Antiviral Activity of Trichothecene Mycotoxins (Deoxynivalenol, Fusarenon‐X, and Nivalenol) against Herpes Simplex Virus Types 1 and 2

Tani, Naoto; Dohi, Yoshiko; Onji, Yoshiki; Yonemasu, Kunio

doi:10.1111/j.1348-0421.1995.tb02254.x

Cited by 14 publications

(9 citation statements)

References 13 publications

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“…Although these trichothecenes have been associated to various biological properties, such as antibiotic, antimalarial and antileukemic activities and immunotoxic effects [1], [2], [3], [4], very few studies on their antiviral activity have been reported. Both simple (nivalenol, deoxynivalenol, fusarenon, T-2 toxin and related compounds) and macrocyclic (satratoxin G, roridin A and baccharinoids B-4 and B-5) trichothecenes were found to inhibit the replication of Herpes simplex virus [5], [6], [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Antiviral Activity Against Junin Virus of Macrocyclic Trichothecenes Produced by the Hypocrealean Epibiont of Baccharis coridifolia

et al. 2002

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Four macrocyclic trichothecenes, roridin A, roridin E, verrucarin A and verrucarin J, produced by the hypocrealean epibiont of Baccharis coridifolia, were evaluated for their inhibitory activity against the arenavirus Junin (JUNV), the etiological agent of Argentine hemorrhagic fever. The trichothecenes achieved a dose-dependent inhibition of JUNV multiplication at concentrations not affecting cell viability. The 50 % inhibitory concentration (IC50) values determined by a virus yield inhibition assay were in the range 1.2 - 4.9 ng/ml. The most active compound was verrucarin J which reduced JUNV yield more than 2 log units and had a similar effect against the arenavirus Tacaribe. The trichothecenes lacked virucidal effects on JUNV virions. From time of addition and removal experiments, it can be concluded that verrucarin J inhibited a late stage in the replicative cycle of JUNV, after 5 h of adsorption.

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Section: Introductionmentioning

confidence: 99%

Evaluation of the Antiviral Activity Against Junin Virus of Macrocyclic Trichothecenes Produced by the Hypocrealean Epibiont of Baccharis coridifolia

et al. 2002

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“…(Sudakin 2003), and from some higher plants such as Bacchairis artemisioides and Baccharis coridifolia (Habermehl et al 1985;Rizzo et al 1997), Ficus fistulosa and Rhaphidophora decursiva (Zhang et al 2002). Biologically, macrocyclic trichothecenes were reported to be antileukemic (Jarvis et al 1980(Jarvis et al , 1984, antimalarial (Isaka et al 1999;Zhang et al 2002), antimicrobial (Liu et al 2006;Wagenaar and Clardy 2001), antiviral (Tani et al 1995), phytotoxic and cytotoxic (Abbas et al 2002;Masuda et al 2007), and some were reported to possess animal toxicity (Hughes et al 1989). In the present study, the two trichothecenes (compounds 1 and 2), obtained from the EtOAc extract of the fungus JS9 isolated from the marine sponge Axinella sp., were ascertained to be antifungal compounds with the MICs comparable with those of fluconazole.…”

Section: Resultsmentioning

confidence: 95%

Potential inhibitors against Sclerotinia sclerotiorum, produced by the fungus Myrothecium sp. associated with the marine sponge Axinella sp.

et al. 2008

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Sclerotinia sclerotiorum is a worldwide ascomycete fungal plant pathogen, which causes enormous yield losses on major economic crops such as crucifers, grain legumes and several other plant families. The objective of this research was to isolate and characterise some bioactive products from cultures of fungi associated with the marine sponge Axinella sp. In total, nine fungal isolates were obtained from the marine sponge Axinella sp. collected from the South China Sea. A group of test strains, including two G + strains (Bacillus subtilis and Staphylococcus aureus), two G − strains (Escherichia coli and Pseudomonas aeruginosa) and three fungi including two plant pathogenic fungi Sclerotinia sclerotiorum and Magnaporthe grisea and Saccharomyces cerevisiae, were employed as the indicator organisms for bioactivity screening. Using antagonistic tests and bioactive screening of the ethyl acetate (EtOAc) extracts of the corresponding cultures, fungal isolate JS9 showed the stronger efficacy against the test indicator strains, especially the indicator fungal pathogens. Isolate JS9 was further identified as Myrothecium sp. by a combination of morphological features and 18S rDNA BLAST on GenBank. Two macrocyclic trichothecenes, roridin A (compound 1) and roridin D (compound 2) were purified by tracking the activity of the EtOAc extract fractions and characterised with spectral analyses including MS, 1 H-NMR, 13 C-NMR and disortionless enhancement by polarization transfer (DEPT). In vitro antifungal tests showed that the two macrocyclic trichothecenes were bioactive against S. cerevisiae, M. grisea and S. sclerotiorum with minimal inhibitory concentrations of 31.25, 125 and 31.25 μg ml −1 for roridin A, and 62.5, 250 and 31.25 μg ml −1 for roridin D, respectively. The present investigation demonstrated that two antifungal trichothecenes including roridin A and roridin D produced by the fungus Myrothecium sp. isolated from the marine sponge Axinella sp. could be potential inhibitors against the plant pathogen S. sclerotiorum.

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“…In our work, T2‐toxin ( 1 ) and the mixture of 8‐ n ‐butyryl‐ neo solaniol ( 2 ) and 8‐isobutyryl‐ neo solaniol ( 3 ) were shown for the first time to present activity against P. brasiliensis . Some trichothecene mycotoxins have several biological properties, such as antiviral (Herpes Simplex Virus type 2 and type 1), antibiotic, antimalarial, antileukaemic, and immunotoxic 43–49 …”

Section: Discussionmentioning

confidence: 99%

Antifungal activity of trichothecenes from Fusarium sp. against clinical isolates of Paracoccidioides brasiliensis

Campos¹,

Johann²,

Cota³

et al. 2010

Mycoses

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Paracoccidioidomycosis (PCM), a human mycosis caused by the dimorphic fungus Paracoccidioides brasiliensis, is a serious public health problem in several countries of Latin America. In our search we found that the crude extract of the endophytic fungus UFMGCB 551 was able to inhibit several clinical strains of P. brasiliensis, and was also active in the bioautographic assay against Cladosporium sphaerospermum. The endophytic fungus UFMGCB 551 was isolated from the plant Piptadenia adiantoides J.F. Macbr (Fabaceae). The fungus was identified as Fusarium sp. based on its macro- and micro-morphology, and on the sequence of the internally transcribed spacer regions (ITS) of its rRNA gene. The chromatographic fractionation of the fungal extract was guided by the bioautographic assay to afford three known trichothecene mycotoxins: T2-toxin (1) and a mixture of 8-n-butyrylneosolaniol (2) and 8-isobutyrylsolaniol (3). The minimal inhibitory concentrations (MIC) of the these compounds against eleven clinical strains of P. brasiliensis were evaluated and found to be in the range between 75 and 640 nmol l(-1) for 1 and 160-640 nmol l(-1) for the mixture of 2 and 3.

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Antiviral Activity of Trichothecene Mycotoxins (Deoxynivalenol, Fusarenon‐X, and Nivalenol) against Herpes Simplex Virus Types 1 and 2

Cited by 14 publications

References 13 publications

Evaluation of the Antiviral Activity Against Junin Virus of Macrocyclic Trichothecenes Produced by the Hypocrealean Epibiont of Baccharis coridifolia

Evaluation of the Antiviral Activity Against Junin Virus of Macrocyclic Trichothecenes Produced by the Hypocrealean Epibiont of Baccharis coridifolia

Potential inhibitors against Sclerotinia sclerotiorum, produced by the fungus Myrothecium sp. associated with the marine sponge Axinella sp.

Antifungal activity of trichothecenes from Fusarium sp. against clinical isolates of Paracoccidioides brasiliensis

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