Antiviral Drugs

Vardanyan, Ruben; Hruby, Victor J.

doi:10.1016/b978-044452166-8/50036-4

Cited by 71 publications

(47 citation statements)

References 22 publications

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“…To prove the potential of the protocol in late-stage functionalizations, the authors synthesized the deoxyuridine derivative 163 (Scheme 51D). Deoxyuridine is similar to drugs like idoxuridine and trifluridine, which have been used as antiviral drugs [235].…”

Section: Wu and Co-workers Reported A Cobalt-catalyzed C-h Carbonylation Of Naphthylamides To Afford A Series Of Free Nh-benzo[cd]indol-2mentioning

confidence: 99%

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

Carvalho¹,

Miranda²,

Nunes³

et al. 2021

Beilstein J. Org. Chem.

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Several valuable biologically active molecules can be obtained through C–H activation processes. However, the use of expensive and not readily accessible catalysts complicates the process of pharmacological application of these compounds. A plausible way to overcome this issue is developing and using cheaper, more accessible, and equally effective catalysts. First-row transition (3d) metals have shown to be important catalysts in this matter. This review summarizes the use of 3d metal catalysts in C–H activation processes to obtain potentially (or proved) biologically active compounds.

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Section: Wu and Co-workers Reported A Cobalt-catalyzed C-h Carbonylation Of Naphthylamides To Afford A Series Of Free Nh-benzo[cd]indol-2mentioning

confidence: 99%

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

Carvalho¹,

Miranda²,

Nunes³

et al. 2021

Beilstein J. Org. Chem.

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“…Acyl hydrazides are a very important class of organic compounds [1–2] with a wide spectrum of biological activities, including antituberculous, [3–6] anticonvulsant, [7] antidepressant, [8] anti‐inflammatory, [9] antimalarial, [10] anticancer, [12] antimycobacterial, [11] antituberculous, [13] etc. Acyl hydrazide derivatives are clinically used as antituberculous (isoniazid), antidepressant (iproniazid and marplan), antibacterial drugs (Figure 1), etc [14–18] . Moreover, acyl hydrazides found different applications in the field of herbicides, polymers, chemical preservers, etc [19] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Acyl Hydrazides from Carboxamides and Hydrazine Hydrate Under Metal‐Free Conditions at Room Temperature

Singh

Kandasamy

2023

Asian J Org Chem

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Synthesis of acyl hydrazides from amides has been achieved at room temperature through N‐activation reactions. A wide spectrum of functionalized primary and secondary amides was initially converted into N‐Boc, N‐nitroso and N‐tosyl amides and subjected to transamidation with hydrazine hydrate to obtain the desired acyl hydrazides in 76–94% yields. Broad substrate scope, shorter reaction time and mild reaction conditions are the merits of the developed methodology.

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“…In addition, these compounds are the important intermediates in the synthesis of some of the drugs such as Amantadine (antiviral and antiparkinsonian). [36] A range of methods is reported for the amide bond formation. Among various procedures, the Ritter reaction is one of the famous synthetic methods for the preparation of different amides from alcohols and nitriles.…”

Section: Introductionmentioning

confidence: 99%

Acidic Ionic Liquid Bridge Supported on Nano Rice Husk Ash: An Efficient Promoter for the Conversion of Nitriles to Their Corresponding 5‐Substituted 1H‐Tetrazoles and Amides

Mazloumi

Shirini

2023

ChemistrySelect

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In this study, an efficient method is reported for the preparation of 5‐substituted 1H‐tetrazoles and amides using nano rice husk ash modified with an ionic liquid bridge [RHA‐[bip]‐NH2+ HSO4−] as a new heterogeneous catalyst. This reagent was obtained easily and simply from the preparation and consolidation of bis‐3‐(trimethoxysilylpropyl)‐ammonium hydrogen sulfate on nano rice husk ash and identified with different methods including FT‐IR, XRD, FESEM, TEM and TGA. All products using this catalyst were obtained in suitable times with excellent isolated yields without the formation of any by‐products. Heterogeneous nature of the reaction conditions, ease of the preparation of the catalyst and its stability and reusability are the other important features of this method.

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Antiviral Drugs

Cited by 71 publications

References 22 publications

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

On the application of 3d metals for C–H activation toward bioactive compounds: The key step for the synthesis of silver bullets

Synthesis of Acyl Hydrazides from Carboxamides and Hydrazine Hydrate Under Metal‐Free Conditions at Room Temperature

Acidic Ionic Liquid Bridge Supported on Nano Rice Husk Ash: An Efficient Promoter for the Conversion of Nitriles to Their Corresponding 5‐Substituted 1H‐Tetrazoles and Amides

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