Antiviral Activity of (+)-Rutamarin against Kaposi's Sarcoma-Associated Herpesvirus by Inhibition of the Catalytic Activity of Human Topoisomerase II

Xu, Baojun; González-Molleda, Lorenzo; Yan, Wang; Xu, Jing; Yuan, Yan

doi:10.1128/aac.01259-13

Cited by 33 publications

(21 citation statements)

References 44 publications

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“…The importance of the 4-HC pharmacophore for antiviral activity had been depicted in many studies. Therefore, Abd Elhafez et al reported a series of thiazolidinone (88), oxadiazoline (89) and hydrazone (90) containing coumarin derivatives as antiviral agents. Among all these, compound having p-chlorophenyl-thiazolidinone derivative had the highest activity and was able to reduce the number of plaques by 30% at a concentration of 0.12 mg/mL (MIC) having cytotoxicity CD 50 value 0.02 mg/mL [70].…”

Section: Hybrid Coumarin Analoguesmentioning

confidence: 99%

“…In this study, a total of 7200 compounds were virtually screened for their topoisomerase II inhibition properties and subsequently tested for antiviral activities. Out of these, natural product (þ) rutamarin, exhibited significant inhibition of both viral DNA synthesis and virion [88]. The sesquiterpene coumarin, kellerin (124) isolated from the gum resin of Ferula asafoetida significantly reduced the viral titre of the herpes virus type 1 (HSV-1) DNA viral strains KOS at concentrations of 10, 5 and 2.5 mg/mL with an inhibition rate of 98 ± 5.2%, 80% and 65%, respectively.…”

Section: Coumarin Analogues As Anti-herpes Simplex Agentsmentioning

confidence: 99%

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Therapeutic potential of coumarins as antiviral agents

Hassan

Osman

Ali

et al. 2016

European Journal of Medicinal Chemistry

313

126

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Coumarins have received a considerable attention in the last three decades as a lead structures for the discovery of orally bioavailable non-peptidic antiviral agents. A lot of structurally diverse coumarins analogues were found to display remarkable array of affinity with the different molecular targets for antiviral agents and slight modifications around the central motif result in pronounced changes in its antiviral spectrum. This manuscript thoroughly reviews the design, discovery and structure-activity relationship studies of the coumarin analogues as antiviral agents focusing mainly on lead optimization and its development into clinical candidates.

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Section: Hybrid Coumarin Analoguesmentioning

confidence: 99%

Section: Coumarin Analogues As Anti-herpes Simplex Agentsmentioning

confidence: 99%

Therapeutic potential of coumarins as antiviral agents

Hassan

Osman

Ali

et al. 2016

European Journal of Medicinal Chemistry

313

126

View full text Add to dashboard Cite

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“…The active compounds have structures similar to various classes of topoisomerase II inhibitors, and these results suggested that certain agents may serve as dual inhibitors of human DNA topoisomerase II as well as of KSHV DNA synthesis [ 100 , 117 ]. For example, (+)-Rutamarin, a topoisomerase II inhibitor isolated from plants, such as Ruta graveolens L, was also found to selectively inhibit KSHV replication [ 118 ].…”

Section: Inhibitors Of Kshv Lytic Replication Under Investigationmentioning

confidence: 99%

KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic Replication

Coen

Duraffour

Snoeck

et al. 2014

Viruses

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Kaposi’s sarcoma-associated herpesvirus (KSHV) is the causative agent of Kaposi’s sarcoma, primary effusion lymphoma and multicentric Castleman’s disease. Since the discovery of KSHV 20 years ago, there is still no standard treatment and the management of virus-associated malignancies remains toxic and incompletely efficacious. As the majority of tumor cells are latently infected with KSHV, currently marketed antivirals that target the virus lytic cycle have shown inconsistent results in clinic. Nevertheless, lytic replication plays a major role in disease progression and virus dissemination. Case reports and retrospective studies have pointed out the benefit of antiviral therapy in the treatment and prevention of KSHV-associated diseases. As a consequence, potent and selective antivirals are needed. This review focuses on the anti-KSHV activity, mode of action and current status of antiviral drugs targeting KSHV lytic cycle. Among these drugs, different subclasses of viral DNA polymerase inhibitors and compounds that do not target the viral DNA polymerase are being discussed. We also cover molecules that target cellular kinases, as well as the potential of new drug targets and animal models for antiviral testing.

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“…[12], antimicrobial [13], antinociceptive, anti-Alzheimer [14], anti-HIV [15], antiasthmatic [16] antiviral [17] antidepressant [18], antihyperlipidemic [19].…”

Section: Introductionmentioning

confidence: 99%

Biochemical Studies on Coumarin Derivatives as Antioxidant and Antitumor Agents

Mohammed

El-Deen

Tmamm

2019

AJRB

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Background: Coumarin derivatives have attracted intense interest in recent years, because they have anti-tumor, antioxidant activities, and induce apoptosis. Aims and Objective: Our study aims to evaluate the antitumor and anti-oxidant activities of new Coumarin derivatives: N-(P-chlorophenyl)-7-hydroxycoumarin-3-yl carboxamide and Ethyl 7-hydroxycoumarin-3-yl ester against in vivo tumor model. Methodology: the toxicity for the synthesized compounds was determined. The anticancer and anti-oxidant activities were studied by evaluation the viability of tumor cells, life span prolongation, and estimation of antioxidants. Results: Our compounds exhibited significant anti-oxidant activity towards Ehrlich ascites carcinoma (EAC) cells by reduction the MDA and NO concentration (p<0.001) compared to the positive control group. Whereas significantly increase in the G. peroxidase activity (p<0.001) in treated groups compared to the positive control group. Anticancer agent kills tumors by induction of apoptosis that showing significantly increases in Caspase-3 and Bax activity compared to positive control group. Discussion: The compound N-(P-chlorophenyl)-7-hydroxycoumarin-3-yl carboxamide is better than Ethyl 7-hydroxycoumarin-3-yl ester compound because of the nature of the halogen atom (a chlorine or a bromine atom) in the ‘meta’ position of the phenyl ring relative to the ester oxygen atom of 2-oxo-2H-1-benzopyran- 3-carboxylate led to a better anti-tumor effect than that observed in the absence of any substituent.

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Antiviral Activity of (+)-Rutamarin against Kaposi's Sarcoma-Associated Herpesvirus by Inhibition of the Catalytic Activity of Human Topoisomerase II

Cited by 33 publications

References 44 publications

Therapeutic potential of coumarins as antiviral agents

Therapeutic potential of coumarins as antiviral agents

KSHV Targeted Therapy: An Update on Inhibitors of Viral Lytic Replication

Biochemical Studies on Coumarin Derivatives as Antioxidant and Antitumor Agents

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