Antiviral and Immunostimulant Activities of Andrographis paniculata

Churiyah,; Pongtuluran, Olivia Bunga; Rofaani, Elrade; Tarwadi,

doi:10.4308/hjb.22.2.67

Cited by 70 publications

(41 citation statements)

References 12 publications

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“…This indicates that a high-fat diet with or without administration of A. paniculata does not stimulate Th17 cells to produce IL-17. This extends the result of previous study that revealed A. paniculata at low doses may stimulate lymphocyte cell proliferation [11].…”

Section: Discussionsupporting

confidence: 91%

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Andrographis paniculata can modulate the ratio of Treg to Th17 cells in atherosclerotic rats

Hendrata

Handono

Kalim

et al. 2018

Clinical Nutrition Experimental

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s u m m a r yThe purpose of this study is to analyze the effect of Andrographis paniculata (Burm F) in the modulation of naive T cell differentiation and its related cytokines in the rat model of atherosclerosis. Twenty-five male rats were assigned to five study groups, consisting of the control group (normal diet), the atherosclerosis rat group (atherogenic diet), and the atherosclerotic rat group receiving A. paniculata (Burm F) extracts in three doses, there were 0.6 mg/kgBBW (Ather þ AP1 group), 1.2 mg/kgBBW (Ather þ AP2 group) and 2.4 mg/kgBBW (Ather þ AP3 group). The numbers of Th17 and Treg cells were measured using flow cytometry. The IL-17 and IL-6 levels were analyzed using enzyme-linked immunosorbent assay technique. Th17 cell level increased significantly in the atherosclerosis group compared to the control group (p > 0.05). The A. paniculata extract in the 0.6 mg/kgBBW and 2.4 mg/kgBBW doses could decrease the Th17 cell count significantly compared to the atherosclerosis group (p < 0.05), despite did not achieve a normal value similar to the control group (p < 0.05). The A. paniculata extract in the 1.2 mg/kgBBW dose significantly increased Treg cell count compared to the other groups (p < 0.05). The ratio of Treg cells to Th17 cells dropped significantly in the atherosclerosis group to the control group (p > 0.05). A. paniculata extract of

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Section: Discussionsupporting

confidence: 91%

“…This indicates that the A. paniculata can modulate the immune system associated with T cell differentiation in atherosclerosis. This study extends the earlier findings, stating that A. paniculata is able to regulate Th1/Th2/Th17 homeostasis [11]. This plant extract contains andrographolide of 43.25%.…”

Section: Discussionsupporting

confidence: 90%

Andrographis paniculata can modulate the ratio of Treg to Th17 cells in atherosclerotic rats

Hendrata

Handono

Kalim

et al. 2018

Clinical Nutrition Experimental

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“…The Andrographolide contained in ApN exhibits immunostimulatory, antiviral, and antibacterial pharmacological properties. 9,10 The purpose of this research was to prove the potency of ApN extract to increase monocytes viability after exposure to P. gingivalis.…”

Section: Ap25mentioning

confidence: 99%

The potency of Andrographis paniculata Nees extract to increase the viability of monocytes following exposure to Porphyromonas gingivalis

Rahayu¹,

Indahyani²,

Pradipta³

et al. 2019

Dent. J.

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Background: Periodontitis is a chronic infectious disease affecting the global population. In Indonesia, the prevalence of periodontal disease has reached 57.6% across all age groups. The bacterium considered as the orginator factor of periodontitis is Porphyromonas gingivalis (P. gingivalis). Herbal ingredients are currently being promoted as a form of treatment because of the minimal side effects they induce. Andrographis paniculata Nees (ApN) extract produces pharmacological effects, including ones immunomodulatory in character, rendering possible its application as a preparation for treating periodontitis. Purpose: The purpose of the study was to prove the potency of Andrographis paniculata Nees extract in increasing the viability of monocytes following exposure to P. gingivalis. Methods: The sample was divided into four groups, namely; Control negative (C-): monocytes in the medium, not exposed to P. gingivalis; Control positive (C+): monocytes in the medium, exposed to P. gingivalis; Treatment I (AP25): monocytes with 25% ApN extract, exposed to P. gingivalis; Treatment II (AP50): monocytes with 50% ApN extract, exposed with P. gingivalis. The monocytes were exposed to 100 uL P. gingivalis for 4.5 hours and stained with trypan blue. Observations were conducted using an inverted microscope at 200x magnification. The percentage of viable monocytes was calculated based on the ratio of the number of the cells which absorbed trypan blue staining to that which did not. Data was tested using a one-way ANOVA followed by an LSD test. Results: There were significant differences between the treatment groups in the number of viable monocytes (p=0.001) they contained. Monocyte viability was higher in the 25% ApN extract group than that exposed to 50% P. gingivalis. Conclusion: Andrographis paniculata Nees extract demonstrates the potency to increase monocyte viability following exposure to P. gingivalis.

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“…The concentration and composition of chemical constituents in plants are greatly affected by variable factors like harvesting condition, growth condition, genetic factors, types of extraction solvent, and concentration of solvents [31]. Churiyah [32] indicated that the ethanol fraction of A. paniculata inhibited the titre of SRC virus in a similar way as done by Lamivudine control in A549 cell line. Wintachai [33] reported that andrographolide of A. paniculata can be employed as a curative agent against CHIKV (Chikungunya virus.…”

Section: Introductionmentioning

confidence: 99%

Canthin-6-One 9-O-Beta-Glucopyranoside: an inhibitor of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/ 3CLpro

Verma¹,

Mitra²,

Kamboj³

et al. 2020

Preprint

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The rapid spread of SARS-CoV-2 has raised a severe global public health issue, where therapy is not identified with specific drugs or vaccines. The present investigation dealt with the inhibition of various proteins and receptors of virus using phytocompounds of three pertinent medicinal plants i.e. Eurycoma harmandiana, Sophora flavescens and Andrographis paniculata. Phytocompounds known to have antiviral properties were screened against the papain-like protease (PLpro) and main protease (Mpro) / 3-chymotrypsin-like Protease (3CLpro). Molecular docking with Canthin-6-One 9-O-Beta-Glucopyranoside showed the highest binding affinity and least binding energy with both the proteases viz. PLpro and Mpro/ 3CLpro. ADMET analysis of the compound suggested that it is having drug-like properties like high gastrointestinal (gi-) absorption, no blood-brain barrier permeability, and high lipophilicity.

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Antiviral and Immunostimulant Activities of Andrographis paniculata

Cited by 70 publications

References 12 publications

Andrographis paniculata can modulate the ratio of Treg to Th17 cells in atherosclerotic rats

Andrographis paniculata can modulate the ratio of Treg to Th17 cells in atherosclerotic rats

The potency of Andrographis paniculata Nees extract to increase the viability of monocytes following exposure to Porphyromonas gingivalis

Canthin-6-One 9-O-Beta-Glucopyranoside: an inhibitor of SARS-CoV-2 (COVID 19) proteases PLpro and Mpro/ 3CLpro

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