Antiviral amantadine

Nisar, Taha; Sutherland-Foggio, Harry; Husar, Walter

doi:10.1016/s1474-4422(19)30361-8

Cited by 19 publications

(11 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surprising fact is that both substances have known antiviral effect, Memantine showing efficacy for viral infections with neurotropism, such as human coronavirus (HCoV), HIV, HSV, while Amantadine is even indication approved by Food and Drug Administration (FDA) for the prophylaxis and treatment of the infection with influenza A virus (IAV) [9,10]. On the other hand, the infections with HIV, HSV and IAV were correlate with PD pathogenesis or parkinsonism [11], while HIV and HSV were involved in AD pathogenesis [12].…”

Section:  Memantine and Amantadine Psychotropic Medication With Antiviral Actionmentioning

confidence: 99%

SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine

Marinescu¹,

Marinescu²,

Mogoantă³

et al. 2021

Rom J Morphol Embryol

View full text Add to dashboard Cite

This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited. REVIEW SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and AmantadineILEANA MARINESCU 1) , DRAGOŞ MARINESCU 2) , LAURENŢIU MOGOANTĂ 3) , ION CRISTIAN EFREM 4) , PUIU OLIVIAN STOVICEK 5)

show abstract

Section:  Memantine and Amantadine Psychotropic Medication With Antiviral Actionmentioning

confidence: 99%

SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine

Marinescu¹,

Marinescu²,

Mogoantă³

et al. 2021

Rom J Morphol Embryol

View full text Add to dashboard Cite

show abstract

“…Specifically, Amantadine HCl is an organic compound that was developed to address influenza infections. [ 9 ] It has been repurposed for treatment of motor impairment in Parkinson's disease, [ 10 ] and explored for improvement of fatigue in patients with multiple sclerosis. [ 11 ] Dexamethasone is a potent anti‐inflammatory and immunosuppressant glucocorticoid.…”

Section: Introductionmentioning

confidence: 99%

Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention

Abdulla

Wang

Feng

et al. 2020

Advanced Therapeutics

View full text Add to dashboard Cite

In 2019/2020, the emergence of coronavirus disease 2019 (COVID-19) resulted in rapid increases in infection rates as well as patient mortality. Treatment options addressing COVID-19 included drug repurposing, investigational therapies such as remdesivir, and vaccine development. Combination therapy based on drug repurposing is among the most widely pursued of these efforts. Multi-drug regimens are traditionally designed by selecting drugs based on their mechanism of action. This is followed by dose-finding to achieve drug synergy. This approach is widely-used for drug development and repurposing. Realizing synergistic combinations, however, is a substantially different outcome compared to globally optimizing combination therapy, which realizes the best possible treatment outcome by a set of candidate therapies and doses toward a disease indication. To address this challenge, the results of Project IDentif.AI (Identifying Infectious Disease Combination Therapy with Artificial Intelligence) are reported. An AI-based platform is used to interrogate a massive 12 drug/dose parameter space, rapidly identifying actionable combination therapies that optimally inhibit A549 lung cell infection by vesicular stomatitis virus within three days of project start. Importantly, a sevenfold difference in efficacy is observed between the top-ranked combination being optimally and sub-optimally dosed, demonstrating the critical importance of ideal drug and dose identification. This platform is disease indication and disease mechanism-agnostic, and potentially applicable to the systematic N-of-1 and population-wide design of highly efficacious and tolerable clinical regimens. This work also discusses key factors ranging from healthcare economics to global health policy that may serve to drive the broader deployment of this platform to address COVID-19 and future pandemics.

show abstract

“…Many blockbuster drugs are the result of a repurposing process, with serendipity being a frequent part of such discoveries, especially in the past century. Amantadine was first approved in the 1960s for flu prophylaxis [ 76 ] but is now no longer recommended as an antiviral agent. Indeed, amantadine is now mostly known as an antiparkinsonian agent.…”

Section: Artificial Intelligence and Network Medicine For A Therapy T...mentioning

confidence: 99%

Looking at COVID-19 from a Systems Biology Perspective

2022

View full text Add to dashboard Cite

The sudden outbreak and worldwide spread of the SARS-CoV-2 pandemic pushed the scientific community to find fast solutions to cope with the health emergency. COVID-19 complexity, in terms of clinical outcomes, severity, and response to therapy suggested the use of multifactorial strategies, characteristic of the network medicine, to approach the study of the pathobiology. Proteomics and interactomics especially allow to generate datasets that, reduced and represented in the forms of networks, can be analyzed with the tools of systems biology to unveil specific pathways central to virus–human host interaction. Moreover, artificial intelligence tools can be implemented for the identification of druggable targets and drug repurposing. In this review article, we provide an overview of the results obtained so far, from a systems biology perspective, in the understanding of COVID-19 pathobiology and virus–host interactions, and in the development of disease classifiers and tools for drug repurposing.

show abstract

Antiviral amantadine

Cited by 19 publications

References 4 publications

SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine

SARS-CoV-2 infection in patients with serious mental illness and possible benefits of prophylaxis with Memantine and Amantadine

Project IDentif.AI: Harnessing Artificial Intelligence to Rapidly Optimize Combination Therapy Development for Infectious Disease Intervention

Looking at COVID-19 from a Systems Biology Perspective

Contact Info

Product

Resources

About