Antiviral effects of dehydroascorbic acid

Uozaki, Misao; Ikeda, Keiko; Tsujimoto, Kazuko; Nishide, Mitsunori; Yamasaki, Hisashi; Khamsri, Boonruang; Koyama, A. Hajime

doi:10.3892/etm.2010.139

Cited by 13 publications

(8 citation statements)

References 12 publications

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“…VitC is extensively used to attenuate the symptoms of common cold [ 186 – 190 ]. In correlation, it has been reported that DHA, the oxidized form of VitC, inhibits the multiplication of viruses of three different families: herpes simplex virus type 1 (HSV-1), influenza virus type A, and poliovirus type 1, perhaps at the step of nucleocapsid formation occurring inside the Golgi cisternae of infected cells [ 191 ]. It has been proposed that VitC may contribute to maintain a healthy skin by altering the gene expression profile of dermal fibroblasts [ 192 ].…”

Section: Biotechnological and Medical Applicationsmentioning

confidence: 99%

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

D’Aniello

Cermola

Patriarca

et al. 2017

Stem Cells International

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Transcription factors and signaling molecules are well-known regulators of stem cell identity and behavior; however, increasing evidence indicates that environmental cues contribute to this complex network of stimuli, acting as crucial determinants of stem cell fate. l-Ascorbic acid (vitamin C (VitC)) has gained growing interest for its multiple functions and mechanisms of action, contributing to the homeostasis of normal tissues and organs as well as to tissue regeneration. Here, we review the main functions of VitC and its effects on stem cells, focusing on its activity as cofactor of Fe+2/αKG dioxygenases, which regulate the epigenetic signatures, the redox status, and the extracellular matrix (ECM) composition, depending on the enzymes' subcellular localization. Acting as cofactor of collagen prolyl hydroxylases in the endoplasmic reticulum, VitC regulates ECM/collagen homeostasis and plays a key role in the differentiation of mesenchymal stem cells towards osteoblasts, chondrocytes, and tendons. In the nucleus, VitC enhances the activity of DNA and histone demethylases, improving somatic cell reprogramming and pushing embryonic stem cell towards the naive pluripotent state. The broad spectrum of actions of VitC highlights its relevance for stem cell biology in both physiology and disease.

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Section: Biotechnological and Medical Applicationsmentioning

confidence: 99%

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

D’Aniello

Cermola

Patriarca

et al. 2017

Stem Cells International

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“…Nakajima, Nagoya City University, Nagoya, Japan), HEp-2 cells (obtained from Dr Takahiro Uchida, Tokushima University, Tokushima, Japan) and Vero cells (obtained from Dr Kamesaburo Yoshino, University of Tokyo, Tokyo, Japan) were grown in Eagle's minimum essential medium (MEM) , A. HAJIME KOYAMA 3,6 and HISASHI YAMASAKI (Nissui Pharmaceutical Co., Ltd., Tokyo, Japan) containing 5% fetal bovine serum (FBS) (Euroclone, Pero, Italy). Influenza virus A/Aichi/68 (H3N2) (obtained from Dr Katsuhisa Nakajima, Nagoya City University), Sabin strain of poliovirus type 1 (PV-1) (from Dr Akio Nomoto, University of Tokyo) and HSV-1 strain F (from Dr Bernard Roizman, Chicago University, Chicago, IL, USA), were used throughout the experiments.…”

Section: Cells and Viruses The Mdck Cells (Obtained From Dr Katsuhisamentioning

confidence: 99%

Inhibition by caffeic acid of the influenza A virus multiplication in vitro

Utsunomiya

Ichinose

Ikeda

et al. 2014

International Journal of Molecular Medicine

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Abstract. Caffeic acid has been shown to inhibit the multiplication of influenza A virus in vitro, whereas caffeine, quinic acid and chlorogenic acid do not. Caffeic acid has also been shown to have antiviral activity against herpes simplex virus (DNA virus) and polio virus (RNA virus). In the present study, a comparison of the one-step growth curve of the influenza virus in the presence of caffeic acid with that in the absence of the reagent showed that an eclipse period of the virus multiplication in the infected cells was not affected by the reagent, while the progeny virus yield was markedly decreased in the presence of caffeic acid. In additional experiments, it was found that the addition of caffeic acid at an early time point post-infection (within 3 h post-infection) was mandatory for extensive antiviral activity, suggesting that a major target of the reagent exists in the early stages of infection. Simultaneously with the decrease in the progeny virus yield, both the virusinduced cytopathic effects and apoptotic nuclear fragmentation were markedly suppressed by the reagent, suggesting that caffeic acid suppresses, at least temporally, the degeneration of the virus-infected cells and that the observed antiviral activity is likely not the secondary result of the cytotoxic effects of the reagent. These results suggest the potential pharmacological use of caffeic acid or its derivatives as an antiviral drug against influenza A virus.

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“…Resveratrol (Figure 20) could interrupt the translocation process of RNPs from the nucleus to the cytoplasm and may be useful as an anti-influenza drug (295)(296)(297). Ascorbic and dehydroascorbic acids (Figure 20) also possess the antiviral effect, and this effect may work at the envelopment of viral nucleocapsids after the completion of viral DNA replication (298,299).…”

Section: Other Targets and Strategiesmentioning

confidence: 99%

Progress of small molecular inhibitors in the development of anti-influenza virus agents

Wu¹,

Wu²,

Sun³

et al. 2017

Theranostics

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The influenza pandemic is a major threat to human health, and highly aggressive strains such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to combat these pathogens. Influenza anti-viral agents, especially active small molecular inhibitors play important roles in controlling pandemics while vaccines are developed. Currently, only a few drugs, which function as influenza neuraminidase (NA) inhibitors and M2 ion channel protein inhibitors, are approved in clinical. However, the acquired resistance against current anti-influenza drugs and the emerging mutations of influenza virus itself remain the major challenging unmet medical needs for influenza treatment. It is highly desirable to identify novel anti-influenza agents. This paper reviews the progress of small molecular inhibitors act as antiviral agents, which include hemagglutinin (HA) inhibitors, RNA-dependent RNA polymerase (RdRp) inhibitors, NA inhibitors and M2 ion channel protein inhibitors etc. Moreover, we also summarize new, recently reported potential targets and discuss strategies for the development of new anti-influenza virus drugs.

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Antiviral effects of dehydroascorbic acid

Cited by 13 publications

References 12 publications

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics

Inhibition by caffeic acid of the influenza A virus multiplication in vitro

Progress of small molecular inhibitors in the development of anti-influenza virus agents

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