Antiviral agents from natural sources

Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2

“…For this reason, many investigators have attempted to search for new, effective and inexpensive antiviral drugs from natural sources. It has been reported that some compounds derived from plants and animals have in vitro and in vivo activity against selected sexually transmitted pathogens [11][12][13]. Several sulphated polysaccharides, such as heparin, dextran sulphate, pentosan polysulphate, mannan sulphate, sulphated cyclodextrins, carrageenans, xylofuranan sulphate, and ribofuranan sulphate have been shown to inhibit the replication of various enveloped viruses, including HSV, human cytomegalovirus (HCMV), and HIV [14][15][16][17][18][19].…”

Multi-Step In Silico Discovery of Natural Drugs against COVID-19 Targeting Main Protease

“…The bacterium Amycolatopsis rifamycinica [100] Inhibited (in vitro) murine sarcoma virus through cell transformation inhibition [101]…”

Animal viruses of economic importance: Genetic variation, persistence, and prospects for their control

“…Many other chemicals, synthetic and natural have been tested as antivirals in cell culture models and in some cases in animal models, but there seems to have been little systematic attempt to apply any of these to domestic animals or to fish. More details on the naturally-occurring chemicals can be found in the review by Becker (1980). Thus, the prospects for chemotherapy of a few specific virus infections, notably herpes infections, are good in view of our ability to design chemicals for the specific task of interfering with viral enzymes.…”