Antiviral effect of Curcuma longa Linn extract against hepatitis B virus replication

Kim, Hye Jin; Yoo, Hwa Seung; Kim, Jin Chul; Park, Chan Su; Choi, Mi Sun; Kim, Mi-Jee; Choi, Hyangsoon; Min, Jung Sun; Kim, Yong Soo; Yoon, Seong Woo; Ahn, Jeong Keun

doi:10.1016/j.jep.2009.04.046

Cited by 126 publications

(71 citation statements)

References 36 publications

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“…It inhibits extracellular matrix formation by enhancing HSC matrix metalloproteinase expression via PPARγ and suppresses connective tissue growth factor expression [98] . CLL extract also represses HBV replication by enhancing the level of p53 protein [99] .…”

Section: Curcuminoidsmentioning

confidence: 99%

Oxidative stress and antioxidants in hepatic pathogenesis

Shin²,

Feitelson³

et al. 2010

WJG

205

137

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Long term hepatitis B virus (HBV) infection is a major risk factor in pathogenesis of chronic liver diseases, including hepatocellular carcinoma (HCC). The HBV encoded proteins, hepatitis B virus X protein and preS, appear to contribute importantly to the pathogenesis of HCC. Both are associated with oxidative stress, which can damage cellular molecules like lipids, proteins, and DNA during chronic infection. Chronic alcohol use is another important factor that contributes to oxidative stress in the liver. Previous studies reported that treatment with antioxidants, such as curcumin, silymarin, green tea, and vitamins C and E, can protect DNA from damage and regulate liver pathogenesis-related cascades by reducing reactive oxygen species. This review summarizes some of the relationships between oxidative stress and liver pathogenesis, focusing upon HBV and alcohol, and suggests antioxidant therapeutic approaches.

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Section: Curcuminoidsmentioning

confidence: 99%

Oxidative stress and antioxidants in hepatic pathogenesis

Shin²,

Feitelson³

et al. 2010

WJG

205

137

View full text Add to dashboard Cite

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“…The Curcuma longa extract suppressed HBV replication by increasing the rate of p53 protein through enhancing the stability of the protein as well as transactivating the transcription of p53 gene. It was understood that the extract has suppressed HBV enhancer I and X promoter leading to repression of HBx gene transcription by affecting p53 [35]. In vitro investigation of the antiviral activity of curcumin Huh7 replicon cells expressing the hepatitis C virus (HCV) indicated that curcumin can be a potent anti-HCV compound.…”

Section: Antiviral Activitymentioning

confidence: 99%

A Review on Antibacterial, Antiviral, and Antifungal Activity of Curcumin

Moghadamtousi

Kadir

Hassandarvish

et al. 2014

BioMed Research International

894

608

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Curcuma longa L. (Zingiberaceae family) and its polyphenolic compound curcumin have been subjected to a variety of antimicrobial investigations due to extensive traditional uses and low side effects. Antimicrobial activities for curcumin and rhizome extract of C. longa against different bacteria, viruses, fungi, and parasites have been reported. The promising results for antimicrobial activity of curcumin made it a good candidate to enhance the inhibitory effect of existing antimicrobial agents through synergism. Indeed, different investigations have been done to increase the antimicrobial activity of curcumin, including synthesis of different chemical derivatives to increase its water solubility as well ass cell up take of curcumin. This review aims to summarize previous antimicrobial studies of curcumin towards its application in the future studies as a natural antimicrobial agent.

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“…[29] (7) The leaves of T. sinensis were collected being powdered, then dissolved in a mobile phase consisting of methanol:water (50:50, v/v) before high performance liquid chromatography (HPLC) analysis. Chromatographic discrimination was obtained by isocratic elution with methanol:water (50:50, v/v) during the first 15 min followed by gradually increasing the methanol proportion to 100% over a period of 10 min.…”

Section: Bioactive Compounds From Natural Sources Isolationmentioning

confidence: 99%