Tricholoma portentosum, Tricholoma acerbum, Collybia maculata, Rozites caperata, Cortinarius sanguineus, Hypholoma fasciculare, Hypholoma sublateritium and Lactarius torminosus exhibited the best values against HSV-2 at concentrations of 0.25-3.0 mg/mL [27]. In a study conducted in Germany, the effect of triterpenes obtained from Ganoderma pfeifferi species on HSV-1 was investigated.…”

Section: Antiviral Activitymentioning

confidence: 91%

“…In a study conducted in France, the effect of ethanol and aqueous extract obtained from 121 fungal species on Poliovirus was investigated. As a result of the study, it was reported that Clitocybe nebularis, one of the species used, showed high activity with 1.0-5.0 mg/mL, Lepista inversa with 1.0-4.5 mg/mL, Mycena pura with 1.25-1.75 mg/mL and Lactarius torminosus with 0.5-2.5 mg/mL [27]. In a study conducted in Brazil, the effect of ethanol extract of Agaricus brasiliensis species on Poliovirus was investigated.…”

Section: Infectious Bursal Disease Virus (Ibdv Genusmentioning

confidence: 98%

Medicinal mushrooms: a comprehensive study on their antiviral potential

Sevindik¹,

Bal²,

Eraslan³

et al. 2023

pps

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Microbial diseases have become quite common in recent years. The interest in new antimicrobial drugs is increasing due to the possible side effects of synthetic drugs and the emergence of resistant microorganisms due to unconscious antimicrobial drug use. Mushrooms have the potential to be used as a natural resource in the fight against microorganisms. In this context, in this study, the effects of different fungal species against different viral diseases were compiled in the literature. According to the findings, it has been reported in the literature that many different mushroom species are effective against Herpes virus (HSV-1, HSV-2, BoHV-1, HCMV), Influenza (A, B, H1N1, H3N2, H5N1, H9N2) and Parainfluenza, Infectious bursal disease virus (IBDV), Poxvirus, Vaccinia virus, Poliovirus, Vesicular stomatitis viruses (VSV), Adenovirus, Syncytial virus (RSV), Dengue virus ( DENV-2), Human immunodeficiency virus (HIV), Hepatitis A, B, C virus, Feline calicivirus (FCV), Enterovirus, Coxsackievirus, Coronavirus, Infectious hematopoietic necrosis virus (IHNV), Newcastle disease virus (NDV) and Tobacco Mosaic virus (TMV). In this context, it is thought that mushrooms can be a very important natural resource against viruses.

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“…(Pleurotaceae) against Human herpes virus 1 (HSV-1) showed that the methanolic extracts had lower anti-HSV-1 activity than the aqueous extracts [9]. Amoros et al [10] tested extracts obtained from the basidiocarps of 121 Basidiomycota mushroom species as anti-HSV (types 1 and 2), anti-vesicular stomatitis virus, and antipoliovirus. The study reported that 11% of these extracts inhibited one or more than one virus, with more active species belonging to the Cortinariaceae and Tricholomataceae families than to the Boletaceae and Russulaceae families.…”

Section: Introductionmentioning

confidence: 99%

Antiviral Potential of Mushrooms in the Light of their Biological Active Compounds

2019

ARC Journal of Pharmaceutical Sciences

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Life-threaten diseases, especially those caused by viruses, require searching and investigation in order to find potent compounds and drugs. Mushrooms are promising sources of compounds showing bioactive potency whenever tested. This review highlights extracts and compounds originated from mushrooms fruiting bodies and or mycelia. Further studies are encouraged to discover novel potent antiviral compounds/ extracts or evaluate already known compounds extracted from those edible medicinal mushrooms.

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Antiviral Activity of Homobasidiomycetes: Evaluation of 121 Basidiomycetes Extracts on Four Viruses

Cited by 9 publications

References 9 publications

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Structural Features and Immunomodulatory Effects of Water-Extractable Polysaccharides from Macrolepiota procera (Scop.) Singer

Medicinal mushrooms: a comprehensive study on their antiviral potential

Antiviral Potential of Mushrooms in the Light of their Biological Active Compounds

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