Antiviral Activity of Simalikalactone D, a Quassinoid from Quassia africana

Apers, Sandra; Cimanga, Kanyanga; Berghe, Dirk Vanden; Meenen, Els Van; Longanga, Albert Otshudi; Foriers, André; Vlietinck, A. J.; Pieters, Luc

doi:10.1055/s-2002-19870

Cited by 44 publications

(31 citation statements)

References 8 publications

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“…Melting point was 225-230°C. NMR spectra (Bruker AM-300 MHz spectrometer) were identical to those reported previously (Tresca et al, 1971;Moher et al, 1992;Apers et al, 2002).…”

Section: Extraction and Isolationmentioning

confidence: 53%

Larvicidal properties of simalikalactone d from Quassia africana (simaroubaceae) Baill and Baill, on the malaria vector Anopheles gambiae

Sama¹,

Ajaiyeoba²,

Choudhary³

2014

Afr. J. Trad. Compl. Alt. Med.

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Background: Botanical and microbial insecticides have been increasingly used for the control of mosquito given their efficacy and documented nontoxic effects on non-target organisms. The discovery of new insecticides is imperative because of the development of resistance by the mosquitoes to the readily available insecticides. The aim of this study was therefore to isolate and characterize compounds from a local medicinal plant, Quassia africana Baill and Baill (Simaroubaceae) that were toxic to Anopheles gambiae. Material and methods:The methanol extracts of the leaves, stem and roots of Quassia africana were tested against fourth instar larvae of An. gambiae. The root extract was partitioned into hexane, chloroform and ethyl acetate and the resulting extracts screened for larvicidal properties. The extracts and the fraction with the highest bioactivity were subjected to repeated column chromatography and isolated compounds evaluated for potential toxicity to An. gambiae larvae. The structure of the active compound was elucidated using spectroscopic techniques. The root extract showed the strongest activity profile (LC 50 = 17.58 μg/mL). The chloroform soluble fraction obtained after partitioning the crude extract into solvents based on polarities was the most toxic. Further bio-activity-guided chromatographic separation of the chloroform fraction of the root extract led to the identification and isolation of a simalikalactone D as the larvicidal compound in Q. africana (LC 50 = 1.25 μg/mL). Results: Results suggest that Q. africana may serve as a source for vector control agent for malaria. Conclusion: Simalikalactone D was identified as the larvicidal compound in Q. africana (LC 50 = 1.25 μg/mL).

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“…Melting point was 225-230°C. NMR spectra (Bruker AM-300 MHz spectrometer) were identical to those reported previously (Tresca et al, 1971;Moher et al, 1992;Apers et al, 2002).…”

Section: Extraction and Isolationmentioning

confidence: 53%

Larvicidal properties of simalikalactone d from Quassia africana (simaroubaceae) Baill and Baill, on the malaria vector Anopheles gambiae

Sama¹,

Ajaiyeoba²,

Choudhary³

2014

Afr. J. Trad. Compl. Alt. Med.

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“…In addition, various in vitro and in vivo studies have shown antiviral, insecticidal, anti-inflammatory, gastroprotective, antidiabetic, and antifertility activities of quassinoids [68][69][70][71][72][73].…”

Section: Propertiesmentioning

confidence: 99%

Revisiting Amazonian Plants for Skin Care and Disease

Burlando

Cornara

2017

Cosmetics

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Abstract:This review concerns five species of trees and palm trees that occur as dominant plants in different rainforest areas of the Amazon region. Due to their abundance, these species can be exploited as sustainable sources of botanical materials and include Carapa guianensis Aubl., family Meliaceae; Eperua falcata Aubl., family Fabaceae; Quassia amara L., family Simaroubaceae; and Attalea speciosa Mart. and Oenocarpus bataua Mart., family Arecaceae. For each species, the general features, major constituents, overall medicinal properties, detailed dermatological and skin care applications, and possible harmful effects have been considered. The major products include seed oils from A. speciosa and C. guianensis, fruit oil from O. bataua, and active compounds such as limonoids from C. guianensis, flavonoids from E. falcata, and quassinoids from Q. amara. The dermatologic and cosmetic applications of these plants are growing rapidly but are still widely based on empiric knowledge. Applications include skin rehydration and soothing; anti-inflammatory, antiage, and antiparasite effects; hair care; burn and wound healing; and the amelioration of rosacea and psoriasis conditions. Despite a limited knowledge about their constituents and properties, these species appear as promising sources of bioactive compounds for skin care and health applications. An improvement of knowledge about their properties will provide added value to the exploitation of these forest resources.

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“…13) Quassia africana extracts were tested for HSV-1, coxsackie B2, polio-1, measles, Semliki Forest virus and vesicular stomatitis virus, where simalikalactone D was found to be responsible for the antiviral effect. 14) Anagyrine, oxymatrine, sophoranol, wogonin and oroxylin found in Sophora flavescens and Scutellaria baicalensis were found to be responsible for inhibiting respiratory syncytial virus. 15) Herpesviruses are widespread, enveloped and doublestranded DNA agents which cause various infections in human and animals, especially in immunocompromised individuals.…”

mentioning

confidence: 99%

Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

Felipe

Rincão

Benati

et al. 2006

Biological & Pharmaceutical Bulletin

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Works on antiviral compounds date back to the 1950s, but for several reasons, only a couple of drugs were approved for clinical use about a decade later. To date, many antiviral drugs have been developed after extensive research and demanding trials, some of them with selective mechanisms against viral replication. 1) Although the primary focus has been on synthetic products, the number of natural compounds with antiviral action for different DNA and RNA viruses that are being studied is increasing. Many phytochemical compounds are being investigated based primarily on ethnopharmacologic knowledge and have been considered of great importance in new drug development. 2)Extracts of many plant species, such as Tridax procumbens, Carissa carandas, Mallotus philippensis, Streblus aspere, Terminatta alata, Macaranga pustulata, Sibbaldia micropetala, Hypericum cordifolium, H. uralum and Maesa macrophylla were found to be active against the replication of poliovirus and herpes simplex-1 (HSV-1), with some of them also active against Sindbis virus.3,4) A methanol extract of Annona muricata and aqueous extract of Petunia myctaginiflora were shown to inhibit HSV-1 cytopathic effect in Vero cells, at a concentration of 1 mg/ml. 5)Methanol extracts of Indonesian plants were tested for cytotoxicity and antiviral activity (HSV-1 and poliovirus) in murine and human cell lines. Piper aduncum was found to be active on poliovirus, while Elytranthe tubaeflora and Melastoma malabathricum inhibited HSV-1. 6) Dengue virus was inhibited by an aqueous extract of Azadirachta indica when assayed in mice. 7)Stem bark of Stryphnodendron adstringens (MART.) COV-ILLE, Leguminosae, popularly known in our country as barbatimão, has been empirically used as wound healing, astringent, antimicrobial, antifungal, antidiarrheal and hypoglycemic agents.8) Similarly, Guazuma ulmifolia LAM., Sterculiaceae, popularly known as mutamba, is known to have medicinal properties, such as wound healing, antiulcerogenic, hypoglycemic and antimicrobial. 9) G. ulmifolia aqueous and methanol fractions were found to inhibit HSV-1 replication, respectively, by 16.8% and 4.5%, at a concentration of 100 mg/ml, in a study of various plants. Those showing antiviral activity in vitro were also tested in HSV-1 infected mice. Melaleuca leucadendron and Nephelium lappaceum reduced mortality and delayed the appearance of lesions. 10)Among plant antiviral compounds, anthraquinones found in Aloe barbadensis inhibited HSV-1, HSV-2, varicela-zoster, pseudorabies and influenza.11) Stevia rebaudiana polysaccharides inhibited adsorption of human rotavirus in MA-104 cells.12) Flavonoids present in Troillius chinensis flowers also inhibited parainfluenza in HEp-2 cells.13) Quassia africana extracts were tested for HSV-1, coxsackie B2, polio-1, measles, Semliki Forest virus and vesicular stomatitis virus, where simalikalactone D was found to be responsible for the antiviral effect.14) Anagyrine, oxymatrine, sophoranol, wogonin and oroxylin found in Sophora flavescens and Scutellaria b...

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Antiviral Activity of Simalikalactone D, a Quassinoid from Quassia africana

Cited by 44 publications

References 8 publications

Larvicidal properties of simalikalactone d from <i>Quassia africana</i> (simaroubaceae) Baill and Baill, on the malaria vector <i>Anopheles gambiae</i>

Larvicidal properties of simalikalactone d from <i>Quassia africana</i> (simaroubaceae) Baill and Baill, on the malaria vector <i>Anopheles gambiae</i>

Revisiting Amazonian Plants for Skin Care and Disease

Antiviral Effect of Guazuma ulmifolia and Stryphnodendron adstringens on Poliovirus and Bovine Herpesvirus

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