Antiviral Activity Of Ribosome Inactivating Proteins In Medicine

Parikh, Bijal A.; Tumer, Nilgun E.

doi:10.2174/1389557043403800

Cited by 71 publications

(58 citation statements)

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“…144,145], whereas only a few type 2 RIPs were found to be active (e.g. those from Eranthis hyemalis [146] and some from S. nigra [147] [154,155] or mental symptoms [156] and caused allergic reactions [156].…”

Section: Antiviral and Other Antiparasitic Activitiesmentioning

confidence: 99%

“…The effect of RIPs on plant viruses, the first to be known, led to transfection of plants with RIP genes, to improve their resistance to viral infections. Indeed, some protection from some viruses was conferred to transfected plants by several type 1 RIPs [reviewed in refs 144,145]. and, although with less efficiency, by type 2 RIPs from S. nigra, SNA-I'[147] and SNA-V[148], but not by SNA-If from the same plant[149].…”

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confidence: 99%

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Ribosome-inactivating proteins: progress and problems

Stirpe

Battelli

2006

Cell. Mol. Life Sci.

321

225

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Ribosome-inactivating proteins (RIPs), mostly from plants, are enzymes which depurinate rRNA, thus inhibiting protein synthesis. They also depurinate other polynucleotide substrates. The biological activity of RIPs is not completely clarified, and sometimes independent of the inhibition of protein synthesis. There are differences in the cytotoxicity of RIPs and, consequently, in their toxicity to animals. Some RIPs are potent toxins, the best known being ricin, a potential biological weapon. New toxins have recently been identified. RIPs cause apoptotic and necrotic lesions, and induce production of cytokines causing inflammation. RIPs are potentially useful in agriculture and medicine because (i) they have antiviral activity and (ii) they are used for the preparation of conjugates with antibodies ('immunotoxins') or other carriers, rendering them specifically toxic to the cell target of the carrier, which may be helpful in therapy. The distribution, mechanism of action and role in nature of RIPs are not completely understood, and we can expect several future developments in their practical application.

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Section: Antiviral and Other Antiparasitic Activitiesmentioning

confidence: 99%

mentioning

confidence: 99%

Ribosome-inactivating proteins: progress and problems

Stirpe

Battelli

2006

Cell. Mol. Life Sci.

321

225

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“…The study which shows that sugar beet ribosomes are resistant to beetin and probably also to other type 1 RIPs, is a case in point (Iglesias et al 2008). Besides, in some cases the antiviral activity of RIPs is independent on the eVect on ribosomes, as some RIPs can even depurinate other nucleic acids and polynucleotides including viral RNAs, thus inhibit the infection of virus (Parikh and Tumer 2004).…”

Section: Discussionmentioning

confidence: 97%

Stress-induced curcin-L promoter in leaves of Jatropha curcas L. and characterization in transgenic tobacco

Qin

Zheng

Shao

et al. 2009

Planta

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Ribosome-inactivating proteins (RIPs) represent a type of protein that universally inactivates the ribosome thus inhibiting protein biosynthesis. Curcin-L was a type I RIP found in Jatropha curcas L.. Its expression could be activated in leaves by treatments with abscisic acid, salicylic acid, polyethylene glycol, temperature 4, 45 degrees C and ultraviolet light. A 654 bp fragment of a 5' flanking region preceding the curcin-L gene, designated CP2, was cloned from the J. curcas genome and its expression pattern was studied via the expression of the beta-glucuronidase (GUS) gene in transgenic tobacco. Analysis of GUS activities showed that the CP2 was leaf specific, and was able to drive the expression of the reporter gene under stress-induction conditions. Analysis of a series of 5'-deletions of the CP2 suggested that several promoter motifs were necessary to respond to environmental stresses.

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“…In addition, it can be used in transgenic reagents in agriculture. Plants transfected with RIP genes exhibit broad-spectrum resistance to viral and fungal infection (Parikh and Tumer, 2004;Wang and Tumer, 2000) in the plant defense system.…”

Section: Introductionmentioning

confidence: 99%